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Gene Ontology Classifications
B cell leukemia/lymphoma 2

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Bcl2. (This text reflects annotations as of Tuesday, May 26, 2015.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of May 12, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text for additional MGI annotations
  1. Amling M et al. (1997) Bcl-2 lies downstream of parathyroid hormone-related peptide in a signaling pathway that regulates chondrocyte maturation during skeletal development. J Cell Biol, 136:205-13. (PubMed:9008714)
  2. Barge RM et al. (1997) Differential involvement of caspases in apoptosis of myeloid leukemic cells induced by chemotherapy versus growth factor withdrawal. FEBS Lett, 409:207-10. (PubMed:9202146)
  3. Boot-Handford RP et al. (1998) The bcl-2 knockout mouse exhibits marked changes in osteoblast phenotype and collagen deposition in bone as well as a mild growth plate phenotype. Int J Exp Pathol, 79:329-35. (PubMed:10193316)
  4. Borner C. (1996) Diminished cell proliferation associated with the death-protective activity of Bcl-2. J Biol Chem, 271:12695-8. (PubMed:8663032)
  5. Bouillet P et al. (2001) Degenerative Disorders Caused by Bcl-2 Deficiency Prevented by Loss of Its BH3-Only Antagonist Bim. Dev Cell, 1:645-53. (PubMed:11709185)
  6. Bouillet P et al. (2005) Polycystic kidney disease prevented by transgenic RNA interference. Cell Death Differ, 12:831-3. (PubMed:15818405)
  7. Broome HE et al. (1995) Apoptosis and Bcl-2 expression in cultured murine splenic T cells. Immunology, 84:375-82. (PubMed:7751019)
  8. Cellerino A et al. (1999) Retinal ganglion cell loss after the period of naturally occurring cell death in bcl-2-/- mice. Neuroreport, 10:1091-5. (PubMed:10321489)
  9. Chao DT et al. (1995) Bcl-XL and Bcl-2 repress a common pathway of cell death. J Exp Med, 182:821-8. (PubMed:7650488)
  10. Chen DF et al. (1997) Bcl-2 promotes regeneration of severed axons in mammalian CNS [see comments] Nature, 385:434-9. (PubMed:9009190)
  11. Chen M et al. (2007) Regulation of the lifespan in dendritic cell subsets. Mol Immunol, 44:2558-65. (PubMed:17267035)
  12. Cipolat S et al. (2006) Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling. Cell, 126:163-75. (PubMed:16839884)
  13. Cotter FE et al. (1994) Antisense oligonucleotides suppress B-cell lymphoma growth in a SCID-hu mouse model. Oncogene, 9:3049-55. (PubMed:8084613)
  14. Danial NN et al. (2008) Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nat Med, 14:144-53. (PubMed:18223655)
  15. Deng X et al. (2004) Mono- and multisite phosphorylation enhances Bcl2's antiapoptotic function and inhibition of cell cycle entry functions. Proc Natl Acad Sci U S A, 101:153-8. (PubMed:14660795)
  16. Deng X et al. (2003) Bcl2 retards G1/S cell cycle transition by regulating intracellular ROS. Blood, 102:3179-85. (PubMed:12855558)
  17. Dominov JA et al. (2001) Pro- and anti-apoptotic members of the bcl-2 family in skeletal muscle: A distinct role for bcl-2 in later stages of myogenesis Dev Dyn, 220:18-26. (PubMed:11146504)
  18. Dziarmaga A et al. (2006) Suppression of ureteric bud apoptosis rescues nephron endowment and adult renal function in Pax2 mutant mice. J Am Soc Nephrol, 17:1568-75. (PubMed:16672320)
  19. Einat H et al. (2005) Increased anxiety-like behaviors and mitochondrial dysfunction in mice with targeted mutation of the Bcl-2 gene: further support for the involvement of mitochondrial function in anxiety disorders. Behav Brain Res, 165:172-80. (PubMed:16095731)
  20. Erin N et al. (2003) Calcium-dependent interaction of calcineurin with Bcl-2 in neuronal tissue. Neuroscience, 117:541-55. (PubMed:12617961)
