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Gene Ontology Classifications
Symbol
Name
ID
Braf
Braf transforming gene
MGI:88190

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Braf. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Andreadi C et al. (2012) The intermediate-activity L597VBRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway. Genes Dev, 26:1945-58. (PubMed:22892241)
  2. Camarero G et al. (2006) Cortical migration defects in mice expressing A-RAF from the B-RAF locus. Mol Cell Biol, 26:7103-15. (PubMed:16980614)
  3. Chen AP et al. (2006) Forebrain-specific knockout of B-raf kinase leads to deficits in hippocampal long-term potentiation, learning, and memory. J Neurosci Res, 83:28-38. (PubMed:16342120)
  4. Couto JP et al. (2012) STAT3 negatively regulates thyroid tumorigenesis. Proc Natl Acad Sci U S A, 109:E2361-70. (PubMed:22891351)
  5. Dillon TJ et al. (2013) B-Raf is required for positive selection and survival of DP cells, but not for negative selection of SP cells. Int Immunol, 25:259-69. (PubMed:23334952)
  6. Gotz R et al. (2005) Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells. Nat Neurosci, 8:1169-78. (PubMed:16116448)
  7. Heidorn SJ et al. (2010) Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF. Cell, 140:209-21. (PubMed:20141835)
  8. Hong SW et al. (2012) Ring finger protein 149 is an E3 ubiquitin ligase active on wild-type v-Raf murine sarcoma viral oncogene homolog B1 (BRAF). J Biol Chem, 287:24017-25. (PubMed:22628551)
  9. Kamata T et al. (2005) A critical function for B-Raf at multiple stages of myelopoiesis. Blood, 106:833-40. (PubMed:15784729)
  10. Packer LM et al. (2011) Nilotinib and MEK inhibitors induce synthetic lethality through paradoxical activation of RAF in drug-resistant chronic myeloid leukemia. Cancer Cell, 20:715-27. (PubMed:22169110)
  11. Pritchard CA et al. (2004) B-Raf acts via the ROCKII/LIMK/cofilin pathway to maintain actin stress fibers in fibroblasts. Mol Cell Biol, 24:5937-52. (PubMed:15199148)
  12. Ren JG et al. (2007) IQGAP1 modulates activation of B-Raf. Proc Natl Acad Sci U S A, 104:10465-9. (PubMed:17563371)
  13. Subramanian J et al. (2013) Rap1 signaling prevents L-type calcium channel-dependent neurotransmitter release. J Neurosci, 33:7245-52. (PubMed:23616533)
  14. Valluet A et al. (2012) B-Raf and C-Raf are required for melanocyte stem cell self-maintenance. Cell Rep, 2:774-80. (PubMed:23022482)
  15. Wojnowski L et al. (2000) Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis. Mech Dev, 91:97-104. (PubMed:10704835)
  16. Wojnowski L et al. (1997) Endothelial apoptosis in Braf-deficient mice [see comments] Nat Genet, 16:293-7. (PubMed:9207797)
  17. Xie Y et al. (2005) Six post-implantation lethal knockouts of genes for lipophilic MAPK pathway proteins are expressed in preimplantation mouse embryos and trophoblast stem cells. Mol Reprod Dev, 71:1-11. (PubMed:15736129)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory