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Gene Ontology Classifications
catenin (cadherin associated protein), beta 1

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ctnnb1. (This text reflects annotations as of Tuesday, May 26, 2015.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of March 26, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq

This gene encodes not only an important cytoplasmic component of the classical cadherin adhesion complex that forms the adherens junction in epithelia and mediates cell-cell adhesion in many other tissues but also a key signaling molecule in the canonical Wnt signaling pathway that controls cell growth and differentiation during both normal development and tumorigenesis. The gene product contains a central armadillo-repeat containing domain through which it binds the cytoplasmic tail of classical cadherins; meanwhile, it also binds alpha-catenin, which further links the cadherin complex to the actin cytoskeleton either directly or indirectly. Beta-catenin is therefore necessary for the adhesive function of classical cadherins. Another key function of this protein is to mediate the canonical Wnt signaling pathway and regulate gene transcription. Without Wnt signal, cytoplasmic beta-catenin that is not associated with the cadherin complex is quickly phosphorylated at the N-terminal Ser/Thr residues by the so called degradation complex containing axin, adenomatous polyposis coli (APC), casein kinase I, and GSK3B, then ubiquitylated by beta-TrCP, and degraded by the proteasome. However, in the presence of Wnt signal, the degradation complex is disrupted and the stabilized cytoplasmic beta-catenin translocates into the nucleus, where it binds various transcription factors and, together with these factors, regulates the transcription of many downstream genes. Mutations of this gene have been linked with various types of tumors. Alternatively spliced variants have been found for this gene. [provided by RefSeq, Sep 2009]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Adachi S et al. (2004) Role of a BCL9-related beta-catenin-binding protein, B9L, in tumorigenesis induced by aberrant activation of Wnt signaling. Cancer Res, 64:8496-501. (PubMed:15574752)
  2. Adolphe C et al. (2006) Patched1 functions as a gatekeeper by promoting cell cycle progression. Cancer Res, 66:2081-8. (PubMed:16489008)
  3. Armstrong A et al. (2011) Frizzled3 Is Required for Neurogenesis and Target Innervation during Sympathetic Nervous System Development. J Neurosci, 31:2371-81. (PubMed:21325504)
  4. Backman M et al. (2005) Effects of canonical Wnt signaling on dorso-ventral specification of the mouse telencephalon. Dev Biol, 279:155-68. (PubMed:15708565)
  5. Bamji SX et al. (2003) Role of beta-catenin in synaptic vesicle localization and presynaptic assembly. Neuron, 40:719-31. (PubMed:14622577)
  6. Barrow JR et al. (2003) Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge. Genes Dev, 17:394-409. (PubMed:12569130)
  7. Behrens J et al. (1998) Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta. Science, 280:596-9. (PubMed:9554852)
  8. Bek S et al. (2002) Protein kinase CKII regulates the interaction of beta-catenin with alpha-catenin and its protein stability. J Cell Sci, 115:4743-53. (PubMed:12432063)
  9. Bell SM et al. (2013) Kruppel-like factor 5 controls villus formation and initiation of cytodifferentiation in the embryonic intestinal epithelium. Dev Biol, 375:128-39. (PubMed:23266329)
  10. Benhamouche S et al. (2006) Apc tumor suppressor gene is the 'zonation-keeper' of mouse liver. Dev Cell, 10:759-70. (PubMed:16740478)
  11. Bennett CN et al. (2002) Regulation of Wnt signaling during adipogenesis. J Biol Chem, 277:30998-1004. (PubMed:12055200)
  12. Bennett PM et al. (2006) The transitional junction: a new functional subcellular domain at the intercalated disc. Mol Biol Cell, 17:2091-100. (PubMed:16481394)
  13. Besco JA et al. (2006) Intracellular substrates of brain-enriched receptor protein tyrosine phosphatase rho (RPTPrho/PTPRT). Brain Res, 1116:50-7. (PubMed:16973135)