  21. Fleischer A et al. (2002) Proapoptotic activity of ITM2B(s), a BH3-only protein induced upon IL-2-deprivation which interacts with Bcl-2. Oncogene, 21:3181-9. (PubMed:12082633)
  22. Gillardon F et al. (1995) Up-regulation of bax and down-regulation of bcl-2 is associated with kainate-induced apoptosis in mouse brain. Neurosci Lett, 192:85-8. (PubMed:7675327)
  23. Gillardon F et al. (1995) Differential regulation of bcl-2, bax, c-fos, junB, and krox-24 expression in the cerebellum of Purkinje cell degeneration mutant mice. J Neurosci Res, 41:708-15. (PubMed:7563251)
  24. Gillardon F et al. (1999) Alterations in cell death and cell cycle progression in the UV-irradiated epidermis of bcl-2-deficient mice. Cell Death Differ, 6:55-60. (PubMed:10200548)
  25. Greenlund LJ et al. (1995) Role of BCL-2 in the survival and function of developing and mature sympathetic neurons. Neuron, 15:649-61. (PubMed:7546744)
  26. Hata R et al. (1999) Targeted disruption of the bcl-2 gene in mice exacerbates focal ischemic brain injury. Metab Brain Dis, 14:117-24. (PubMed:10488913)
  27. Hendry JH et al. (2000) Effects of deficiency in p53 or bcl-2 on the sensitivity of clonogenic cells in the small intestine to low dose-rate irradiation Int J Radiat Biol, 76:559-65. (PubMed:10815637)
  28. Hochman A et al. (1998) Enhanced oxidative stress and altered antioxidants in brains of Bcl-2-deficient mice. J Neurochem, 71:741-8. (PubMed:9681465)
  29. Hochman A et al. (2000) Developmental changes in antioxidant enzymes and oxidative damage in kidneys, liver and brain of bcl-2 knockout mice Cell Mol Biol (Noisy-Le-Grand), 46:41-52. (PubMed:10726970)
  30. Hou Y et al. (2007) c-Myc is essential for urokinase plasminogen activator expression on hypoxia-induced vascular smooth muscle cells. Cardiovasc Res, 75:186-94. (PubMed:17382917)
  31. Hu J et al. (2002) A novel transactivating factor that regulates interferon-gamma-dependent gene expression. J Biol Chem, 277:30253-63. (PubMed:12050152)
  32. Hughes P et al. (2006) Loss of PKD1 and loss of Bcl-2 elicit polycystic kidney disease through distinct mechanisms. Cell Death Differ, 13:1123-7. (PubMed:16282979)
  33. Jung KC et al. (2004) TCR-independent and caspase-independent apoptosis of murine thymocytes by CD24 cross-linking. J Immunol, 172:795-802. (PubMed:14707049)
  34. Jurgensmeier JM et al. (1998) Bax directly induces release of cytochrome c from isolated mitochondria. Proc Natl Acad Sci U S A, 95:4997-5002. (PubMed:9560217)
  35. Kamada S et al. (1995) bcl-2 deficiency in mice leads to pleiotropic abnormalities: accelerated lymphoid cell death in thymus and spleen, polycystic kidney, hair hypopigmentation, and distorted small intestine. Cancer Res, 55:354-9. (PubMed:7812968)
  36. Knudson CM et al. (1997) Bcl-2 and Bax function independently to regulate cell death. Nat Genet, 16:358-63. (PubMed:9241272)
  37. Kocher O et al. (2003) Targeted disruption of the PDZK1 gene in mice causes tissue-specific depletion of the high density lipoprotein receptor scavenger receptor class B type I and altered lipoprotein metabolism. J Biol Chem, 278:52820-5. (PubMed:14551195)
  38. Li T et al. (1996) Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes. Cell Growth Differ, 7:107-14. (PubMed:8788039)
  39. Limana F et al. (2002) bcl-2 overexpression promotes myocyte proliferation. Proc Natl Acad Sci U S A, 99:6257-62. (PubMed:11983915)
  40. Lin SS et al. (2006) PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum. J Biol Chem, 281:23003-12. (PubMed:16717086)
  41. Magnelli L et al. (1994) Bcl-2 overexpression abolishes early calcium waving preceding apoptosis in NIH-3T3 murine fibroblasts. Biochem Biophys Res Commun, 204:84-90. (PubMed:7945396)
  42. Mak SS et al. (2006) Indispensable role of Bcl2 in the development of the melanocyte stem cell. Dev Biol, 291:144-53. (PubMed:16427619)
