Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Arsb. (This text reflects annotations as of Wednesday, January 23, 2013.)

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Arylsulfatase B encoded by this gene belongs to the sulfatase family. The arylsulfatase B homodimer hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate. The protein is targetted to the lysozyme. Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Arsb
  • participates in the following biological processes:
    • metabolic process ^[1]
  • performs the following molecular functions:
    • arylsulfatase activity ^[1]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Arsb:
  • participates in the following biological processes:
    • autophagy
    • central nervous system development
    • response to estrogen stimulus
    • response to methylmercury
    • response to nutrient
    • response to pH
  • performs the following molecular functions:
    • sulfuric ester hydrolase activity
  • is located in the following cellular components:
    • Golgi apparatus
    • lysosome
    • mitochondrion
    • rough endoplasmic reticulum

---

Summary text based on GO annotations supported by structural data

• Arsb encodes a protein or proteins that contain the following InterPro domains: Alkaline phosphatase-like, alpha/beta/alpha, Alkaline-phosphatase-like, core domain, Sulfatase, Sulfatase, conserved site, indicating that the gene product:
  • performs the following molecular functions:
    • catalytic activity

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Arsb indicates that it:
  • performs the following molecular functions:
    • hydrolase activity
    • metal ion binding
• Arsb has been associated with the Enzyme Commission numbers: 3.1.6.12, which implies that the gene product:
  • performs the following molecular functions:
    • N-acetylgalactosamine-4-sulfatase activity

---

References

1. Daniel WL et al. (1980) Comparative biochemistry of murine arylsulfatase B. Biochem Genet, 18:625-42. (PubMed:7470017)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---