Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cnbp. (This text reflects annotations as of Thursday, January 16, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for binding single stranded DNA and RNA. The protein functions in cap-independent translation of ornithine decarboxylase mRNA, and may also function in sterol-mediated transcriptional regulation. A CCTG expansion in the first intron of this gene results in myotonic dystrophy type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Cnbp
  • participates in the following biological processes:
    • positive regulation of cell proliferation ^[1]
    • positive regulation of transcription from RNA polymerase II promoter ^[1]
    • positive regulation of transcription, DNA-templated ^[1]
  • is located in the following cellular components:
    • cytosol ^[2]
    • endoplasmic reticulum ^[2]
    • nucleus ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Cnbp:
  • performs the following molecular functions:
    • single-stranded DNA binding
    • single-stranded RNA binding

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Summary text based on GO annotations supported by structural data

• Cnbp encodes a protein or proteins that contain the following InterPro domains: Zinc finger, CCHC-type, indicating that the gene product:
  • performs the following molecular functions:
    • nucleic acid binding
    • zinc ion binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Cnbp indicates that it:
  • participates in the following biological processes:
    • regulation of transcription, DNA-templated
    • transcription, DNA-templated
  • performs the following molecular functions:
    • DNA binding
    • metal ion binding
  • is located in the following cellular components:
    • cytoplasm

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References

1. Shimizu K et al. (2003) Molecular cloning, developmental expression, promoter analysis and functional characterization of the mouse CNBP gene. Gene, 307:51-62. (PubMed:12706888)
2. Warden CH et al. (1994) Mouse cellular nucleic acid binding proteins: a highly conserved family identified by genetic mapping and sequencing. Genomics, 24:14-9. (PubMed:7896269)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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