Automated description from the Alliance of Genome Resources
Exhibits enzyme activator activity and serine-type endopeptidase activity. Involved in several processes, including platelet activation; positive regulation of phosphatidylinositol 3-kinase signaling; and regulation of cell shape. Localizes to the collagen-containing extracellular matrix. Predicted to colocalize with the external side of plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including X-linked recessive disease (multiple); appendicitis; artery disease (multiple); autoimmune hypersensitivity disease (multiple); and thrombophilia (multiple). Is expressed in embryo; liver; liver lobe; skeletal muscle; and testis. Orthologous to human F2 (coagulation factor II, thrombin).