Automated description from the Alliance of Genome Resources
Exhibits bicarbonate transmembrane transporter activity and chloride channel activity. Involved in several processes, including cellular response to cAMP; membrane hyperpolarization; and positive regulation of transport. Localizes to the apical plasma membrane; cytosol; and integral component of plasma membrane. Used to study cystic fibrosis. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; allergic bronchopulmonary aspergillosis; bronchial disease (multiple); cystic fibrosis; and lung disease (multiple). Orthologous to human CFTR (CF transmembrane conductance regulator).