Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Involved in several processes, including cellular response to interleukin-4; cellular response to lipid; and regulation of lipid metabolic process. Localizes to several cellular components, including cyclin D2-CDK4 complex; nucleus; and transcription regulator complex. Colocalizes with bicellular tight junction. Is expressed in several structures, including alimentary system; branchial arch; genitourinary system; nervous system; and sensory organ. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); familial melanoma; glioblastoma multiforme; obesity; and type 2 diabetes mellitus. Orthologous to human CDK4 (cyclin dependent kinase 4).