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Gene Ontology Classifications

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GO curators for mouse genes have assigned the following annotations to the gene product of Cat. (This text reflects annotations as of Tuesday, May 26, 2015.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of May 23, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text for additional MGI annotations
  1. Bjorkman J et al. (2002) Pex13, the Mouse Ortholog of the Human Peroxisome Biogenesis Disorder PEX13 Gene: Gene Structure, Tissue Expression, and Localization of the Protein to Peroxisomes. Genomics, 79:162-8. (PubMed:11829486)
  2. Bonini MG et al. (2007) Immunolocalization of hypochlorite-induced, catalase-bound free radical formation in mouse hepatocytes. Free Radic Biol Med, 42:530-40. (PubMed:17275685)
  3. Brites P et al. (2003) Impaired neuronal migration and endochondral ossification in Pex7 knockout mice: a model for rhizomelic chondrodysplasia punctata. Hum Mol Genet, 12:2255-67. (PubMed:12915479)
  4. Feinstein RN et al. (1978) Carcinogenic and antitumor effects of aminotriazole on acatalasemic and normal catalase mice. J Natl Cancer Inst, 60:1113-6. (PubMed:642030)
  5. Feinstein RN et al. (1966) Acatalasemic and hypocatalasemic mouse mutants. Genetics, 53:923-33. (PubMed:5929246)
  6. Feinstein RN et al. (1968) Blood catalsase polymorphism: some immunological aspects. Science, 159:638-40. (PubMed:4975476)
  7. Felix K et al. (2003) Redox imbalance and mutagenesis in spleens of mice harboring a hypomorphic allele of Gpdx(a) encoding glucose 6-phosphate dehydrogenase. Free Radic Biol Med, 34:226-32. (PubMed:12521604)
  8. Goldfischer S et al. (1971) Hypolipidemia in a mutant strain of acatalasemic mice. Science, 173:65-6. (PubMed:5087482)
  9. Grabenbauer M et al. (2001) Detection of peroxisomal proteins and their mRNAs in serial sections of fetal and newborn mouse organs. J Histochem Cytochem, 49:155-64. (PubMed:11156684)
  10. Ho YS et al. (2004) Mice lacking catalase develop normally but show differential sensitivity to oxidant tissue injury. J Biol Chem, 279:32804-12. (PubMed:15178682)
  11. Hogenboom S et al. (2002) Absence of functional peroxisomes does not lead to deficiency of enzymes involved in cholesterol biosynthesis. J Lipid Res, 43:90-8. (PubMed:11792727)
  12. Jang BC et al. (2004) Induction of cyclooxygenase-2 in macrophages by catalase: role of NF-kappaB and PI3K signaling pathways. Biochem Biophys Res Commun, 316:398-406. (PubMed:15020231)
  13. Kaczmarek K et al. (2011) Overexpression of peroxisomal testis-specific 1 protein induces germ cell apoptosis and leads to infertility in male mice. Mol Biol Cell, 22:1766-79. (PubMed:21460186)
  14. Khan JY et al. (2003) Developmental changes in murine brain antioxidant enzymes. Pediatr Res, 54:77-82. (PubMed:12646716)
  15. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell, 115:629-40. (PubMed:14651853)
  16. Muller FL et al. (2004) Complex III releases superoxide to both sides of the inner mitochondrial membrane. J Biol Chem, 279:49064-73. (PubMed:15317809)
  17. Muppala V et al. (2000) The role of HNF-1alpha in controlling hepatic catalase activity. Mol Pharmacol, 57:93-100. (PubMed:10617683)
  18. Nenicu A et al. (2007) Peroxisomes in human and mouse testis: differential expression of peroxisomal proteins in germ cells and distinct somatic cell types of the testis. Biol Reprod, 77:1060-72. (PubMed:17881773)
  19. Nilakantan V et al. (1998) Liver-specific catalase expression in transgenic mice inhibits NF-kappaB activation and DNA synthesis induced by the peroxisome proliferator ciprofibrate. Carcinogenesis, 19:631-7. (PubMed:9600348)
  20. Zhen LX et al. (1993) Inhibitory effect of alpha-tocopherol on methemoglobin formation by nitric oxide in normal and acatalasemic mouse hemolysates. Physiol Chem Phys Med NMR, 25:253-60. (PubMed:8153151)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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