Automated description from the Alliance of Genome Resources
Exhibits RNA polymerase II proximal promoter sequence-specific DNA binding activity; promoter-specific chromatin binding activity; and ubiquitin-protein transferase activator activity. Involved in several processes, including cellular protein modification process; chordate embryonic development; and positive regulation of lymphocyte proliferation. Localizes to the heterochromatin; nucleus; and ubiquitin ligase complex. Human ortholog(s) of this gene implicated in acute myeloid leukemia and colorectal carcinoma. Orthologous to several human genes including COMMD3-BMI1 (COMMD3-BMI1 readthrough).