Automated description from the Alliance of Genome Resources (Release 4.0)
Predicted to enable C5L2 anaphylatoxin chemotactic receptor binding activity and lipid binding activity. Involved in several processes, including complement-mediated synapse pruning; nervous system development; and positive regulation of endocytosis. Acts upstream of or within several processes, including complement-dependent cytotoxicity; oviduct epithelium development; and positive regulation of immune response. Located in cell surface and extracellular space. Part of protein-containing complex. Is expressed in several structures, including adipose tissue; cerebral cortex; extraembryonic component; hemolymphoid system; and liver. Used to study complement component 3 deficiency. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; complement deficiency (multiple); macular degeneration (multiple); paroxysmal nocturnal hemoglobinuria; and sickle cell anemia. Orthologous to human C3 (complement C3).