Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Bmp4. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Bmp4
  • participates in the following biological processes:
    • blood vessel development ^[56]
    • BMP signaling pathway ^{[32, 71]}
    • BMP signaling pathway involved in ureter morphogenesis ^[8]
    • bone development ^[62]
    • bud elongation involved in lung branching ^[58]
    • cell fate commitment ^[19]
    • cellular response to growth factor stimulus ^[5]
    • cranial suture morphogenesis ^[30]
    • dorsal/ventral neural tube patterning ^[22]
    • epithelial-mesenchymal cell signaling ^[67]
    • epithelium development ^[11]
    • erythrocyte differentiation ^[34]
    • hematopoietic progenitor cell differentiation ^[26]
    • mesoderm formation ^{[26, 33]}
    • mesodermal cell differentiation ^[26]
    • metanephros development ^[46]
    • negative regulation of branching involved in ureteric bud morphogenesis ^[35]
    • negative regulation of chondrocyte differentiation ^[73]
    • negative regulation of gene expression ^[41]
    • negative regulation of prostatic bud formation ^[68]
    • negative regulation of transcription from RNA polymerase II promoter ^[43]
    • neural tube closure ^[45]
    • neuron fate commitment ^[20]
    • odontogenesis of dentin-containing tooth ^{[28, 69]}
    • osteoblast differentiation ^[24]
    • positive regulation of BMP signaling pathway ^[7]
    • positive regulation of cell differentiation ^[69]
    • positive regulation of endothelial cell differentiation ^[61]
    • positive regulation of endothelial cell proliferation ^[61]
    • positive regulation of ERK1 and ERK2 cascade ^[37]
    • positive regulation of neuron differentiation ^[36]
    • positive regulation of ossification ^[62]
    • positive regulation of transcription from RNA polymerase II promoter ^{[6, 10, 11, 21, 30, 37, 64, 67]}
    • regulation of cartilage development ^[27]
    • regulation of gene expression ^[76]
    • regulation of smooth muscle cell differentiation ^[2]
    • regulation of smooth muscle cell proliferation ^[42]
    • skeletal system development ^[77]
    • SMAD protein signal transduction ^[59]
    • smooth muscle cell differentiation ^[23]
    • telencephalon regionalization ^[12]
    • ureteric bud development ^[46]
  • performs the following molecular functions:
    • heparin binding ^[24]
  • is located in the following cellular components:
    • extracellular region ^[62]
    • extracellular space ^[73]
• The gene product of Bmp4 has been shown to bind to the gene products of Bmper, Chrdl2, Hfe2, Htra1, Htra3, Rgma. ^{[3, 4, 24, 32, 48, 50, 53, 65]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Bmp4
  • participates in the following biological processes:
    • angiogenesis ^[40]
    • BMP signaling pathway involved in renal system segmentation ^[8]
    • branching involved in prostate gland morphogenesis ^[31]
    • camera-type eye development ^[16]
    • camera-type eye morphogenesis ^[16]
    • chondrocyte differentiation ^[7]
    • deltoid tuberosity development ^[7]
    • embryonic cranial skeleton morphogenesis ^[16]
    • embryonic limb morphogenesis ^[29]
    • embryonic morphogenesis ^[39]
    • embryonic skeletal joint morphogenesis ^[29]
    • embryonic skeletal system development ^[60]
    • embryonic skeletal system morphogenesis ^[60]
    • endochondral ossification ^[7]
    • forebrain development ^[16]
    • germ cell development ^[15]
    • glomerular capillary formation ^[66]
    • heart development ^{[25, 40]}
    • kidney development ^[16]
    • lens induction in camera-type eye ^[18]
    • lung development ^[17]
    • mammary gland formation ^[13]
    • mesenchymal cell differentiation involved in kidney development ^[8]
    • mesenchymal cell differentiation involved in renal system development ^[8]
    • mesodermal cell fate determination ^[70]
    • metanephric collecting duct development ^[8]
    • metanephros development ^[46]
    • negative regulation of apoptotic process ^[46]
    • negative regulation of epithelial cell proliferation ^[31]
    • negative regulation of prostatic bud formation ^[31]
    • neuron fate commitment ^[20]
    • organ induction ^[63]
    • pituitary gland development ^[63]
    • positive regulation of branching involved in lung morphogenesis ^[78]
    • positive regulation of cell proliferation ^[37]
    • positive regulation of gene expression ^[72]
    • positive regulation of protein phosphorylation ^[37]
    • positive regulation of transcription from RNA polymerase II promoter ^[37]
    • post-embryonic development ^[16]
    • prostate gland morphogenesis ^{[16, 31]}
    • regulation of branching involved in prostate gland morphogenesis ^[1]
    • regulation of gene expression ^[9]
    • regulation of morphogenesis of a branching structure ^[31]
    • renal system process ^[16]
    • skeletal system development ^[38]
    • smooth muscle tissue development ^[46]
    • specification of organ position ^[13]
    • tendon cell differentiation ^[7]
    • trachea formation ^[37]
    • ureter epithelial cell differentiation ^[8]
    • ureter smooth muscle cell differentiation ^[8]
    • ureteric bud development ^[46]
    • vasculature development ^[2]
• Researchers have inferred, based on genetic interactions, that the gene product of Bmp4
  • participates in the following biological processes:
    • anatomical structure formation involved in morphogenesis based on interactions with Nog ^[57]
    • anterior/posterior axis specification based on interactions with Gpc3 ^[55]
    • BMP signaling pathway based on interactions with Rgma ^[3]
    • branching involved in ureteric bud morphogenesis based on interactions with Grem1 ^[44]
    • camera-type eye development based on interactions with Twsg1 ^[74]
    • embryonic digit morphogenesis based on interactions with Alx4, Gli3 ^[16]
    • embryonic hindlimb morphogenesis based on interactions with Gpc3 ^[55]
    • embryonic limb morphogenesis based on interactions with Bmp7 ^[29]
    • embryonic skeletal joint morphogenesis based on interactions with Bmp7 ^[29]
    • forebrain development based on interactions with Twsg1 ^[74]
    • inner ear receptor cell differentiation based on interactions with Fgfr3 ^[49]
    • kidney development based on interactions with Bmp7 ^[54]
    • negative regulation of cell proliferation based on interactions with Nog ^[14]
    • odontogenesis of dentin-containing tooth based on interactions with Sostdc1 ^[28]
    • positive regulation of transcription from RNA polymerase II promoter based on interactions with Msx1 ^{[11, 75]}
    • regulation of cell differentiation based on interactions with Fst ^[69]
    • regulation of odontogenesis of dentin-containing tooth based on interactions with Bmp2, Fgf8 ^[51]
    • regulation of smooth muscle cell differentiation based on interactions with Foxf1 ^[2]
    • renal system development based on interactions with Six1 ^[52]
    • telencephalon regionalization based on interactions with Lhx2 ^[47]
    • tissue development based on interactions with Twsg1 ^[74]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Bmp4:
  • participates in the following biological processes:
    • activation of MAPKK activity
    • blood vessel endothelial cell proliferation involved in sprouting angiogenesis
    • BMP signaling pathway
    • BMP signaling pathway involved in heart induction
    • BMP signaling pathway involved in nephric duct formation
    • branching involved in ureteric bud morphogenesis
    • branching morphogenesis of a tube
    • bronchus development
    • bud dilation involved in lung branching
    • cellular response to dexamethasone stimulus
    • epithelial cell proliferation involved in lung morphogenesis
    • epithelial tube branching involved in lung morphogenesis
    • hematopoietic progenitor cell differentiation
    • intermediate mesodermal cell differentiation
    • kidney development
    • lung alveolus development
    • lung morphogenesis
    • lymphoid progenitor cell differentiation
    • macrophage differentiation
    • mesenchymal to epithelial transition involved in metanephros morphogenesis
    • monocyte differentiation
    • negative regulation of apoptotic process
    • negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway
    • negative regulation of branching involved in ureteric bud morphogenesis
    • negative regulation of cell cycle
    • negative regulation of cell death
    • negative regulation of cell proliferation
    • negative regulation of cell proliferation involved in heart morphogenesis
    • negative regulation of glomerular mesangial cell proliferation
    • negative regulation of glomerulus development
    • negative regulation of immature T cell proliferation in thymus
    • negative regulation of MAP kinase activity
    • negative regulation of mesenchymal cell proliferation involved in ureter development
    • negative regulation of metanephric comma-shaped body morphogenesis
    • negative regulation of metanephric S-shaped body morphogenesis
    • negative regulation of mitosis
    • negative regulation of myoblast differentiation
    • negative regulation of oligodendrocyte differentiation
    • negative regulation of phosphorylation
    • negative regulation of striated muscle tissue development
    • negative regulation of T cell differentiation in thymus
    • negative regulation of thymocyte apoptotic process
    • negative regulation of transcription from RNA polymerase II promoter
    • negative regulation of transcription, DNA-dependent
    • odontogenesis
    • osteoblast differentiation
    • ovarian follicle development
    • positive chemotaxis
    • positive regulation of apoptotic process
    • positive regulation of bone mineralization
    • positive regulation of branching involved in ureteric bud morphogenesis
    • positive regulation of cardiac muscle fiber development
    • positive regulation of cartilage development
    • positive regulation of cell death
    • positive regulation of cell proliferation
    • positive regulation of collagen biosynthetic process
    • positive regulation of DNA-dependent DNA replication
    • positive regulation of endothelial cell migration
    • positive regulation of endothelial cell proliferation
    • positive regulation of epithelial cell proliferation
    • positive regulation of kidney development
    • positive regulation of ossification
    • positive regulation of osteoblast differentiation
    • positive regulation of pathway-restricted SMAD protein phosphorylation
    • positive regulation of protein phosphorylation
    • positive regulation of SMAD protein import into nucleus
    • positive regulation of smooth muscle cell proliferation
    • positive regulation of transcription from RNA polymerase II promoter
    • positive regulation of transcription, DNA-dependent
    • post-embryonic development
    • protein localization to nucleus
    • pulmonary artery endothelial tube morphogenesis
    • regulation of cell differentiation
    • regulation of pathway-restricted SMAD protein phosphorylation
    • secondary heart field specification
    • SMAD protein signal transduction
    • specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway
    • steroid hormone mediated signaling pathway
    • telencephalon development
    • trachea development
    • type B pancreatic cell development
    • ureteric bud development
  • performs the following molecular functions:
    • BMP receptor binding
    • chemoattractant activity
    • cytokine activity
    • growth factor activity
    • protein homodimerization activity
  • is located in the following cellular components:
    • cytoplasm
    • extracellular space
    • membrane-bounded vesicle

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Summary text based on GO annotations supported by structural data

• Bmp4 encodes a protein or proteins that contain the following InterPro domains: Transforming growth factor beta, conserved site, Transforming growth factor-beta, C-terminal, Transforming growth factor-beta, N-terminal, Transforming growth factor-beta-related, indicating that the gene product:
  • participates in the following biological processes:
    • growth

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Bmp4 indicates that it:
  • participates in the following biological processes:
    • cartilage development
