Automated description from the Alliance of Genome Resources (Release 3.2)
Exhibits RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; promoter-specific chromatin binding activity; and ubiquitin-protein transferase activator activity. Involved in several processes, including chordate embryonic development; histone modification; and positive regulation of lymphocyte proliferation. Localizes to heterochromatin; nucleus; and ubiquitin ligase complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in acute myeloid leukemia; colorectal carcinoma; and hepatocellular carcinoma. Orthologous to several human genes including COMMD3-BMI1 (COMMD3-BMI1 readthrough).