Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Atp1a3. (This text reflects annotations as of Thursday, July 24, 2014.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of April 17, 2007. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Atp1a3
  • is located in the following cellular components:
    • cytoplasm ^[1]
    • nucleus ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Atp1a3
  • participates in the following biological processes:
    • adult locomotory behavior ^[2]
    • ionotropic glutamate receptor signaling pathway ^[2]
    • memory ^[2]
    • response to drug ^[2]
    • visual learning ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Atp1a3:
  • participates in the following biological processes:
    • ATP catabolic process
    • potassium ion transmembrane transport
    • potassium ion transport
    • sodium ion transmembrane transport
    • sodium ion transport
  • performs the following molecular functions:
    • D1 dopamine receptor binding
    • sodium:potassium-exchanging ATPase activity
  • is located in the following cellular components:
    • axon
    • dendritic spine head
    • dendritic spine neck
    • endoplasmic reticulum
    • Golgi apparatus
    • myelin sheath
    • sodium:potassium-exchanging ATPase complex
    • synapse

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Summary text based on GO annotations supported by structural data

• Atp1a3 encodes a protein or proteins that contain the following InterPro domains: Cation-transporting P-type ATPase, Cation-transporting P-type ATPase, C-terminal, Cation-transporting P-type ATPase, N-terminal, HAD-like domain, P-type ATPase, transmembrane domain, P-type ATPase, A domain, P-type ATPase, cytoplasmic domain N, P-type ATPase, phosphorylation site, Sodium/potassium-transporting P-type ATPase, subfamily IIC, indicating that the gene product:
  • participates in the following biological processes:
    • ATP biosynthetic process
    • cation transport
    • monovalent inorganic cation transport
  • performs the following molecular functions:
    • ATP binding
    • cation-transporting ATPase activity
    • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    • metal ion binding
    • monovalent inorganic cation transmembrane transporter activity
    • nucleotide binding
  • is located in the following cellular components:
    • integral component of membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Atp1a3 indicates that it:
  • participates in the following biological processes:
    • ion transport
    • transport
  • performs the following molecular functions:
    • ATP binding
    • hydrolase activity
    • metal ion binding
    • nucleotide binding
  • is located in the following cellular components:
    • integral component of membrane
    • membrane

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References

1. MacPhee DJ et al. (2000) Differential involvement of Na(+),K(+)-ATPase isozymes in preimplantation development of the mouse. Dev Biol, 222:486-98. (PubMed:10837135)
2. Moseley AE et al. (2007) Deficiency in Na,K-ATPase alpha isoform genes alters spatial learning, motor activity, and anxiety in mice. J Neurosci, 27:616-26. (PubMed:17234593)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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