Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Comt. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Comt
  • participates in the following biological processes:
    • dopamine catabolic process ^[1]
  • performs the following molecular functions:
    • catechol O-methyltransferase activity ^[3]
  • is located in the following cellular components:
    • mitochondrion ^[4]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Comt
  • participates in the following biological processes:
    • catechol-containing compound metabolic process ^[2]
    • dopamine metabolic process ^[2]
  • performs the following molecular functions:
    • catechol O-methyltransferase activity ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Comt:
  • participates in the following biological processes:
    • estrogen metabolic process
    • female pregnancy
    • learning
    • multicellular organismal reproductive process
    • negative regulation of dopamine metabolic process
    • negative regulation of smooth muscle cell proliferation
    • positive regulation of homocysteine metabolic process
    • response to pain
  • performs the following molecular functions:
    • catechol O-methyltransferase activity
  • is located in the following cellular components:
    • intracellular membrane-bounded organelle
    • membrane

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Summary text based on GO annotations supported by structural data

• Comt encodes a protein or proteins that contain the following InterPro domains: Catechol O-methyltransferase, Catechol O-methyltransferase, eukaryotic, O-methyltransferase, family 3, indicating that the gene product:
  • participates in the following biological processes:
    • catecholamine metabolic process
    • neurotransmitter catabolic process
  • performs the following molecular functions:
    • magnesium ion binding
    • O-methyltransferase activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Comt indicates that it:
  • participates in the following biological processes:
    • catecholamine metabolic process
    • metabolic process
    • methylation
    • neurotransmitter catabolic process
  • performs the following molecular functions:
    • metal ion binding
    • methyltransferase activity
    • transferase activity
  • is located in the following cellular components:
    • cytoplasm
    • integral to membrane

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References

1. Jones SR et al. (1998) Profound neuronal plasticity in response to inactivation of the dopamine transporter. Proc Natl Acad Sci U S A, 95:4029-34. (PubMed:9520487)
2. Kaenmaki M et al. (2009) Importance of membrane-bound catechol-O-methyltransferase in L-DOPA metabolism: a pharmacokinetic study in two types of Comt gene modified mice. Br J Pharmacol, 158:1884-94. (PubMed:19930170)
3. Myohanen TT et al. (2010) Distribution of catechol-O-methyltransferase (COMT) proteins and enzymatic activities in wild-type and soluble COMT deficient mice. J Neurochem, 113:1632-43. (PubMed:20374420)
4. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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