Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Bmp4. (This text reflects annotations as of Thursday, January 16, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Bmp4
  • participates in the following biological processes:
    • blood vessel development ^[56]
    • BMP signaling pathway ^{[32, 71]}
    • BMP signaling pathway involved in ureter morphogenesis ^[8]
    • bone development ^[62]
    • bud elongation involved in lung branching ^[58]
    • cell fate commitment ^[19]
    • cellular response to growth factor stimulus ^[5]
    • cranial suture morphogenesis ^[30]
    • dorsal/ventral neural tube patterning ^[22]
    • epithelial-mesenchymal cell signaling ^[67]
    • epithelium development ^[11]
    • erythrocyte differentiation ^[34]
    • hematopoietic progenitor cell differentiation ^[26]
    • mesoderm formation ^{[26, 33]}
    • mesodermal cell differentiation ^[26]
    • metanephros development ^[46]
    • negative regulation of branching involved in ureteric bud morphogenesis ^[35]
    • negative regulation of chondrocyte differentiation ^[73]
    • negative regulation of gene expression ^[41]
    • negative regulation of prostatic bud formation ^[68]
    • negative regulation of transcription from RNA polymerase II promoter ^[43]
    • neural tube closure ^[45]
    • neuron fate commitment ^[20]
    • odontogenesis of dentin-containing tooth ^{[28, 69]}
    • osteoblast differentiation ^[24]
    • positive regulation of BMP signaling pathway ^[7]
    • positive regulation of cell differentiation ^[69]
    • positive regulation of endothelial cell differentiation ^[61]
    • positive regulation of endothelial cell proliferation ^[61]
    • positive regulation of ERK1 and ERK2 cascade ^[37]
    • positive regulation of neuron differentiation ^[36]
    • positive regulation of ossification ^[62]
    • positive regulation of transcription from RNA polymerase II promoter ^{[6, 10, 11, 21, 30, 37, 64, 67]}
    • regulation of cartilage development ^[27]
    • regulation of gene expression ^[76]
    • regulation of smooth muscle cell differentiation ^[2]
    • regulation of smooth muscle cell proliferation ^[42]
    • skeletal system development ^[77]
    • SMAD protein signal transduction ^[59]
    • smooth muscle cell differentiation ^[23]
    • telencephalon regionalization ^[12]
    • ureteric bud development ^[46]
  • performs the following molecular functions:
    • heparin binding ^[24]
  • is located in the following cellular components:
    • extracellular region ^[62]
    • extracellular space ^[73]
• The gene product of Bmp4 has been shown to bind to the gene products of Bmper, Chrdl2, Hfe2, Htra1, Htra3, Rgma. ^{[3, 4, 24, 32, 48, 50, 53, 65]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Bmp4
  • participates in the following biological processes:
    • angiogenesis ^[40]
    • BMP signaling pathway involved in renal system segmentation ^[8]
    • branching involved in prostate gland morphogenesis ^[31]
    • camera-type eye development ^[16]
    • camera-type eye morphogenesis ^[16]
    • chondrocyte differentiation ^[7]
    • deltoid tuberosity development ^[7]
    • embryonic cranial skeleton morphogenesis ^[16]
    • embryonic limb morphogenesis ^[29]
    • embryonic morphogenesis ^[39]
    • embryonic skeletal joint morphogenesis ^[29]
    • embryonic skeletal system development ^[60]
    • embryonic skeletal system morphogenesis ^[60]
    • endochondral ossification ^[7]
    • forebrain development ^[16]
    • germ cell development ^[15]
    • glomerular capillary formation ^[66]
    • heart development ^{[25, 40]}
    • kidney development ^[16]
    • lens induction in camera-type eye ^[18]
    • lung development ^[17]
    • mammary gland formation ^[13]
    • mesenchymal cell differentiation involved in kidney development ^[8]
    • mesenchymal cell differentiation involved in renal system development ^[8]
    • mesodermal cell fate determination ^[70]
    • metanephric collecting duct development ^[8]
    • metanephros development ^[46]
    • negative regulation of apoptotic process ^[46]
    • negative regulation of epithelial cell proliferation ^[31]
    • negative regulation of prostatic bud formation ^[31]
    • neuron fate commitment ^[20]
    • organ induction ^[63]
    • pituitary gland development ^[63]
    • positive regulation of branching involved in lung morphogenesis ^[78]
    • positive regulation of cell proliferation ^[37]
    • positive regulation of gene expression ^[72]
    • positive regulation of protein phosphorylation ^[37]
    • positive regulation of transcription from RNA polymerase II promoter ^[37]
    • post-embryonic development ^[16]
    • prostate gland morphogenesis ^{[16, 31]}
    • regulation of branching involved in prostate gland morphogenesis ^[1]
    • regulation of gene expression ^[9]
    • regulation of morphogenesis of a branching structure ^[31]
    • renal system process ^[16]
    • skeletal system development ^[38]
    • smooth muscle tissue development ^[46]
    • specification of organ position ^[13]
    • tendon cell differentiation ^[7]
    • trachea formation ^[37]
    • ureter epithelial cell differentiation ^[8]
    • ureter smooth muscle cell differentiation ^[8]
    • ureteric bud development ^[46]
    • vasculature development ^[2]
• Researchers have inferred, based on genetic interactions, that the gene product of Bmp4
  • participates in the following biological processes:
    • anatomical structure formation involved in morphogenesis based on interactions with Nog ^[57]
    • anterior/posterior axis specification based on interactions with Gpc3 ^[55]
    • BMP signaling pathway based on interactions with Rgma ^[3]
    • branching involved in ureteric bud morphogenesis based on interactions with Grem1 ^[44]
    • camera-type eye development based on interactions with Twsg1 ^[74]
    • embryonic digit morphogenesis based on interactions with Alx4, Gli3 ^[16]
    • embryonic hindlimb morphogenesis based on interactions with Gpc3 ^[55]
    • embryonic limb morphogenesis based on interactions with Bmp7 ^[29]
    • embryonic skeletal joint morphogenesis based on interactions with Bmp7 ^[29]
    • forebrain development based on interactions with Twsg1 ^[74]
    • inner ear receptor cell differentiation based on interactions with Fgfr3 ^[49]
    • kidney development based on interactions with Bmp7 ^[54]
    • negative regulation of cell proliferation based on interactions with Nog ^[14]