    • cell differentiation
    • multicellular organismal development
    • ossification
  • is located in the following cellular components:
    • proteinaceous extracellular matrix

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References

1. Almahbobi G et al. (2005) Computer-based detection of neonatal changes to branching morphogenesis reveals different mechanisms of and predicts prostate enlargement in mice haplo-insufficient for bone morphogenetic protein 4. J Pathol, 206:52-61. (PubMed:15772937)
2. Astorga J et al. (2007) Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4. Development, 134:3753-61. (PubMed:17881493)
3. Babitt JL et al. (2005) Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor. J Biol Chem, 280:29820-7. (PubMed:15975920)
4. Babitt JL et al. (2006) Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet, 38:531-9. (PubMed:16604073)
5. Begue-Kirn C et al. (1994) Comparative analysis of TGF beta s, BMPs, IGF1, msxs, fibronectin, osteonectin and bone sialoprotein gene expression during normal and in vitro-induced odontoblast differentiation. Int J Dev Biol, 38:405-20. (PubMed:7848824)
6. Biben C et al. (1998) Murine cerberus homologue mCer-1: a candidate anterior patterning molecule. Dev Biol, 194:135-51. (PubMed:9501024)
7. Blitz E et al. (2009) Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction. Dev Cell, 17:861-73. (PubMed:20059955)
8. Brenner-Anantharam A et al. (2007) Tailbud-derived mesenchyme promotes urinary tract segmentation via BMP4 signaling. Development, 134:1967-75. (PubMed:17442697)
9. Busygina TV et al. (2001) [Effect of genotype and social stress on cAMP- and substrate-dependent mechanisms of regulating hormonal function of testis in mice] Genetika, 37:649-56. (PubMed:11436557)
10. Caubit X et al. (2008) Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4. Development, 135:3301-10. (PubMed:18776146)
11. Chen Y et al. (1996) Msx1 controls inductive signaling in mammalian tooth morphogenesis. Development, 122:3035-44. (PubMed:8898217)
12. Cheng X et al. (2006) Central roles of the roof plate in telencephalic development and holoprosencephaly. J Neurosci, 26:7640-9. (PubMed:16855091)
13. Cho KW et al. (2006) Molecular interactions between Tbx3 and Bmp4 and a model for dorsoventral positioning of mammary gland development. Proc Natl Acad Sci U S A, 103:16788-93. (PubMed:17071745)
14. Cook C et al. (2007) Noggin is required for normal lobe patterning and ductal budding in the mouse prostate. Dev Biol, 312:217-30. (PubMed:18028901)
15. de Sousa Lopes SM et al. (2004) BMP signaling mediated by ALK2 in the visceral endoderm is necessary for the generation of primordial germ cells in the mouse embryo. Genes Dev, 18:1838-49. (PubMed:15289457)
16. Dunn NR et al. (1997) Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4. Dev Biol, 188:235-47. (PubMed:9268572)
17. Eblaghie MC et al. (2006) Evidence that autocrine signaling through Bmpr1a regulates the proliferation, survival and morphogenetic behavior of distal lung epithelial cells. Dev Biol, 291:67-82. (PubMed:16414041)
18. Furuta Y et al. (1998) BMP4 is essential for lens induction in the mouse embryo. Genes Dev, 12:3764-75. (PubMed:9851982)
19. Hager-Theodorides AL et al. (2002) Bone morphogenetic protein 2/4 signaling regulates early thymocyte differentiation. J Immunol, 169:5496-504. (PubMed:12421925)
20. Hodge LK et al. (2007) Retrograde BMP signaling regulates trigeminal sensory neuron identities and the formation of precise face maps. Neuron, 55:572-86. (PubMed:17698011)
21. Hollnagel A et al. (1999) Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells. J Biol Chem, 274:19838-45. (PubMed:10391928)
22. Hu Q et al. (2004) Restriction of BMP4 activity domains in the developing neural tube of the mouse embryo. EMBO Rep, 5:734-9. (PubMed:15218525)
23. Itaranta P et al. (2006) Wnt-4 signaling is involved in the control of smooth muscle cell fate via Bmp-4 in the medullary stroma of the developing kidney. Dev Biol, 293:473-83. (PubMed:16546160)
24. Jasuja R et al. (2004) Cell-surface heparan sulfate proteoglycans potentiate chordin antagonism of bone morphogenetic protein signaling and are necessary for cellular uptake of chordin. J Biol Chem, 279:51289-97. (PubMed:15381701)