  14. Bierie B et al. (2003) Activation of beta-catenin in prostate epithelium induces hyperplasias and squamous transdifferentiation. Oncogene, 22:3875-87. (PubMed:12813461)
  15. Boras-Granic K et al. (2006) Lef1 is required for the transition of Wnt signaling from mesenchymal to epithelial cells in the mouse embryonic mammary gland. Dev Biol, 295:219-31. (PubMed:16678815)
  16. Borello U et al. (2006) The Wnt/{beta}-catenin pathway regulates Gli-mediated Myf5 expression during somitogenesis. Development, 133:3723-32. (PubMed:16936075)
  17. Bort R et al. (2006) Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development. Dev Biol, 290:44-56. (PubMed:16364283)
  18. Buchman JJ et al. (2011) ASPM regulates Wnt signaling pathway activity in the developing brain. Genes Dev, 25:1909-14. (PubMed:21937711)
  19. Burkart A et al. (2003) Regulation of the SHP-2 tyrosine phosphatase by a novel cholesterol- and cell confluence-dependent mechanism. J Biol Chem, 278:18360-7. (PubMed:12611902)
  20. Butz S et al. (1995) Expression of catenins during mouse embryonic development and in adult tissues. Cell Adhes Commun, 3:337-52. (PubMed:8821035)
  21. Cano DA et al. (2004) Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization. Development, 131:3457-67. (PubMed:15226261)
  22. Cappello S et al. (2006) The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface. Nat Neurosci, 9:1099-107. (PubMed:16892058)
  23. Carothers AM et al. (2006) Deficient E-cadherin adhesion in C57BL/6J-Min/+ mice is associated with increased tyrosine kinase activity and RhoA-dependent actomyosin contractility. Exp Cell Res, 312:387-400. (PubMed:16368433)
  24. Cattelino A et al. (2003) The conditional inactivation of the beta-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility. J Cell Biol, 162:1111-22. (PubMed:12975353)
  25. Chae TH et al. (2004) The hyh mutation uncovers roles for alpha Snap in apical protein localization and control of neural cell fate. Nat Genet, 36:264-70. (PubMed:14758363)
  26. Chalamalasetty RB et al. (2011) The Wnt3a/beta-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signalling program. Nat Commun, 2:390. (PubMed:21750544)
  27. Chassot AA et al. (2011) RSPO1/beta-catenin signaling pathway regulates oogonia differentiation and entry into meiosis in the mouse fetal ovary. PLoS One, 6:e25641. (PubMed:21991325)
  28. Chen CM et al. (2010) Expression analysis of an evolutionary conserved metallophosphodiesterase gene, Mpped1, in the normal and beta-catenin-deficient malformed dorsal telencephalon. Dev Dyn, 239:1797-806. (PubMed:20503375)
  29. Chia IV et al. (2009) Both the RGS Domain and the Six C-Terminal Amino Acids of Mouse Axin Are Required for Normal Embryogenesis. Genetics, 181:1359-68. (PubMed:19204372)
  30. Choi HJ et al. (2006) Thermodynamics of beta-catenin-ligand interactions: the roles of the N- and C-terminal tails in modulating binding affinity. J Biol Chem, 281:1027-38. (PubMed:16293619)
  31. Cohen ED et al. (2009) Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway. J Clin Invest, 119:2538-49. (PubMed:19690384)
  32. Cong F et al. (2004) Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of beta-catenin. Proc Natl Acad Sci U S A, 101:2882-7. (PubMed:14981260)
  33. Conti MA et al. (2004) Defects in cell adhesion and the visceral endoderm following ablation of nonmuscle myosin heavy chain II-A in mice. J Biol Chem, 279:41263-6. (PubMed:15292239)
  34. Corada M et al. (2010) The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling. Dev Cell, 18:938-49. (PubMed:20627076)
  35. Daneman R et al. (2009) Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis. Proc Natl Acad Sci U S A, 106:641-6. (PubMed:19129494)
  36. Daniels DL et al. (2002) ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules. Mol Cell, 10:573-84. (PubMed:12408825)
  37. De Langhe SP et al. (2006) Levels of mesenchymal FGFR2 signaling modulate smooth muscle progenitor cell commitment in the lung. Dev Biol, 299:52-62. (PubMed:16989802)
  38. De Langhe SP et al. (2008) Formation and Differentiation of Multiple Mesenchymal Lineages during Lung Development Is Regulated by beta-catenin Signaling. PLoS ONE, 3:e1516. (PubMed:18231602)
