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Gene Ontology Classifications
Symbol
Name
ID
Ccne1
cyclin E1
MGI:88316

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Automated description from the Alliance of Genome Resources

Exhibits cyclin-dependent protein serine/threonine kinase regulator activity; kinase activity; and protein kinase binding activity. Predicted to contribute to protein kinase activity. Involved in several processes, including DNA metabolic process; negative regulation of transcription by RNA polymerase II; and synapsis. Localizes to the cyclin E1-CDK2 complex and nucleus. Human ortholog(s) of this gene implicated in breast adenocarcinoma. Is expressed in several structures, including Rathke's pouch; brain; early conceptus; eye; and spinal cord. Orthologous to human CCNE1 (cyclin E1).



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Gene Ontology Evidence Code Abbreviations:

Experimental:
EXP
Inferred from experiment
HMP
Inferred from high throughput mutant phenotype
HGI
Inferred from high throughput genetic interaction
HDA
Inferred from high throughput direct assay
HEP
Inferred from high throughput expression pattern
IDA
Inferred from direct assay
IEP
Inferred from expression pattern
IGI
Inferred from genetic interaction
IMP
Inferred from mutant phenotype
IPI
Inferred from physical interaction
Homology:
IAS
Inferred from ancestral sequence
IBA
Inferred from biological aspect of ancestor
IBD
Inferred from biological aspect of descendant
IKR
Inferred from key residues
IMR
Inferred from missing residues
IRD
Inferred from rapid divergence
ISA
Inferred from sequence alignment
ISM
Inferred from sequence model
ISO
Inferred from sequence orthology
ISS
Inferred from sequence or structural similarity
Automated:
IEA
Inferred from electronic annotation
RCA
Reviewed computational analysis
Other:
IC
Inferred by curator
NAS
Non-traceable author statement
ND
No biological data available
TAS
Traceable author statement

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Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory