Automated description from the Alliance of Genome Resources (Release 3.2)
Exhibits complement component C3b binding activity and heparin binding activity. Involved in several processes, including animal organ development; complement activation; and vasculature development. Localizes to several cellular components, including axon; external side of plasma membrane; and neuronal cell body. Is expressed in several structures, including adrenal gland; bone; central nervous system; humerus cartilage condensation; and metanephros. Used to study age related macular degeneration 4; atypical hemolytic-uremic syndrome; hemolytic-uremic syndrome; and membranoproliferative glomerulonephritis. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; atypical hemolytic-uremic syndrome; eye disease (multiple); hemolytic-uremic syndrome; and lupus nephritis. Orthologous to several human genes including CFH (complement factor H).