Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Avpr2. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

This gene encodes a member of the G-protein coupled receptor 1 family and the vasopressin/oxytocin receptor subfamily. The encoded protein is an arginine vasopressin receptor which, when stimulated, activates the Gs protein/adenylyl cyclase signaling cascade and is involved in water and electrolyte homeostasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Avpr2
  • participates in the following biological processes:
    • I-kappaB kinase/NF-kappaB cascade ^[1]
    • interferon-gamma production ^[1]
    • response to cytokine stimulus ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Avpr2:
  • participates in the following biological processes:
    • negative regulation of renal sodium excretion
    • negative regulation of urine volume
    • positive regulation of blood pressure
    • positive regulation of cell proliferation
    • positive regulation of gene expression
    • positive regulation of systemic arterial blood pressure
  • performs the following molecular functions:
    • vasopressin receptor activity

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Summary text based on GO annotations supported by structural data

• Avpr2 encodes a protein or proteins that contain the following InterPro domains: G protein-coupled receptor, rhodopsin-like, GPCR, rhodopsin-like, 7TM, Vasopressin receptor, Vasopressin V2 receptor, indicating that the gene product:
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway
  • performs the following molecular functions:
    • G-protein coupled receptor activity
  • is located in the following cellular components:
    • integral to membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Avpr2 indicates that it:
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway
    • signal transduction
  • performs the following molecular functions:
    • G-protein coupled receptor activity
    • signal transducer activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane
    • plasma membrane

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References

1. Thomas JA et al. (1999) Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase. J Immunol, 163:978-84. (PubMed:10395695)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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