Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables catechol O-methyltransferase activity. Acts upstream of or within several processes, including catecholamine metabolic process; learning or memory; and signal release. Located in mitochondrion. Is active in cytosol and vesicle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and sensory organ. Used to study cognitive disorder and pre-eclampsia. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease of skin and connective tissue (multiple); cognitive disorder (multiple); drug dependence (multiple); reproductive organ cancer (multiple); and withdrawal disorder (multiple). Orthologous to human COMT (catechol-O-methyltransferase).