Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Arg1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Arg1
  • participates in the following biological processes:
    • metabolic process ^[1]
  • performs the following molecular functions:
    • arginase activity ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Arg1:
  • participates in the following biological processes:
    • arginine metabolic process
    • collagen biosynthetic process
    • positive regulation of endothelial cell proliferation
    • protein homotrimerization
    • regulation of L-arginine import
    • urea cycle
  • performs the following molecular functions:
    • arginase activity
    • manganese ion binding
  • is located in the following cellular components:
    • cytoplasm
    • extracellular space
    • neuron projection
    • neuronal cell body

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Summary text based on GO annotations supported by structural data

• Arg1 encodes a protein or proteins that contain the following InterPro domains: Arginase, Ureohydrolase, Ureohydrolase domain, Ureohydrolase, manganese-binding site, indicating that the gene product:
  • participates in the following biological processes:
    • metabolic process
  • performs the following molecular functions:
    • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
    • metal ion binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Arg1 indicates that it:
  • participates in the following biological processes:
    • metabolic process
  • performs the following molecular functions:
    • hydrolase activity
    • metal ion binding

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References

1. Rout UK et al. (1997) Ethanol-induced intracellular calcium mobilization rapidly alters gene expression in the mouse blastocyst. Cell Calcium, 22:463-74. (PubMed:9502196)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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