Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Atp1a1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Atp1a1
  • is located in the following cellular components:
    • basolateral plasma membrane ^[1]
    • plasma membrane ^{[6, 9]}
    • sarcolemma ^{[2, 7]}
    • T-tubule ^[7]
• The gene product of Atp1a1 has been shown to bind to the gene products of Ank2, Slc8a1. ^{[2, 7]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Atp1a1
  • participates in the following biological processes:
    • ATP catabolic process ^{[2, 5]}
    • dephosphorylation ^[5]
    • negative regulation of glucocorticoid biosynthetic process ^[8]
    • negative regulation of heart contraction ^[2]
    • positive regulation of heart contraction ^[5]
    • positive regulation of striated muscle contraction ^[4]
    • regulation of the force of heart contraction ^{[2, 5]}
    • response to drug ^[8]
    • sodium ion transmembrane transport ^{[2, 5]}
  • performs the following molecular functions:
    • 4-nitrophenylphosphatase activity ^[5]
    • sodium:potassium-exchanging ATPase activity ^{[2, 5]}
• Researchers have inferred, based on genetic interactions, that the gene product of Atp1a1
  • participates in the following biological processes:
    • regulation of blood pressure based on interactions with Pomc ^[3]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Atp1a1:
  • participates in the following biological processes:
    • cellular response to mechanical stimulus
    • membrane hyperpolarization
    • potassium ion import
    • potassium ion transport
    • regulation of cardiac muscle cell contraction
    • regulation of sodium ion transport
    • sodium ion transport
  • performs the following molecular functions:
    • ADP binding
    • ankyrin binding
    • ATP binding
    • chaperone binding
    • phosphatidylinositol 3-kinase binding
    • potassium ion binding
    • protein domain specific binding
    • protein kinase binding
    • sodium ion binding
    • sodium:potassium-exchanging ATPase activity
  • is located in the following cellular components:
    • caveola
    • endoplasmic reticulum
    • endosome
    • Golgi apparatus
    • membrane
    • membrane raft
    • plasma membrane
    • sodium:potassium-exchanging ATPase complex

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Summary text based on GO annotations supported by structural data

• Atp1a1 encodes a protein or proteins that contain the following InterPro domains: ATPase, P-type, cytoplasmic transduction domain A, ATPase, cation-transporting, domain N, ATPase, P-type cation exchange, alpha subunit, ATPase, P-type cation exchange, alpha subunit, eukaryotic, ATPase, P-type cation-transporter, C-terminal, ATPase, P-type cation-transporter, N-terminal, ATPase, P-type phosphorylation site, ATPase, P-type, transmembrane domain, ATPase, P-type, ATPase-associated domain, ATPase, P-type, cytoplasmic domain N, ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter, HAD-like domain, Haloacid dehalogenase-like hydrolase, indicating that the gene product:
  • participates in the following biological processes:
    • ATP biosynthetic process
    • cation transport
    • monovalent inorganic cation transport
  • performs the following molecular functions:
    • cation-transporting ATPase activity
    • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    • metal ion binding
    • monovalent inorganic cation transmembrane transporter activity
    • nucleotide binding
  • is located in the following cellular components:
    • integral to membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Atp1a1 indicates that it:
  • participates in the following biological processes:
    • ion transport
    • transport
  • performs the following molecular functions:
    • hydrolase activity
    • metal ion binding
    • nucleotide binding
  • is located in the following cellular components:
    • integral to membrane

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References

1. Avner ED. (1993) Epithelial polarity and differentiation in polycystic kidney disease. J Cell Sci Suppl, 17:217-22. (PubMed:8144700)
2. Dostanic I et al. (2004) The alpha 1 isoform of Na,K-ATPase regulates cardiac contractility and functionally interacts and co-localizes with the Na/Ca exchanger in heart. J Biol Chem, 279:54053-61. (PubMed:15485817)
3. Dostanic-Larson I et al. (2005) The highly conserved cardiac glycoside binding site of Na,K-ATPase plays a role in blood pressure regulation. Proc Natl Acad Sci U S A, 102:15845-50. (PubMed:16243970)
4. He S et al. (2001) The alpha(1)- and alpha(2)-isoforms of Na-K-ATPase play different roles in skeletal muscle contractility. Am J Physiol Regul Integr Comp Physiol, 281:R917-25. (PubMed:11507009)
5. James PF et al. (1999) Identification of a specific role for the Na,K-ATPase alpha 2 isoform as a regulator of calcium in the heart. Mol Cell, 3:555-63. (PubMed:10360172)
6. MacPhee DJ et al. (2000) Differential involvement of Na(+),K(+)-ATPase isozymes in preimplantation development of the mouse. Dev Biol, 222:486-98. (PubMed:10837135)
7. Mohler PJ et al. (2005) Ankyrin-B coordinates the Na/K ATPase, Na/Ca exchanger, and InsP3 receptor in a cardiac T-tubule/SR microdomain. PLoS Biol, 3:e423. (PubMed:16292983)
8. Moseley AE et al. (2007) Deficiency in Na,K-ATPase alpha isoform genes alters spatial learning, motor activity, and anxiety in mice. J Neurosci, 27:616-26. (PubMed:17234593)
9. Yang SN et al. (1999) Syntaxin 1 interacts with the L(D) subtype of voltage-gated Ca(2+) channels in pancreatic beta cells. Proc Natl Acad Sci U S A, 96:10164-9. (PubMed:10468580)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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