Automated description from the Alliance of Genome Resources (Release 3.2)
Predicted to have antigen binding activity; protein domain specific binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including defense response to other organism; positive regulation of B cell activation; and positive regulation of interleukin-12 production. Localizes to CD40 receptor complex; external side of plasma membrane; and intracellular membrane-bounded organelle. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and limb. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); end stage renal disease; hyperimmunoglobulin syndrome (multiple); and non-Hodgkin lymphoma (multiple). Orthologous to human CD40 (CD40 molecule).
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