Automated description from the Alliance of Genome Resources (Release 4.0)
Enables bicarbonate transmembrane transporter activity; chloride channel activity; and chloride transmembrane transporter activity. Involved in several processes, including cellular response to cAMP; chloride transmembrane transport; and positive regulation of transport. Acts upstream of or within chloride transport; cholesterol biosynthetic process; and cholesterol transport. Located in apical plasma membrane and cytosol. Is integral component of plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and musculoskeletal system. Used to study cystic fibrosis. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; allergic bronchopulmonary aspergillosis; bronchial disease (multiple); congenital bilateral absence of vas deferens (multiple); and lung disease (multiple). Orthologous to human CFTR (CF transmembrane conductance regulator).