Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits enzyme activator activity and serine-type endopeptidase activity. Involved in several processes, including platelet activation; positive regulation of cell growth; and positive regulation of phosphatidylinositol 3-kinase signaling. Localizes to collagen-containing extracellular matrix. Predicted to colocalize with external side of plasma membrane. Is expressed in embryo; liver; liver lobe; skeletal muscle; and testis. Human ortholog(s) of this gene implicated in several diseases, including appendicitis; artery disease (multiple); autoimmune hypersensitivity disease (multiple); inherited blood coagulation disease (multiple); and thrombophilia (multiple). Orthologous to human F2 (coagulation factor II, thrombin).