  39. Den Z et al. (2006) Desmocollin 3 is required for pre-implantation development of the mouse embryo. J Cell Sci, 119:482-9. (PubMed:16418220)
  40. Deutscher E et al. (2007) Essential roles of mesenchyme-derived beta-catenin in mouse Mullerian duct morphogenesis. Dev Biol, 307:227-36. (PubMed:17532316)
  41. Dickinson DJ et al. (2011) A polarized epithelium organized by beta- and alpha-catenin predates cadherin and metazoan origins. Science, 331:1336-9. (PubMed:21393547)
  42. Ellis T et al. (2003) Overexpression of Sonic Hedgehog suppresses embryonic hair follicle morphogenesis. Dev Biol, 263:203-15. (PubMed:14597196)
  43. Engert S et al. (2013) Wnt/beta-catenin signalling regulates Sox17 expression and is essential for organizer and endoderm formation in the mouse. Development, 140:3128-38. (PubMed:23824574)
  44. Etournay R et al. (2007) Shroom2, a myosin-VIIa- and actin-binding protein, directly interacts with ZO-1 at tight junctions. J Cell Sci, 120:2838-50. (PubMed:17666436)
  45. Fancy SP et al. (2009) Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS. Genes Dev, 23:1571-85. (PubMed:19515974)
  46. Friedman MS et al. (2009) Wnt11 promotes osteoblast maturation and mineralization through R-spondin 2. J Biol Chem, 284:14117-25. (PubMed:19213727)
  47. Galceran J et al. (2000) Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1. Development, 127:469-82. (PubMed:10631168)
  48. Gao N et al. (2005) Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation. Development, 132:3431-43. (PubMed:15987773)
  49. Gao Y et al. (2011) The zinc finger transcription factors Osr1 and Osr2 control synovial joint formation. Dev Biol, 352:83-91. (PubMed:21262216)
  50. Gavard J et al. (2004) Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways. J Cell Sci, 117:257-70. (PubMed:14657280)
  51. Ghaleb AM et al. (2007) Haploinsufficiency of Kruppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis. Cancer Res, 67:7147-54. (PubMed:17671182)
  52. Glass DA 2nd et al. (2005) Canonical wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell, 8:751-64. (PubMed:15866165)
  53. Godin JD et al. (2010) Mutant huntingtin-impaired degradation of beta-catenin causes neurotoxicity in Huntington's disease. EMBO J, 29:2433-45. (PubMed:20531388)
  54. Gold DA et al. (2003) RORalpha coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways. Neuron, 40:1119-31. (PubMed:14687547)
  55. Goodall J et al. (2004) Brn-2 expression controls melanoma proliferation and is directly regulated by beta-catenin. Mol Cell Biol, 24:2915-22. (PubMed:15024079)
  56. Goossens S et al. (2007) A unique and specific interaction between alphaT-catenin and plakophilin-2 in the area composita, the mixed-type junctional structure of cardiac intercalated discs. J Cell Sci, 120:2126-36. (PubMed:17535849)
  57. Goss AM et al. (2009) Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut. Dev Cell, 17:290-8. (PubMed:19686689)
  58. Gounari F et al. (2005) Loss of adenomatous polyposis coli gene function disrupts thymic development. Nat Immunol, 6:800-9. (PubMed:16025118)
  59. Grimsley-Myers CM et al. (2009) The small GTPase Rac1 regulates auditory hair cell morphogenesis. J Neurosci, 29:15859-69. (PubMed:20016102)
  60. Grote D et al. (2008) Gata3 acts downstream of beta-catenin signaling to prevent ectopic metanephric kidney induction. PLoS Genet, 4:e1000316. (PubMed:19112489)
  61. Guillaume E et al. (2013) Flotillin microdomains stabilize cadherins at cell-cell junctions. J Cell Sci, 126:5293-304. (PubMed:24046456)
  62. Guo X et al. (2004) Wnt/beta-catenin signaling is sufficient and necessary for synovial joint formation. Genes Dev, 18:2404-17. (PubMed:15371327)
  63. Ha NC et al. (2004) Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation. Mol Cell, 15:511-21. (PubMed:15327768)
  64. Hadjihannas MV et al. (2010) Conductin/axin2 and Wnt signalling regulates centrosome cohesion. EMBO Rep, 11:317-24. (PubMed:20300119)
  65. Haegel H et al. (1995) Lack of beta-catenin affects mouse development at gastrulation. Development, 121:3529-37. (PubMed:8582267)