25. Jiao K et al. (2003) An essential role of Bmp4 in the atrioventricular septation of the mouse heart. Genes Dev, 17:2362-7. (PubMed:12975322)
26. Johansson BM et al. (1995) Evidence for involvement of activin A and bone morphogenetic protein 4 in mammalian mesoderm and hematopoietic development. Mol Cell Biol, 15:141-51. (PubMed:7799920)
27. Karamboulas K et al. (2010) Regulation of BMP-dependent chondrogenesis in early limb mesenchyme by TGFbeta signals. J Cell Sci, 123:2068-76. (PubMed:20501701)
28. Kassai Y et al. (2005) Regulation of mammalian tooth cusp patterning by ectodin. Science, 309:2067-70. (PubMed:16179481)
29. Katagiri T et al. (1998) Skeletal abnormalities in doubly heterozygous Bmp4 and Bmp7 mice. Dev Genet, 22:340-8. (PubMed:9664686)
30. Kim HJ et al. (1998) FGF-, BMP- and Shh-mediated signalling pathways in the regulation of cranial suture morphogenesis and calvarial bone development. Development, 125:1241-51. (PubMed:9477322)
31. Lamm ML et al. (2001) Mesenchymal factor bone morphogenetic protein 4 restricts ductal budding and branching morphogenesis in the developing prostate. Dev Biol, 232:301-14. (PubMed:11401393)
32. Laurikkala J et al. (2003) Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot. Dev Biol, 264:91-105. (PubMed:14623234)
33. Lee D et al. (2008) ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell, 2:497-507. (PubMed:18462699)
34. Lenox LE et al. (2005) BMP4 and Madh5 regulate the erythroid response to acute anemia. Blood, 105:2741-8. (PubMed:15591122)
35. Levinson RS et al. (2005) Foxd1-dependent signals control cellularity in the renal capsule, a structure required for normal renal development. Development, 132:529-39. (PubMed:15634693)
36. Li W et al. (1998) Neuronal differentiation of precursors in the neocortical ventricular zone is triggered by BMP. J Neurosci, 18:8853-62. (PubMed:9786991)
37. Li Y et al. (2008) Bmp4 is required for tracheal formation: a novel mouse model for tracheal agenesis. Dev Biol, 322:145-55. (PubMed:18692041)
38. Liu W et al. (2005) Threshold-specific requirements for Bmp4 in mandibular development. Dev Biol, 283:282-93. (PubMed:15936012)
39. Liu W et al. (2005) Distinct functions for Bmp signaling in lip and palate fusion in mice. Development, 132:1453-61. (PubMed:15716346)
40. Liu W et al. (2004) Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling. Proc Natl Acad Sci U S A, 101:4489-94. (PubMed:15070745)
41. Mahlapuu M et al. (2001) Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations. Development, 128:2397-406. (PubMed:11493558)
42. Mailleux AA et al. (2005) Fgf10 expression identifies parabronchial smooth muscle cell progenitors and is required for their entry into the smooth muscle cell lineage. Development, 132:2157-66. (PubMed:15800000)
43. McMahon JA et al. (1998) Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Genes Dev, 12:1438-52. (PubMed:9585504)
44. Michos O et al. (2007) Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis. Development, 134:2397-405. (PubMed:17522159)
45. Misra K et al. (2010) A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling. Dev Biol, 337:74-83. (PubMed:19850029)
46. Miyazaki Y et al. (2003) Evidence that bone morphogenetic protein 4 has multiple biological functions during kidney and urinary tract development. Kidney Int, 63:835-44. (PubMed:12631064)
47. Monuki ES et al. (2001) Patterning of the dorsal telencephalon and cerebral cortex by a roof plate-lhx2 pathway. Neuron, 32:591-604. (PubMed:11719201)
48. Moser M et al. (2003) BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation. Mol Cell Biol, 23:5664-79. (PubMed:12897139)
49. Murashima-Suginami A et al. (2007) Rudiment incisors survive and erupt as supernumerary teeth as a result of USAG-1 abrogation. Biochem Biophys Res Commun, 359:549-55. (PubMed:17555714)
50. Nakayama N et al. (2004) A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage. Development, 131:229-40. (PubMed:14660436)
51. Neubuser A et al. (1997) Antagonistic interactions between FGF and BMP signaling pathways: a mechanism for positioning the sites of tooth formation. Cell, 90:247-55. (PubMed:9244299)
