Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Serpinc1. (This text reflects annotations as of Thursday, July 24, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Serpinc1:
  • participates in the following biological processes:
    • negative regulation of endopeptidase activity
    • negative regulation of inflammatory response
    • regulation of proteolysis
    • response to nutrient
  • performs the following molecular functions:
    • heparin binding
    • protease binding
    • serine-type endopeptidase inhibitor activity
  • is located in the following cellular components:
    • blood microparticle
    • extracellular region
    • extracellular space
    • extracellular vesicular exosome

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Summary text based on GO annotations supported by structural data

• Serpinc1 encodes a protein or proteins that contain the following InterPro domains: Antithrombin-III, Protease inhibitor I4, serpin, conserved site, Serpin domain, Serpin family, indicating that the gene product:
  • participates in the following biological processes:
    • regulation of blood coagulation, intrinsic pathway

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Serpinc1 indicates that it:
  • participates in the following biological processes:
    • blood coagulation
    • hemostasis
    • negative regulation of peptidase activity
  • performs the following molecular functions:
    • peptidase inhibitor activity

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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