Automated description from the Alliance of Genome Resources
Exhibits complement component C3b binding activity and heparin binding activity. Involved in positive regulation of cytolysis and regulation of complement activation. Localizes to the extracellular space. Used to study age related macular degeneration 4; atypical hemolytic-uremic syndrome; hemolytic-uremic syndrome; and membranoproliferative glomerulonephritis. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; eye disease (multiple); hemolytic-uremic syndrome; lupus nephritis; and systemic lupus erythematosus. Is expressed in several structures, including adrenal gland; bone; central nervous system; humerus cartilage condensation; and metanephros. Orthologous to human CFH (complement factor H).