Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Bdkrb1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Bdkrb1
  • participates in the following biological processes:
    • response to lipopolysaccharide ^[1]
  • performs the following molecular functions:
    • peptide binding ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Bdkrb1:
  • participates in the following biological processes:
    • cell migration
    • inflammatory response
    • negative regulation of blood pressure
    • negative regulation of cell growth
    • negative regulation of protein phosphorylation
    • positive regulation of leukocyte migration
    • positive regulation of release of sequestered calcium ion into cytosol
    • protein kinase C-activating G-protein coupled receptor signaling pathway
    • sensory perception of pain
  • performs the following molecular functions:
    • bradykinin receptor activity
    • peptide binding
  • is located in the following cellular components:
    • membrane
    • neuron projection
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Bdkrb1 encodes a protein or proteins that contain the following InterPro domains: B1 bradykinin receptor, Bradykinin receptor, GPCR, rhodopsin-like, GPCR, rhodopsin-like, 7TM, indicating that the gene product:
  • participates in the following biological processes:
    • elevation of cytosolic calcium ion concentration
    • G-protein coupled receptor signaling pathway
    • response to stress
  • is located in the following cellular components:
    • integral to membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Bdkrb1 indicates that it:
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway
    • signal transduction
  • performs the following molecular functions:
    • G-protein coupled receptor activity
    • signal transducer activity
  • is located in the following cellular components:
    • integral to membrane

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References

1. Pesquero JB et al. (1996) Molecular cloning and functional characterization of a mouse bradykinin B1 receptor gene. (Correction: vol 224(1): 281) Biochem Biophys Res Commun, 220:219-25. (PubMed:8602848)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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