  66. Harris-Johnson KS et al. (2009) beta-Catenin promotes respiratory progenitor identity in mouse foregut. Proc Natl Acad Sci U S A, 106:16287-92. (PubMed:19805295)
  67. Hata T et al. (2007) Targeted disruption of the murine large nuclear KIAA1440/Ints1 protein causes growth arrest in early blastocyst stage embryos and eventual apoptotic cell death. Biochim Biophys Acta, 1773:1039-51. (PubMed:17544522)
  68. Heallen T et al. (2011) Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size. Science, 332:458-61. (PubMed:21512031)
  69. Hildebrand JD. (2005) Shroom regulates epithelial cell shape via the apical positioning of an actomyosin network. J Cell Sci, 118:5191-203. (PubMed:16249236)
  70. Hill TP et al. (2005) Canonical Wnt/beta-Catenin Signaling Prevents Osteoblasts from Differentiating into Chondrocytes. Dev Cell, 8:727-38. (PubMed:15866163)
  71. Hoffmeyer K et al. (2012) Wnt/beta-catenin signaling regulates telomerase in stem cells and cancer cells. Science, 336:1549-54. (PubMed:22723415)
  72. Holmen SL et al. (2005) Essential role of beta-catenin in postnatal bone acquisition. J Biol Chem, 280:21162-8. (PubMed:15802266)
  73. Hu H et al. (2005) Sequential roles of Hedgehog and Wnt signaling in osteoblast development. Development, 132:49-60. (PubMed:15576404)
  74. Huang T et al. (2003) Foxj1 is required for apical localization of ezrin in airway epithelial cells. J Cell Sci, 116:4935-45. (PubMed:14625387)
  75. Huber AH et al. (2001) The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin. Cell, 105:391-402. (PubMed:11348595)
  76. Huber O et al. (1997) A specific domain in alpha-catenin mediates binding to beta-catenin or plakoglobin. J Cell Sci, 110:1759-65. (PubMed:9264463)
  77. Huelsken J et al. (2001) beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell, 105:533-45. (PubMed:11371349)
  78. Huelsken J et al. (2000) Requirement for beta-catenin in anterior-posterior axis formation in mice. J Cell Biol, 148:567-78. (PubMed:10662781)
  79. Hulit J et al. (2004) Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice. (Erratum: v 25(1):523) Mol Cell Biol, 24:7598-611. (PubMed:15314168)
  80. Hyenne V et al. (2005) Vezatin, a protein associated to adherens junctions, is required for mouse blastocyst morphogenesis. Dev Biol, 287:180-91. (PubMed:16199027)
  81. Ireland H et al. (2004) Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin. Gastroenterology, 126:1236-46. (PubMed:15131783)
  82. Ito T et al. (2009) Arginine methyltransferase CARM1/PRMT4 regulates endochondral ossification. BMC Dev Biol, 9:47. (PubMed:19725955)
  83. Janssens B et al. (2001) alphaT-catenin: a novel tissue-specific beta-catenin-binding protein mediating strong cell-cell adhesion. J Cell Sci, 114:3177-88. (PubMed:11590244)
  84. Johansson A et al. (2000) The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1. J Cell Sci, 113:3267-75. (PubMed:10954424)
  85. Jordan BK et al. (2003) Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/beta-catenin synergy. Proc Natl Acad Sci U S A, 100:10866-71. (PubMed:12949260)
  86. Kahler RA et al. (2003) Lymphoid enhancer factor-1 and beta-catenin inhibit Runx2-dependent transcriptional activation of the osteocalcin promoter. J Biol Chem, 278:11937-44. (PubMed:12551949)
  87. Kanamori M et al. (2003) The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells. J Biol Chem, 278:38758-64. (PubMed:12874278)
  88. Karner CM et al. (2011) Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development. Development, 138:1247-57. (PubMed:21350016)
  89. Kawajiri A et al. (2000) Identification of a novel beta-catenin-interacting protein. Biochem Biophys Res Commun, 273:712-7. (PubMed:10873669)
  90. Kelly JM et al. (2007) Effects of grade of oocyte-cumulus complex and the interactions between grades on the production of blastocysts in the cow, ewe and lamb. Reprod Domest Anim, 42:577-82. (PubMed:17976063)
  91. Kemler R et al. (2004) Stabilization of {beta}-catenin in the mouse zygote leads to premature epithelial-mesenchymal transition in the epiblast. Development, 131:5817-5824. (PubMed:15525667)
