Automated description from the Alliance of Genome Resources (Release 3.1)
Exhibits several functions, including calcium ion binding activity; calcium transmembrane transporter activity, phosphorylative mechanism; and protein C-terminus binding activity. Involved in several processes, including T-tubule organization; cardiac muscle hypertrophy in response to stress; and regulation of heart contraction. Localizes to endoplasmic reticulum membrane; ribbon synapse; and sarcoplasmic reticulum. Predicted to colocalize with intercalated disc. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Used to study keratosis follicularis. Human ortholog(s) of this gene implicated in acrokeratosis verruciformis; essential hypertension; keratosis follicularis; and pulmonary hypertension. Orthologous to human ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2).