Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits bicarbonate transmembrane transporter activity and chloride channel activity. Involved in several processes, including cellular response to cAMP; membrane hyperpolarization; and positive regulation of transport. Localizes to apical plasma membrane; cytosol; and integral component of plasma membrane. Predicted to colocalize with early endosome. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and musculoskeletal system. Used to study cystic fibrosis. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; allergic bronchopulmonary aspergillosis; bronchial disease (multiple); congenital bilateral absence of vas deferens (multiple); and lung disease (multiple). Orthologous to human CFTR (CF transmembrane conductance regulator).