  92. Kennell JA et al. (2003) T-cell factor 4N (TCF-4N), a novel isoform of mouse TCF-4, synergizes with beta-catenin to coactivate C/EBPalpha and steroidogenic factor 1 transcription factors. Mol Cell Biol, 23:5366-75. (PubMed:12861022)
  93. Kim MJ et al. (2008) SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability. FASEB J, 22:3785-94. (PubMed:18632848)
  94. Kimura T et al. (2006) The stabilization of beta-catenin leads to impaired primordial germ cell development via aberrant cell cycle progression. Dev Biol, 300:545-53. (PubMed:17055474)
  95. Kioussi C et al. (2002) Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 Pathway Mediating Cell-Type-Specific Proliferation during Development. Cell, 111:673-85. (PubMed:12464179)
  96. Kirschenbaum F et al. (2001) Substitution of a Glycogen Synthase Kinase-3beta Phosphorylation Site in Presenilin 1 Separates Presenilin Function from beta -Catenin Signaling. J Biol Chem, 276:7366-75. (PubMed:11104755)
  97. Klezovitch O et al. (2004) Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice. Genes Dev, 18:559-71. (PubMed:15037549)
  98. Kobielak A et al. (2004) Mammalian formin-1 participates in adherens junctions and polymerization of linear actin cables. Nat Cell Biol, 6:21-30. (PubMed:14647292)
  99. Korinek V et al. (1998) Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse. Mol Cell Biol, 18:1248-56. (PubMed:9488439)
  100. Kwon C et al. (2009) A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate. Nat Cell Biol, 11:951-7. (PubMed:19620969)
  101. Lallemand D et al. (2003) NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions. Genes Dev, 17:1090-100. (PubMed:12695331)
  102. Lang D et al. (2005) Pax3 functions at a nodal point in melanocyte stem cell differentiation. Nature, 433:884-7. (PubMed:15729346)
  103. Lavado A et al. (2013) Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators. Development, 140:3323-34. (PubMed:23863479)
  104. Le Grand F et al. (2009) Wnt7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cells. Cell Stem Cell, 4:535-47. (PubMed:19497282)
  105. Li W et al. (2015) Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway. Proc Natl Acad Sci U S A, 112:166-71. (PubMed:25535395)
  106. Li Y et al. (2008) Bmp4 is required for tracheal formation: a novel mouse model for tracheal agenesis. Dev Biol, 322:145-55. (PubMed:18692041)
  107. Lickert H et al. (2002) Formation of multiple hearts in mice following deletion of beta-catenin in the embryonic endoderm. Dev Cell, 3:171-81. (PubMed:12194849)
  108. Lim BK et al. (2008) Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart. J Clin Invest, 118:2758-70. (PubMed:18636119)
  109. Lin C et al. (2008) Tissue-specific requirements of beta-catenin in external genitalia development. Development, 135:2815-25. (PubMed:18635608)
  110. Liu CF et al. (2010) WNT4/beta-catenin pathway maintains female germ cell survival by inhibiting activin betaB in the mouse fetal ovary. PLoS One, 5:e10382. (PubMed:20454446)
  111. Liu F et al. (2007) Wnt-beta-catenin signaling initiates taste papilla development. Nat Genet, 39:106-12. (PubMed:17128274)
  112. Liu X et al. (2010) Sox17 modulates Wnt3A/beta-catenin-mediated transcriptional activation of the Lef-1 promoter. Am J Physiol Lung Cell Mol Physiol, 299:L694-710. (PubMed:20802155)
  113. Lu J et al. (2013) A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta. PLoS Biol, 11:e1001536. (PubMed:23610556)
  114. Lu Z et al. (2008) Protein encoded by the Axin(Fu) allele effectively down-regulates Wnt signaling but exerts a dominant negative effect on c-Jun N-terminal kinase signaling. J Biol Chem, 283:13132-9. (PubMed:18316368)
  115. Mansukhani A et al. (2005) Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation. J Cell Biol, 168:1065-76. (PubMed:15781477)
  116. Merte J et al. (2010) Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure. Nat Cell Biol, 12:41-6; sup pp 1-8. (PubMed:19966784)
  117. Micsenyi A et al. (2004) Beta-catenin is temporally regulated during normal liver development. Gastroenterology, 126:1134-46. (PubMed:15057752)
