Automated description from the Alliance of Genome Resources (Release 3.0)
Exhibits hyaluronic acid binding activity and type II transforming growth factor beta receptor binding activity. Contributes to cytokine binding activity and cytokine receptor activity. Involved in several processes, including negative regulation of T cell activation; negative regulation of signal transduction by p53 class mediator; and positive regulation of protein phosphorylation. Localizes to several cellular components, including basolateral plasma membrane; external side of plasma membrane; and macrophage migration inhibitory factor receptor complex. Human ortholog(s) of this gene implicated in breast carcinoma (multiple); carcinoma (multiple); cholestasis; and prostate cancer. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; limb; and urethra. Orthologous to human CD44 (CD44 molecule (Indian blood group)).