Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Col4a1. (This text reflects annotations as of Thursday, July 24, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the major type IV alpha collagen chain of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Col4a1
  • participates in the following biological processes:
    • cellular response to amino acid stimulus ^[7]
  • is located in the following cellular components:
    • basement membrane ^{[2, 3, 4, 5, 6]}
    • collagen type IV trimer ^[8]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Col4a1
  • participates in the following biological processes:
    • neuromuscular junction development ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Col4a1:
  • participates in the following biological processes:
    • basement membrane organization
    • blood vessel morphogenesis
    • brain development
    • patterning of blood vessels
    • renal tubule morphogenesis
    • retinal blood vessel morphogenesis
  • performs the following molecular functions:
    • extracellular matrix structural constituent
    • platelet-derived growth factor binding
  • is located in the following cellular components:
    • collagen type IV trimer

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Summary text based on GO annotations supported by structural data

• Col4a1 encodes a protein or proteins that contain the following InterPro domains: C-type lectin fold, Collagen IV, non-collagenous, Collagen triple helix repeat, indicating that the gene product:
  • is located in the following cellular components:
    • collagen trimer

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Col4a1 indicates that it:
  • participates in the following biological processes:
    • angiogenesis
  • is located in the following cellular components:
    • collagen trimer
    • extracellular region
    • proteinaceous extracellular matrix

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References

1. Fox MA et al. (2007) Distinct target-derived signals organize formation, maturation, and maintenance of motor nerve terminals. Cell, 129:179-93. (PubMed:17418794)
2. Gersdorff N et al. (2005) Basement membrane composition in the early mouse embryo day 7. Dev Dyn, 233:1140-1148. (PubMed:15895400)
3. Lozanoff S et al. (2001) Immunohistochemical localization of Pax2 and associated proteins in the developing kidney of mice with renal hypoplasia. J Histochem Cytochem, 49:1081-97. (PubMed:11511678)
4. Manabe R et al. (2008) Transcriptome-based systematic identification of extracellular matrix proteins. Proc Natl Acad Sci U S A, 105:12849-54. (PubMed:18757743)
5. Meyer zum Gottesberge AM et al. (2005) Abnormal basement membrane in the inner ear and the kidney of the Mpv17-/- mouse strain: ultrastructural and immunohistochemical investigations. Histochem Cell Biol, 124:507-16. (PubMed:16041630)
6. Nagai N et al. (2001) Localization of type IV collagen a 1 to a 6 chains in basement membrane during mouse molar germ development. Int J Dev Biol, 45:827-31. (PubMed:11732842)
7. Pogribny IP et al. (2010) Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice. Lab Invest, 90:1437-46. (PubMed:20548288)
8. Shindo T et al. (2002) Kruppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling. Nat Med, 8:856-63. (PubMed:12101409)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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