  43. Matsuzaki Y et al. (1997) Role of bcl-2 in the development of lymphoid cells from the hematopoietic stem cell. Blood, 89:853-62. (PubMed:9028316)
  44. McGill GG et al. (2002) Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. Cell, 109:707-18. (PubMed:12086670)
  45. Merino R et al. (1994) Developmental regulation of the Bcl-2 protein and susceptibility to cell death in B lymphocytes. EMBO J, 13:683-91. (PubMed:8313913)
  46. Michaelidis TM et al. (1996) Inactivation of bcl-2 results in progressive degeneration of motoneurons, sympathetic and sensory neurons during early postnatal development. Neuron, 17:75-89. (PubMed:8755480)
  47. Middleton G et al. (2000) Differences in bcl-2- and bax-independent function in regulating apoptosis in sensory neuron populations. Eur J Neurosci, 12:819-27. (PubMed:10762311)
  48. Middleton G et al. (1998) Bcl-2 accelerates the maturation of early sensory neurons. J Neurosci, 18:3344-50. (PubMed:9547242)
  49. Middleton G et al. (1996) Bax promotes neuronal survival and antagonises the survival effects of neurotrophic factors. Development, 122:695-701. (PubMed:8625820)
  50. Mizuguchi M et al. (1994) Expression of Bcl-2 protein in murine neural cells in culture. Brain Res, 649:197-202. (PubMed:7953633)
  51. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell, 115:629-40. (PubMed:14651853)
  52. Mostafapour SP et al. (2000) Patterns of cell death in mouse anteroventral cochlear nucleus neurons after unilateral cochlea removal J Comp Neurol, 426:561-71. (PubMed:11027399)
  53. Moujalled D et al. (2011) Cyclic-AMP-dependent protein kinase A regulates apoptosis by stabilizing the BH3-only protein Bim. EMBO Rep, 12:77-83. (PubMed:21151042)
  54. Mu J et al. (2003) Apoptosis and related proteins in placenta of intrauterine fetal death in prostaglandin f receptor-deficient mice. Biol Reprod, 68:1968-74. (PubMed:12606450)
  55. Muller-Rover S et al. (1999) Hair follicle apoptosis and Bcl-2. J Investig Dermatol Symp Proc, 4:272-7. (PubMed:10674380)
  56. Myers KM et al. (1995) Bcl-2 protects neural cells from cyanide/aglycemia-induced lipid oxidation, mitochondrial injury, and loss of viability. J Neurochem, 65:2432-40. (PubMed:7595537)
  57. Nagata M et al. (1996) Apoptosis during an early stage of nephrogenesis induces renal hypoplasia in bcl-2-deficient mice. Am J Pathol, 148:1601-11. (PubMed:8623928)
  58. Nakamura N et al. (2003) Sorting specificity of spermatogenic cell specific region of mouse hexokinase-s (mHk1-s). Mol Reprod Dev, 64:113-9. (PubMed:12420306)
  59. Nakayama K et al. (1994) Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia. Proc Natl Acad Sci U S A, 91:3700-4. (PubMed:8170972)
  60. Nakayama K et al. (1993) Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice. Science, 261:1584-8. (PubMed:8372353)
  61. Narita M et al. (1998) Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. Proc Natl Acad Sci U S A, 95:14681-6. (PubMed:9843949)
  62. Novack DV et al. (1994) Bcl-2 protein expression during murine development [see comments] Am J Pathol, 145:61-73. (PubMed:8030757)
  63. Oakes SA et al. (2005) Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum. Proc Natl Acad Sci U S A, 102:105-10. (PubMed:15613488)
  64. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)
  65. Pinon LG et al. (1997) Bcl-2 is required for cranial sensory neuron survival at defined stages of embryonic development. Development, 124:4173-8. (PubMed:9374413)
  66. Pritchard DM et al. (1999) Damage-induced apoptosis in intestinal epithelia from bcl-2-null and bax-null mice: investigations of the mechanistic determinants of epithelial apoptosis in vivo. Oncogene, 18:7287-93. (PubMed:10602483)
