Automated description from the Alliance of Genome Resources (Release 4.0)
Enables SMAD binding activity. Involved in several processes, including aorta smooth muscle tissue morphogenesis; negative regulation of neuron migration; and positive regulation of Rho protein signal transduction. Acts upstream of or within several processes, including cellular response to amino acid stimulus; collagen fibril organization; and digestive tract development. Located in extracellular matrix. Part of collagen type III trimer. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and heart and pericardium. Used to study systemic scleroderma and vascular type Ehlers-Danlos syndrome. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome; Ehlers-Danlos syndrome hypermobility type; end stage renal disease; and vascular type Ehlers-Danlos syndrome. Orthologous to human COL3A1 (collagen type III alpha 1 chain).
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