  118. Miranda-Carboni GA et al. (2008) A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. Genes Dev, 22:3121-34. (PubMed:19056892)
  119. Misra K et al. (2010) A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling. Dev Biol, 337:74-83. (PubMed:19850029)
  120. Miyagawa S et al. (2009) Genetic interactions of the Androgen and Wnt/{beta}-catenin Pathways for the Masculinization of External Genitalia. Mol Endocrinol, 23:871-880. (PubMed:19282366)
  121. Mucenski ML et al. (2003) beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis. J Biol Chem, 278:40231-8. (PubMed:12885771)
  122. Mucenski ML et al. (2005) Beta-catenin regulates differentiation of respiratory epithelial cells in vivo. Am J Physiol Lung Cell Mol Physiol, 289:L971-9. (PubMed:16040629)
  123. Murtaugh LC et al. (2005) Beta-catenin is essential for pancreatic acinar but not islet development. Development, 132:4663-74. (PubMed:16192304)
  124. Narducci MG et al. (2002) TCL1 participates in early embryonic development and is overexpressed in human seminomas. Proc Natl Acad Sci U S A, 99:11712-7. (PubMed:12181493)
  125. Nastasi T et al. (2004) Ozz-E3, a muscle-specific ubiquitin ligase, regulates beta-catenin degradation during myogenesis. Dev Cell, 6:269-82. (PubMed:14960280)
  126. Nguyen H et al. (2009) Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia. Nat Genet, 41:1068-75. (PubMed:19718027)
  127. Nishiyama A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell, 5:420-33. (PubMed:19796622)
  128. Nunes FD et al. (2006) Distinct subdomain organization and molecular composition of a tight junction with adherens junction features. J Cell Sci, 119:4819-27. (PubMed:17130295)
  129. Ohtani K et al. (2013) Jmjd3 controls mesodermal and cardiovascular differentiation of embryonic stem cells. Circ Res, 113:856-62. (PubMed:23856522)
  130. Oidovsambuu O et al. (2011) Adhesion protein VSIG1 is required for the proper differentiation of glandular gastric epithelia. PLoS One, 6:e25908. (PubMed:21991385)
  131. Olson LE et al. (2006) Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination. Cell, 125:593-605. (PubMed:16678101)
  132. Ormestad M et al. (2006) Foxf1 and Foxf2 control murine gut development by limiting mesenchymal Wnt signaling and promoting extracellular matrix production. Development, 133:833-43. (PubMed:16439479)
  133. Paek H et al. (2012) Increased beta-catenin activity in the anterior neural plate induces ectopic mid-hindbrain characteristics. Dev Dyn, 241:242-6. (PubMed:22102609)
  134. Pantaleon M et al. (2001) FAM deubiquitylating enzyme is essential for preimplantation mouse embryo development. Mech Dev, 109:151-60. (PubMed:11731229)
  135. Park JS et al. (2007) Wnt/{beta}-catenin signaling regulates nephron induction during mouse kidney development. Development, 134:2533-9. (PubMed:17537789)
  136. Park KS et al. (2006) APC inhibits ERK pathway activation and cellular proliferation induced by RAS. J Cell Sci, 119:819-27. (PubMed:16478791)
  137. Park YK et al. (2005) Gene expression profile analysis of mouse colon embryonic development. Genesis, 41:1-12. (PubMed:15645444)
  138. Parker JA et al. (2012) Integration of beta-Catenin, Sirtuin, and FOXO Signaling Protects from Mutant Huntingtin Toxicity. J Neurosci, 32:12630-40. (PubMed:22956852)
  139. Phng LK et al. (2009) Nrarp coordinates endothelial Notch and Wnt signaling to control vessel density in angiogenesis. Dev Cell, 16:70-82. (PubMed:19154719)
  140. Piao S et al. (2008) Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling. PLoS One, 3:e4046. (PubMed:19107203)
  141. Plante I et al. (2010) Milk secretion and ejection are impaired in the mammary gland of mice harboring a Cx43 mutant while expression and localization of tight and adherens junction proteins remain unchanged. Biol Reprod, 82:837-47. (PubMed:20089884)
  142. Pokutta S et al. (2000) Structure of the dimerization and beta-catenin-binding region of alpha-catenin Mol Cell, 5:533-43. (PubMed:10882138)
  143. Pyrgaki C et al. (2011) Grainyhead-like 2 regulates neural tube closure and adhesion molecule expression during neural fold fusion. Dev Biol, null:null. (PubMed:21377456)
