Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Atp2a2. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Atp2a2
  • participates in the following biological processes:
    • ATP catabolic process ^{[4, 7]}
    • calcium ion transmembrane transport ^{[4, 7]}
    • cellular calcium ion homeostasis ^[4]
  • performs the following molecular functions:
    • calcium-transporting ATPase activity ^{[4, 7]}
  • is located in the following cellular components:
    • membrane ^[5]
    • sarcoplasmic reticulum ^[2]
• The gene product of Atp2a2 has been shown to bind to the gene products of Pln. ^{[1, 3]} Researchers have inferred, based on physical interactions, that the gene product of Atp2a2
  • performs the following molecular functions:
    • protein C-terminus binding ^[9]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Atp2a2
  • participates in the following biological processes:
    • cellular calcium ion homeostasis ^[7]
    • ER-nucleus signaling pathway ^[8]
• Researchers have inferred, based on genetic interactions, that the gene product of Atp2a2
  • participates in the following biological processes:
    • cellular calcium ion homeostasis based on interactions with Hexb ^[7]
    • negative regulation of heart contraction based on interactions with Pln ^[6]
    • regulation of the force of heart contraction based on interactions with Pln ^[6]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Atp2a2:
  • participates in the following biological processes:
    • ATP catabolic process
    • calcium ion transport
    • response to peptide hormone stimulus
    • sarcoplasmic reticulum calcium ion transport
  • performs the following molecular functions:
    • ATP binding
    • calcium ion binding
    • calcium-transporting ATPase activity
    • lutropin-choriogonadotropic hormone receptor binding
    • protein C-terminus binding
    • S100 protein binding
  • is located in the following cellular components:
    • endoplasmic reticulum membrane
    • protein complex
    • sarcoplasmic reticulum
    • vesicle membrane

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Summary text based on GO annotations supported by structural data

• Atp2a2 encodes a protein or proteins that contain the following InterPro domains: ATPase, P-type, cytoplasmic transduction domain A, ATPase, cation-transporting, domain N, ATPase, P-type cation-transporter, C-terminal, ATPase, P-type cation-transporter, N-terminal, ATPase, P-type phosphorylation site, ATPase, P-type, transmembrane domain, ATPase, P-type, ATPase-associated domain, ATPase, P-type, calcium-transporting, ATPase, P-type, cytoplasmic domain N, ATPase, P-type, H+ transporting proton pump, ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter, HAD-like domain, Haloacid dehalogenase-like hydrolase, indicating that the gene product:
  • participates in the following biological processes:
    • cation transport
  • performs the following molecular functions:
    • cation-transporting ATPase activity
    • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    • metal ion binding
    • nucleotide binding
  • is located in the following cellular components:
    • integral to membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Atp2a2 indicates that it:
  • participates in the following biological processes:
    • ion transport
    • transport
  • performs the following molecular functions:
    • hydrolase activity
    • metal ion binding
    • nucleotide binding
  • is located in the following cellular components:
    • endoplasmic reticulum
    • integral to membrane

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References

1. Asahi M et al. (2004) Cardiac-specific overexpression of sarcolipin inhibits sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a) activity and impairs cardiac function in mice. Proc Natl Acad Sci U S A, 101:9199-204. (PubMed:15201433)
2. Harrer JM et al. (1997) Coordinate regulation of SR Ca(2+)-ATPase and phospholamban expression in developing murine heart. Am J Physiol, 272:H57-66. (PubMed:9038922)
3. Huang G et al. (2006) ER stress disrupts Ca2+-signaling complexes and Ca2+ regulation in secretory and muscle cells from PERK-knockout mice. J Cell Sci, 119:153-61. (PubMed:16352659)
4. Ji Y et al. (1999) SERCA1a can functionally substitute for SERCA2a in the heart. Am J Physiol, 276:H89-97. (PubMed:9887021)
5. Li XF et al. (2006) Importance of K+-dependent Na+/Ca2+-exchanger 2, NCKX2, in motor learning and memory. J Biol Chem, 281:6273-82. (PubMed:16407245)
6. Minamisawa S et al. (1999) Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy. Cell, 99:313-22. (PubMed:10555147)
7. Pelled D et al. (2003) Inhibition of calcium uptake via the sarco/endoplasmic reticulum Ca2+-ATPase in a mouse model of Sandhoff disease and prevention by treatment with N-butyldeoxynojirimycin. J Biol Chem, 278:29496-501. (PubMed:12756243)
8. Rao RV et al. (2004) Molecular components of a cell death pathway activated by endoplasmic reticulum stress. J Biol Chem, 279:177-87. (PubMed:14561754)
9. Stefanovic B et al. (2004) TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis. Mol Cell Biol, 24:1758-68. (PubMed:14749390)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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