Automated description from the Alliance of Genome Resources
Predicted to have extracellular matrix structural constituent conferring tensile strength and platelet-derived growth factor binding activity. Involved in cellular response to amino acid stimulus; collagen-activated tyrosine kinase receptor signaling pathway; and neuromuscular junction development. Localizes to the collagen type IV trimer. Used to study COL4A1-related familial vascular leukoencephalopathy; Walker-Warburg syndrome; kidney disease; and porencephaly. Human ortholog(s) of this gene implicated in COL4A1-related familial vascular leukoencephalopathy and myocardial infarction. Is expressed in several structures, including alimentary system; brain; egg cylinder; genitourinary system; and sensory organ. Orthologous to human COL4A1 (collagen type IV alpha 1 chain).