Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of F8. (This text reflects annotations as of Wednesday, January 23, 2013.)

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of F8:
  • participates in the following biological processes:
    • blood coagulation
    • blood coagulation, intrinsic pathway
  • performs the following molecular functions:
    • serine-type endopeptidase activity
  • is located in the following cellular components:
    • extracellular space

---

Summary text based on GO annotations supported by structural data

• F8 encodes a protein or proteins that contain the following InterPro domains: Coagulation factor 5/8, Coagulation factor 5/8 C-terminal type domain, Coagulation factor 8, Cupredoxin, Galactose-binding domain-like, Multicopper oxidase, copper-binding site, Multicopper oxidase, type 1, Multicopper oxidase, type 2, Multicopper oxidase, type 3, indicating that the gene product:
  • participates in the following biological processes:
    • cell adhesion
    • oxidation-reduction process
    • platelet activation
  • performs the following molecular functions:
    • copper ion binding
    • oxidoreductase activity

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe F8 indicates that it:
  • participates in the following biological processes:
    • acute-phase response
    • hemostasis
    • oxidation-reduction process
  • performs the following molecular functions:
    • metal ion binding
    • oxidoreductase activity
  • is located in the following cellular components:
    • extracellular region

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---