    • odontogenesis of dentin-containing tooth based on interactions with Sostdc1 ^[28]
    • positive regulation of transcription from RNA polymerase II promoter based on interactions with Msx1 ^{[11, 75]}
    • regulation of cell differentiation based on interactions with Fst ^[69]
    • regulation of odontogenesis of dentin-containing tooth based on interactions with Bmp2, Fgf8 ^[51]
    • regulation of smooth muscle cell differentiation based on interactions with Foxf1 ^[2]
    • renal system development based on interactions with Six1 ^[52]
    • telencephalon regionalization based on interactions with Lhx2 ^[47]
    • tissue development based on interactions with Twsg1 ^[74]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Bmp4:
  • participates in the following biological processes:
    • activation of MAPKK activity
    • blood vessel endothelial cell proliferation involved in sprouting angiogenesis
    • BMP signaling pathway
    • BMP signaling pathway involved in heart induction
    • BMP signaling pathway involved in nephric duct formation
    • branching involved in ureteric bud morphogenesis
    • branching morphogenesis of an epithelial tube
    • bronchus development
    • bud dilation involved in lung branching
    • cellular response to dexamethasone stimulus
    • common-partner SMAD protein phosphorylation
    • epithelial cell proliferation involved in lung morphogenesis
    • epithelial tube branching involved in lung morphogenesis
    • hematopoietic progenitor cell differentiation
    • intermediate mesodermal cell differentiation
    • kidney development
    • lung alveolus development
    • lung morphogenesis
    • lymphoid progenitor cell differentiation
    • macrophage differentiation
    • mesenchymal to epithelial transition involved in metanephros morphogenesis
    • monocyte differentiation
    • negative regulation of apoptotic process
    • negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway
    • negative regulation of branching involved in ureteric bud morphogenesis
    • negative regulation of cell cycle
    • negative regulation of cell death
    • negative regulation of cell proliferation
    • negative regulation of cell proliferation involved in heart morphogenesis
    • negative regulation of glomerular mesangial cell proliferation
    • negative regulation of glomerulus development
    • negative regulation of immature T cell proliferation in thymus
    • negative regulation of MAP kinase activity
    • negative regulation of mesenchymal cell proliferation involved in ureter development
    • negative regulation of metanephric comma-shaped body morphogenesis
    • negative regulation of metanephric S-shaped body morphogenesis
    • negative regulation of mitosis
    • negative regulation of myoblast differentiation
    • negative regulation of oligodendrocyte differentiation
    • negative regulation of phosphorylation
    • negative regulation of striated muscle tissue development
    • negative regulation of T cell differentiation in thymus
    • negative regulation of thymocyte apoptotic process
    • negative regulation of transcription from RNA polymerase II promoter
    • negative regulation of transcription, DNA-templated
    • odontogenesis
    • osteoblast differentiation
    • ovarian follicle development
    • positive chemotaxis
    • positive regulation of apoptotic process
    • positive regulation of bone mineralization
    • positive regulation of branching involved in ureteric bud morphogenesis
    • positive regulation of cardiac muscle fiber development
    • positive regulation of cartilage development
    • positive regulation of cell death
    • positive regulation of cell proliferation
    • positive regulation of collagen biosynthetic process
    • positive regulation of DNA-dependent DNA replication
    • positive regulation of endothelial cell migration
    • positive regulation of endothelial cell proliferation
    • positive regulation of epithelial cell proliferation
    • positive regulation of kidney development
    • positive regulation of ossification
    • positive regulation of osteoblast differentiation
    • positive regulation of pathway-restricted SMAD protein phosphorylation
    • positive regulation of protein binding
    • positive regulation of protein phosphorylation
    • positive regulation of SMAD protein import into nucleus
    • positive regulation of smooth muscle cell proliferation
    • positive regulation of transcription from RNA polymerase II promoter
    • positive regulation of transcription, DNA-templated
    • post-embryonic development
    • protein localization to nucleus
    • pulmonary artery endothelial tube morphogenesis
    • regulation of cell differentiation
    • regulation of pathway-restricted SMAD protein phosphorylation
    • secondary heart field specification
    • SMAD protein signal transduction
    • specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway
    • steroid hormone mediated signaling pathway
    • telencephalon development
    • trachea development
    • type B pancreatic cell development
    • ureteric bud development
  • performs the following molecular functions:
    • BMP receptor binding
    • chemoattractant activity
    • cytokine activity
    • growth factor activity
    • protein homodimerization activity
  • is located in the following cellular components:
    • cytoplasm
    • extracellular space
    • membrane-bounded vesicle

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Summary text based on GO annotations supported by structural data

• Bmp4 encodes a protein or proteins that contain the following InterPro domains: Transforming growth factor beta, conserved site, Transforming growth factor-beta, C-terminal, Transforming growth factor-beta, N-terminal, Transforming growth factor-beta-related, indicating that the gene product:
  • participates in the following biological processes:
    • growth

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Bmp4 indicates that it:
  • participates in the following biological processes:
    • cartilage development
    • cell differentiation
    • multicellular organismal development
    • ossification
  • is located in the following cellular components:
    • proteinaceous extracellular matrix

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References

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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