Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cd40. (This text reflects annotations as of Tuesday, July 8, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Cd40
  • participates in the following biological processes:
    • B cell activation ^{[, ]}
    • defense response to virus ^[]
    • immune response-regulating cell surface receptor signaling pathway ^[]
    • positive regulation of B cell proliferation ^{[, , , , ]}
    • positive regulation of interleukin-12 production ^[]
    • positive regulation of isotype switching to IgG isotypes ^[]
    • protein kinase B signaling ^[]
    • regulation of immune response ^[]
    • regulation of immunoglobulin secretion ^[]
  • is located in the following cellular components:
    • CD40 receptor complex ^[]
    • cell surface ^[]
    • external side of plasma membrane ^{[, , , , , ]}
    • intracellular membrane-bounded organelle ^[]
    • plasma membrane ^[]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Cd40
  • participates in the following biological processes:
    • cellular calcium ion homeostasis ^[]
• Researchers have inferred, based on genetic interactions, that the gene product of Cd40
  • participates in the following biological processes:
    • positive regulation of B cell proliferation based on interactions with Chrnb2 ^[]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Cd40:
  • participates in the following biological processes:
    • cellular calcium ion homeostasis
    • inflammatory response
    • positive regulation of Cdc42 GTPase activity
    • positive regulation of endothelial cell apoptotic process
    • positive regulation of MAP kinase activity
    • positive regulation of NF-kappaB transcription factor activity
    • positive regulation of protein kinase C signaling
    • positive regulation of protein phosphorylation
    • positive regulation of Rac GTPase activity
    • positive regulation of transcription from RNA polymerase II promoter
    • positive regulation of tyrosine phosphorylation of Stat1 protein
  • performs the following molecular functions:
    • antigen binding
    • enzyme binding
    • ubiquitin protein ligase binding
  • is located in the following cellular components:
    • CD40 receptor complex
    • cell surface
    • cytoplasm
    • extracellular space
    • extracellular vesicular exosome
    • plasma membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Cd40 indicates that it:
  • participates in the following biological processes:
    • immune system process
  • is located in the following cellular components:
    • extracellular region
    • integral component of membrane
    • membrane

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References

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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