Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of F9. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of F9
  • participates in the following biological processes:
    • metabolic process ^[1]
  • performs the following molecular functions:
    • peptidase activity ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of F9
  • participates in the following biological processes:
    • blood coagulation ^[1]

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Summary text based on GO annotations supported by structural data

• F9 encodes a protein or proteins that contain the following InterPro domains: Coagulation factor, subgroup, Gla domain, EGF-like calcium-binding, EGF-like calcium-binding, conserved site, EGF-like, conserved site, EGF-type aspartate/asparagine hydroxylation site, Epidermal growth factor-like domain, Gamma-carboxyglutamic acid-rich (GLA) domain, Peptidase S1, Peptidase S1, trypsin family, active site, Peptidase S1A, chymotrypsin-type, Peptidase S1A, coagulation factor VII/IX/X/C/Z, Trypsin-like cysteine/serine peptidase domain, indicating that the gene product:
  • participates in the following biological processes:
    • proteolysis
  • performs the following molecular functions:
    • calcium ion binding
    • catalytic activity
    • serine-type endopeptidase activity
  • is located in the following cellular components:
    • extracellular region

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe F9 indicates that it:
  • participates in the following biological processes:
    • hemostasis
    • proteolysis
  • performs the following molecular functions:
    • hydrolase activity
    • serine-type peptidase activity
  • is located in the following cellular components:
    • extracellular region

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References

1. Jin DY et al. (2004) Creation of a mouse expressing defective human factor IX. Blood, 104:1733-9. (PubMed:15178576)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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