  144. Rakoff-Nahoum S et al. (2007) Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science, 317:124-7. (PubMed:17615359)
  145. Ramasamy SK et al. (2007) Fgf10 dosage is critical for the amplification of epithelial cell progenitors and for the formation of multiple mesenchymal lineages during lung development. Dev Biol, 307:237-47. (PubMed:17560563)
  146. Ray S et al. (2008) Cooperative Control via Lymphoid Enhancer Factor 1/T Cell Factor 3 and Estrogen Receptor-{alpha} for Uterine Gene Regulation by Estrogen. Mol Endocrinol, 22:1125-40. (PubMed:18202148)
  147. Reya T et al. (2003) A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature, 423:409-14. (PubMed:12717450)
  148. Ridanpaa M et al. (2001) Dynamic expression and nuclear accumulation of beta-catenin during the development of hair follicle-derived structures. Mech Dev, 109:173-81. (PubMed:11731231)
  149. Rockich BE et al. (2013) Sox9 plays multiple roles in the lung epithelium during branching morphogenesis. Proc Natl Acad Sci U S A, 110:E4456-64. (PubMed:24191021)
  150. Sakanaka C et al. (1999) Functional domains of axin. Importance of the C terminus as an oligomerization domain. J Biol Chem, 274:14090-3. (PubMed:10318824)
  151. Schwitalla S et al. (2013) Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. Cell, 152:25-38. (PubMed:23273993)
  152. Sharma M et al. (2006) Membrane localization of adenomatous polyposis coli protein at cellular protrusions: targeting sequences and regulation by beta-catenin. J Biol Chem, 281:17140-9. (PubMed:16621792)
  153. Shillingford JM et al. (2002) Mouse Mammary Epithelial Cells Express the Na-K-Cl Cotransporter, NKCC1: Characterization, Localization, and Involvement in Ductal Development and Morphogenesis. Mol Endocrinol, 16:1309-21. (PubMed:12040017)
  154. Shu W et al. (2005) Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung. Dev Biol, 283:226-39. (PubMed:15907834)
  155. Si W et al. (2006) CCN1/Cyr61 is regulated by the canonical Wnt signal and plays an important role in Wnt3A-induced osteoblast differentiation of mesenchymal stem cells. Mol Cell Biol, 26:2955-64. (PubMed:16581771)
  156. Sinn HW et al. (2002) Localization of the novel Xin protein to the adherens junction complex in cardiac and skeletal muscle during development. Dev Dyn, 225:1-13. (PubMed:12203715)
  157. Smith AN et al. (2005) The duality of beta-catenin function: a requirement in lens morphogenesis and signaling suppression of lens fate in periocular ectoderm. Dev Biol, 285:477-89. (PubMed:16102745)
  158. Sokabe T et al. (2010) The TRPV4 channel contributes to intercellular junction formation in keratinocytes. J Biol Chem, 285:18749-58. (PubMed:20413591)
  159. Sorenson CM. (1999) Nuclear localization of beta-catenin and loss of apical brush border actin in cystic tubules of bcl-2 -/- mice. Am J Physiol, 276:F210-7. (PubMed:9950951)
  160. Soshnikova N et al. (2003) Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb. Genes Dev, 17:1963-8. (PubMed:12923052)
  161. Spater D et al. (2006) Wnt9a signaling is required for joint integrity and regulation of Ihh during chondrogenesis. Development, 133:3039-49. (PubMed:16818445)
  162. Stenman JM et al. (2008) Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature. Science, 322:1247-50. (PubMed:19023080)
  163. Strom A et al. (2007) Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas. Development, 134:2719-25. (PubMed:17596282)
  164. Sun Y et al. (2009) Scribble interacts with beta-catenin to localize synaptic vesicles to synapses. Mol Biol Cell, 20:3390-400. (PubMed:19458197)
  165. Takizawa S et al. (2006) Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli. Genes Cells, 11:453-64. (PubMed:16611247)
  166. Tanoue T et al. (2004) Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact. J Cell Biol, 165:517-28. (PubMed:15148305)
  167. Tebar M et al. (2001) Expression of Tcf/Lef and sFrp and localization of beta-catenin in the developing mouse lung. Mech Dev, 109:437-40. (PubMed:11731265)
