Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cd247. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Cd247
  • participates in the following biological processes:
    • T cell receptor signaling pathway ^[1]
  • is located in the following cellular components:
    • alpha-beta T cell receptor complex ^{[4, 5]}
• The gene product of Cd247 has been shown to bind to the gene products of Cd3e, Zap70. ^{[2, 3]}

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Cd247:
  • participates in the following biological processes:
    • cell surface receptor signaling pathway
  • performs the following molecular functions:
    • identical protein binding
  • is located in the following cellular components:
    • cytoplasm
    • plasma membrane
    • T cell receptor complex

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Summary text based on GO annotations supported by structural data

• Cd247 encodes a protein or proteins that contain the following InterPro domains: Phosphorylated immunoreceptor signaling ITAM, T-cell surface glycoprotein CD3 zeta/eta subunit, T-cell surface glycoprotein CD3 zeta/eta subunit/High affinity IgE receptor gamma subunit, indicating that the gene product:
  • participates in the following biological processes:
    • signal transduction
  • performs the following molecular functions:
    • transmembrane signaling receptor activity
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Cd247 indicates that it:
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Apasov SG et al. (2001) Adenosine deaminase deficiency increases thymic apoptosis and causes defective T cell receptor signaling. J Clin Invest, 108:131-41. (PubMed:11435465)
2. Gauen LK et al. (1994) Interactions of p59fyn and ZAP-70 with T-cell receptor activation motifs: defining the nature of a signalling motif. Mol Cell Biol, 14:3729-41. (PubMed:8196616)
3. Kirchgessner H et al. (2001) The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain. J Exp Med, 193:1269-84. (PubMed:11390434)
4. Pani G et al. (1996) Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase. J Exp Med, 184:839-52. (PubMed:9064344)
5. Wiest DL et al. (1997) A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development. Immunity, 6:663-71. (PubMed:9208839)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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