Automated description from the Alliance of Genome Resources (Release 4.1.0)
Enables serine-type endopeptidase activity. Acts upstream of or within several processes, including platelet activation; positive regulation of cell growth; and positive regulation of phosphatidylinositol 3-kinase signaling. Located in collagen-containing extracellular matrix. Is expressed in several structures, including liver; musculoskeletal system; and testis. Human ortholog(s) of this gene implicated in several diseases, including X-linked recessive disease (multiple); appendicitis; artery disease (multiple); autoimmune disease (multiple); and thrombophilia (multiple). Orthologous to human F2 (coagulation factor II, thrombin).