  67. Przemeck SM et al. (2007) Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2. Am J Physiol Gastrointest Liver Physiol, 292:G620-7. (PubMed:17068116)
  68. Putcha GV et al. (2002) Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice. J Cell Biol, 157:441-53. (PubMed:11980919)
  69. Puthalakath H et al. (2001) Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis. Science, 293:1829-32. (PubMed:11546872)
  70. Ratts VS et al. (1995) Ablation of bcl-2 gene expression decreases the numbers of oocytes and primordial follicles established in the post-natal female mouse gonad. Endocrinology, 136:3665-8. (PubMed:7628407)
  71. Sagot Y et al. (1995) Bcl-2 overexpression prevents motoneuron cell body loss but not axonal degeneration in a mouse model of a neurodegenerative disease. J Neurosci, 15:7727-33. (PubMed:7472523)
  72. Sciortino MT et al. (2006) Role of Bcl-2 expression for productive herpes simplex virus 2 replication. Virology, 356:136-46. (PubMed:16950491)
  73. Sorenson CM. (2004) Interaction of bcl-2 with Paxillin through its BH4 domain is important during ureteric bud branching. J Biol Chem, 279:11368-74. (PubMed:14699151)
  74. Sorenson CM. (1999) Nuclear localization of beta-catenin and loss of apical brush border actin in cystic tubules of bcl-2 -/- mice. Am J Physiol, 276:F210-7. (PubMed:9950951)
  75. Sorenson CM et al. (1996) Abnormal postpartum renal development and cystogenesis in the bcl-2 (-/-) mouse. Am J Physiol, 271:F184-93. (PubMed:8760259)
  76. Sorenson CM et al. (1995) Fulminant metanephric apoptosis and abnormal kidney development in bcl-2-deficient mice. Am J Physiol, 268:F73-81. (PubMed:7840250)
  77. Takayama S et al. (1995) Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity. Cell, 80:279-84. (PubMed:7834747)
  78. Tanabe H et al. (1997) Susceptibility of cerebellar granule neurons derived from Bcl-2-deficient and transgenic mice to cell death. Eur J Neurosci, 9:848-56. (PubMed:9153592)
  79. Tang D et al. (2010) Endogenous HMGB1 regulates autophagy. J Cell Biol, 190:881-92. (PubMed:20819940)
  80. Teijido O et al. (2010) Upregulation of Bcl2 inhibits apoptosis-driven BAX insertion but favors BAX relocalization in mitochondria. FEBS Lett, 584:3305-10. (PubMed:20621101)
  81. Veis DJ et al. (1993) Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell, 75:229-40. (PubMed:8402909)
  82. Vila M et al. (2001) Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. Proc Natl Acad Sci U S A, 98:2837-42. (PubMed:11226327)
  83. von Freeden-Jeffry U et al. (1997) The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression. Immunity, 7:147-54. (PubMed:9252127)
  84. Vukosavic S et al. (1999) Bax and Bcl-2 interaction in a transgenic mouse model of familial amyotrophic lateral sclerosis. J Neurochem, 73:2460-8. (PubMed:10582606)
  85. Wlodarczyk BC et al. (1996) Valproic acid-induced changes in gene expression during neurulation in a mouse model. Teratology, 54:284-97. (PubMed:9098922)
  86. Wojciechowski S et al. (2007) Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis. J Exp Med, 204:1665-75. (PubMed:17591857)
  87. Yamamura K et al. (1996) Accelerated disappearance of melanocytes in bcl-2-deficient mice. Cancer Res, 56:3546-50. (PubMed:8758925)
  88. Yang E et al. (1995) Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell, 80:285-91. (PubMed:7834748)
  89. Zhang H et al. (2008) Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J Biol Chem, 283:10892-903. (PubMed:18281291)
  90. Ziehr J et al. (2004) Alterations in cell-adhesive and migratory properties of proximal tubule and collecting duct cells from bcl-2 -/- mice. Am J Physiol Renal Physiol, 287:F1154-63. (PubMed:15292044)

Go Annotations in Tabular Form (Text View) (GO Graph)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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