Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Col3a1. (This text reflects annotations as of Tuesday, July 8, 2014.)

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Col3a1
  • participates in the following biological processes:
    • cellular response to amino acid stimulus ^[]
    • positive regulation of Rho protein signal transduction ^[]
  • is located in the following cellular components:
    • collagen trimer ^{[, ]}
    • collagen type III trimer ^[]
    • extracellular matrix ^{[, , ]}
• Researchers have inferred, based on physical interactions, that the gene product of Col3a1
  • performs the following molecular functions:
    • SMAD binding ^[]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Col3a1
  • participates in the following biological processes:
    • blood vessel development ^[]
    • cerebral cortex development ^[]
    • collagen fibril organization ^[]
    • digestive tract development ^[]
    • negative regulation of neuron migration ^[]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Col3a1:
  • participates in the following biological processes:
    • cell-matrix adhesion
    • collagen fibril organization
    • extracellular fibril organization
    • heart development
    • integrin-mediated signaling pathway
    • negative regulation of immune response
    • peptide cross-linking
    • response to cytokine
    • response to radiation
    • skin development
    • transforming growth factor beta receptor signaling pathway
    • wound healing
  • performs the following molecular functions:
    • extracellular matrix structural constituent
    • integrin binding
    • platelet-derived growth factor binding
  • is located in the following cellular components:
    • collagen type III trimer
    • extracellular matrix
    • extracellular space

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Col3a1 indicates that it:
  • performs the following molecular functions:
    • metal ion binding
  • is located in the following cellular components:
    • extracellular region
    • proteinaceous extracellular matrix

---

References

1. . () , :. (PubMed:)
2. . () , :. (PubMed:)
3. . () , :. (PubMed:)
4. . () , :. (PubMed:)
5. . () , :. (PubMed:)
6. . () , :. (PubMed:)
7. . () , :. (PubMed:)
8. . () , :. (PubMed:)
9. . () , :. (PubMed:)
10. . () , :. (PubMed:)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---