Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Col3a1. (This text reflects annotations as of Thursday, July 24, 2014.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of September 16, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Col3a1
  • participates in the following biological processes:
    • cellular response to amino acid stimulus ^[11]
    • positive regulation of Rho protein signal transduction ^[8]
  • is located in the following cellular components:
    • collagen trimer ^{[2, 4]}
    • collagen type III trimer ^[9]
    • extracellular matrix ^{[5, 6, 10]}
• Researchers have inferred, based on physical interactions, that the gene product of Col3a1
  • performs the following molecular functions:
    • SMAD binding ^[3]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Col3a1
  • participates in the following biological processes:
    • aorta smooth muscle tissue morphogenesis ^[]
    • blood vessel development ^[7]
    • cerebral cortex development ^[8]
    • collagen fibril organization ^[7]
    • digestive tract development ^[7]
    • negative regulation of neuron migration ^[8]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Col3a1:
  • participates in the following biological processes:
    • cell-matrix adhesion
    • collagen fibril organization
    • extracellular fibril organization
    • heart development
    • integrin-mediated signaling pathway
    • negative regulation of immune response
    • peptide cross-linking
    • response to cytokine
    • response to radiation
    • skin development
    • transforming growth factor beta receptor signaling pathway
    • wound healing
  • performs the following molecular functions:
    • extracellular matrix structural constituent
    • integrin binding
    • platelet-derived growth factor binding
  • is located in the following cellular components:
    • collagen type III trimer
    • extracellular matrix
    • extracellular space

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Col3a1 indicates that it:
  • performs the following molecular functions:
    • metal ion binding
  • is located in the following cellular components:
    • extracellular region
    • proteinaceous extracellular matrix

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References

1. . () , :. (PubMed:)
2. Buck M et al. (1996) Tumor necrosis factor-alpha inhibits collagen alpha1(I) gene expression and wound healing in a murine model of cachexia. Am J Pathol, 149:195-204. (PubMed:8686743)
3. Ellis LR et al. (2003) Interaction of Smads with collagen types I, III, and V. Biochem Biophys Res Commun, 310:1117-23. (PubMed:14559231)
4. Forlino A et al. (2007) Selective retention and degradation of molecules with a single mutant alpha1(I) chain in the Brtl IV mouse model of OI. Matrix Biol, 26:604-14. (PubMed:17662583)
5. Heine UI et al. (1990) Colocalization of TGF-beta 1 and collagen I and III, fibronectin and glycosaminoglycans during lung branching morphogenesis. Development, 109:29-36. (PubMed:2209468)
6. Kim Y et al. (1999) Coexpression of the lysyl oxidase-like gene (LOXL) and the gene encoding type III procollagen in induced liver fibrosis. J Cell Biochem, 72:181-8. (PubMed:10022501)
7. Liu X et al. (1997) Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development. Proc Natl Acad Sci U S A, 94:1852-6 SS 18 /C?. (PubMed:9050868)
8. Luo R et al. (2011) G protein-coupled receptor 56 and collagen III, a receptor-ligand pair, regulates cortical development and lamination. Proc Natl Acad Sci U S A, 108:12925-30. (PubMed:21768377)
9. Ohsaki Y et al. (1994) Type III collagen is a major component of interodontoblastic fibers of the developing mouse molar root. Anat Rec, 240:308-13. (PubMed:7825727)
10. Ohsaki Y et al. (1995) Localization of types I and III collagen and fibronectin in the developing mouse palatal shelves. Acta Anat (Basel), 153:161-7. (PubMed:8984825)
11. Pogribny IP et al. (2010) Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice. Lab Invest, 90:1437-46. (PubMed:20548288)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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