  168. Teng J et al. (2005) The KIF3 motor transports N-cadherin and organizes the developing neuroepithelium. Nat Cell Biol, 7:474-82. (PubMed:15834408)
  169. Tian Y et al. (2010) Characterization and in vivo pharmacological rescue of a Wnt2-Gata6 pathway required for cardiac inflow tract development. Dev Cell, 18:275-87. (PubMed:20159597)
  170. Torban E et al. (2007) Tissue, cellular and sub-cellular localization of the Vangl2 protein during embryonic development: Effect of the Lp mutation. Gene Expr Patterns, 7:346-54. (PubMed:16962386)
  171. Tsai SY et al. (2014) Wnt/beta-catenin signaling in dermal condensates is required for hair follicle formation. Dev Biol, 385:179-88. (PubMed:24309208)
  172. Tsika RW et al. (2008) Overexpression of TEAD-1 in Transgenic Mouse Striated Muscles Produces a Slower Skeletal Muscle Contractile Phenotype. J Biol Chem, 283:36154-67. (PubMed:18978355)
  173. Tunggal JA et al. (2005) E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J, 24:1146-56. (PubMed:15775979)
  174. Ulloa F et al. (2007) Inhibitory Gli3 activity negatively regulates Wnt/beta-catenin signaling. Curr Biol, 17:545-50. (PubMed:17331723)
  175. van Es JH et al. (2005) Wnt signalling induces maturation of Paneth cells in intestinal crypts. Nat Cell Biol, 7:381-6. (PubMed:15778706)
  176. Velcich A et al. (2002) Colorectal cancer in mice genetically deficient in the mucin Muc2. Science, 295:1726-9. (PubMed:11872843)
  177. Vertino AM et al. (2005) Wnt10b deficiency promotes coexpression of myogenic and adipogenic programs in myoblasts. Mol Biol Cell, 16:2039-48. (PubMed:15673614)
  178. Villacorte M et al. (2010) Antagonistic crosstalk of Wnt/beta-catenin/Bmp signaling within the Apical Ectodermal Ridge (AER) regulates interdigit formation. Biochem Biophys Res Commun, 391:1653-7. (PubMed:20043884)
  179. Voss AK et al. (2006) C3G regulates the size of the cerebral cortex neural precursor population. EMBO J, 25:3652-63. (PubMed:16858399)
  180. Walker JL et al. (2008) Diverse roles of E-cadherin in the morphogenesis of the submandibular gland: insights into the formation of acinar and ductal structures. Dev Dyn, 237:3128-41. (PubMed:18816447)
  181. Wendeler MW et al. (2004) Ksp-cadherin is a functional cell-cell adhesion molecule related to LI-cadherin. Exp Cell Res, 294:345-55. (PubMed:15023525)
  182. Widlund HR et al. (2002) Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor. J Cell Biol, 158:1079-87. (PubMed:12235125)
  183. Wrobel CN et al. (2007) Persistent expression of stabilized beta-catenin delays maturation of radial glial cells into intermediate progenitors. Dev Biol, 309:285-97. (PubMed:17706960)
  184. Wu X et al. (2006) Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin. Genes Dev, 20:571-85. (PubMed:16510873)
  185. Xia Z et al. (2011) Functional analysis of novel phosphorylation sites of CREB-binding protein using mass spectrometry and mammalian two-hybrid assays. Proteomics, 11:3444-51. (PubMed:21751375)
  186. Xu Y et al. (2003) Deletion of beta-catenin impairs T cell development. Nat Immunol, 4:1177-82. (PubMed:14608382)
  187. Ye F et al. (2009) HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction. Nat Neurosci, 12:829-38. (PubMed:19503085)
  188. Yin Y et al. (2008) An FGF-WNT gene regulatory network controls lung mesenchyme development. Dev Biol, 319:426-36. (PubMed:18533146)
  189. Yu J et al. (2009) A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney. Development, 136:161-71. (PubMed:19060336)
  190. Zeng L et al. (1997) The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation. Cell, 90:181-92. (PubMed:9230313)
  191. Zhang Q et al. (2011) Bardet-Biedl syndrome 3 (Bbs3) knockout mouse model reveals common BBS-associated phenotypes and Bbs3 unique phenotypes. Proc Natl Acad Sci U S A, 108:20678-83. (PubMed:22139371)
  192. Zhang Y et al. (2009) Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction. Dev Cell, 17:49-61. (PubMed:19619491)
  193. Zhou W et al. (2007) Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2. Nat Genet, 39:1225-34. (PubMed:17767158)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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