52. Nie X et al. (2011) Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis. Dev Biol, 352:141-51. (PubMed:21281623)
53. Oka C et al. (2004) HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteins. Development, 131:1041-53. (PubMed:14973287)
54. Oxburgh L et al. (2005) BMP4 substitutes for loss of BMP7 during kidney development. Dev Biol, 286:637-46. (PubMed:16154126)
55. Paine-Saunders S et al. (2000) glypican-3 controls cellular responses to Bmp4 in limb patterning and skeletal development. Dev Biol, 225:179-87. (PubMed:10964473)
56. Phelan JP. (1992) Genetic variability and rodent models of human aging. Exp Gerontol, 27:147-59. (PubMed:1521591)
57. Que J et al. (2006) Morphogenesis of the trachea and esophagus: current players and new roles for noggin and Bmps. Differentiation, 74:422-37. (PubMed:16916379)
58. Rajagopal J et al. (2008) Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme. Development, 135:1625-34. (PubMed:18367557)
59. Sirard C et al. (1998) The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev, 12:107-19. (PubMed:9420335)
60. Stottmann RW et al. (2006) The BMP antagonist Noggin promotes cranial and spinal neurulation by distinct mechanisms. Dev Biol, 295:647-63. (PubMed:16712836)
61. Suzuki Y et al. (2010) BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo. J Cell Sci, 123:1684-92. (PubMed:20406889)
62. Takaoka K et al. (1993) Gene cloning and expression of a bone morphogenetic protein derived from a murine osteosarcoma. Clin Orthop, 294:344-52. (PubMed:8358941)
63. Takuma N et al. (1998) Formation of Rathke's pouch requires dual induction from the diencephalon. Development, 125:4835-40. (PubMed:9806931)
64. Thesleff I et al. (1996) Molecular mechanisms of cell and tissue interactions during early tooth development. Anat Rec, 245:151-61. (PubMed:8769660)
65. Tocharus J et al. (2004) Developmentally regulated expression of mouse HtrA3 and its role as an inhibitor of TGF-beta signaling. Dev Growth Differ, 46:257-74. (PubMed:15206957)
66. Ueda H et al. (2008) Bmp in podocytes is essential for normal glomerular capillary formation. J Am Soc Nephrol, 19:685-94. (PubMed:18272846)
67. Vainio S et al. (1993) Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development. Cell, 75:45-58. (PubMed:8104708)
68. Vezina CM et al. (2008) Retinoic acid induces prostatic bud formation. Dev Dyn, 237:1321-33. (PubMed:18393306)
69. Wang XP et al. (2004) Follistatin regulates enamel patterning in mouse incisors by asymmetrically inhibiting BMP signaling and ameloblast differentiation. Dev Cell, 7:719-30. (PubMed:15525533)
70. Winnier G et al. (1995) Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev, 9:2105-16. (PubMed:7657163)
71. Xia Y et al. (2007) Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4. J Biol Chem, 282:18129-40. (PubMed:17472960)
72. Yamaji M et al. (2008) Critical function of Prdm14 for the establishment of the germ cell lineage in mice. Nat Genet, 40:1016-22. (PubMed:18622394)
73. Yu L et al. (2007) Shox2 is required for chondrocyte proliferation and maturation in proximal limb skeleton. Dev Biol, 306:549-59. (PubMed:17481601)
74. Zakin L et al. (2004) Inactivation of mouse Twisted gastrulation reveals its role in promoting Bmp4 activity during forebrain development. Development, 131:413-24. (PubMed:14681194)
75. Zhang Y et al. (1999) Msx1 is required for the induction of Patched by Sonic hedgehog in the mammalian tooth germ. Dev Dyn, 215:45-53. (PubMed:10340755)
76. Zhang Y et al. (2000) A new function of BMP4: dual role for BMP4 in regulation of Sonic hedgehog expression in the mouse tooth germ. Development, 127:1431-43. (PubMed:10704389)
77. Zhang Z et al. (2003) Msx1/Bmp4 genetic pathway regulates mammalian alveolar bone formation via induction of Dlx5 and Cbfa1. Mech Dev, 120:1469-79. (PubMed:14654219)
78. Zhu NL et al. (2007) TNF-alpha represses transcription of human Bone Morphogenetic Protein-4 in lung epithelial cells. Gene, 393:70-80. (PubMed:17350185)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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