Automated description from the Alliance of Genome Resources (Release 4.0)
Enables identical protein binding activity. An extracellular matrix structural constituent. Acts upstream of or within several processes, including cellular response to mechanical stimulus; face morphogenesis; and skeletal system morphogenesis. Located in cytoplasm and extracellular matrix. Part of collagen type I trimer. Is expressed in several structures, including alimentary system; embryo mesenchyme; eye; heart and pericardium; and skeleton. Used to study Ehlers-Danlos syndrome and osteogenesis imperfecta (multiple). Human ortholog(s) of this gene implicated in several diseases, including Ehlers-Danlos syndrome arthrochalasia type 1; aggressive periodontitis; bone disease (multiple); cutaneous leishmaniasis; and dentinogenesis imperfecta. Orthologous to human COL1A1 (collagen type I alpha 1 chain).