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Gene Ontology Classifications
cyclin-dependent kinase 4

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cdk4. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Aggarwal P et al. (2010) Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase. Cancer Cell, 18:329-40. (PubMed:20951943)
  2. Barbash O et al. (2009) Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradation. Oncogene, 28:4317-25. (PubMed:19767775)
  3. Cam H et al. (2006) p53 family members in myogenic differentiation and rhabdomyosarcoma development. Cancer Cell, 10:281-93. (PubMed:17045206)
  4. Capaldo CT et al. (2011) Tight function zonula occludens-3 regulates cyclin D1-dependent cell proliferation. Mol Biol Cell, 22:1677-85. (PubMed:21411630)
  5. Diehl JA et al. (2003) Hsc70 regulates accumulation of cyclin D1 and cyclin D1-dependent protein kinase. Mol Cell Biol, 23:1764-74. (PubMed:12588994)
  6. Drosten M et al. (2010) Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival. EMBO J, 29:1091-104. (PubMed:20150892)
  7. Fernandez RM et al. (2011) Cyclin D1 interacts and collaborates with Ral GTPases enhancing cell detachment and motility. Oncogene, 30:1936-46. (PubMed:21242975)
  8. Hu MG et al. (2011) CDK6 kinase activity is required for thymocyte development. Blood, 117:6120-31. (PubMed:21508411)
  9. Hurlin PJ et al. (2003) Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis. EMBO J, 22:4584-96. (PubMed:12970171)
  10. Izeradjene K et al. (2007) Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas. Cancer Cell, 11:229-43. (PubMed:17349581)
  11. Landis MW et al. (2006) Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis. Cancer Cell, 9:13-22. (PubMed:16413468)
  12. Lazaro JB et al. (2002) Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation. Genes Dev, 16:1792-805. (PubMed:12130539)
  13. Liu Y et al. (2007) Somatic cell type specific gene transfer reveals a tumor-promoting function for p21(Waf1/Cip1). EMBO J, 26:4683-93. (PubMed:17948060)
  14. Martin J et al. (2003) Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number. Oncogene, 22:5261-9. (PubMed:12917627)
  15. Mori M et al. (2011) Death effector domain-containing protein (DEDD) is required for uterine decidualization during early pregnancy in mice. J Clin Invest, 121:318-27. (PubMed:21135503)
  16. Murakami H et al. (2009) Isolation and characterization of cytoplasmic cyclin D1 mutants. FEBS Lett, 583:1575-80. (PubMed:19409388)
  17. Park YK et al. (2005) Gene expression profile analysis of mouse colon embryonic development. Genesis, 41:1-12. (PubMed:15645444)
  18. Timchenko NA et al. (1999) C/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice. Mol Cell Biol, 19:2936-45. (PubMed:10082561)
  19. Toyoshima H et al. (1994) p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell, 78:67-74. (PubMed:8033213)
  20. Vairapandi M et al. (2002) GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress. J Cell Physiol, 192:327-38. (PubMed:12124778)
  21. Wang GL et al. (2004) Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity. Genes Dev, 18:912-25. (PubMed:15107404)
  22. Woo M et al. (2003) Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity. Nat Immunol, 4:1016-22. (PubMed:12970760)
  23. Yu Q et al. (2006) Requirement for CDK4 kinase function in breast cancer. Cancer Cell, 9:23-32. (PubMed:16413469)
  24. Zhang T et al. (1997) Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (Min) mice and human familial adenomatous polyposis patients. Cancer Res, 57:169-75. (PubMed:8988060)

Go Annotations in Tabular Form (Text View) (GO Graph)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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