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Gene Ontology Classifications
Symbol
Name
ID
App
amyloid beta (A4) precursor protein
MGI:88059

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of App. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Akaaboune M et al. (2000) Developmental regulation of amyloid precursor protein at the neuromuscular junction in mouse skeletal muscle. Mol Cell Neurosci, 15:355-67. (PubMed:10845772)
  2. Apert C et al. (1998) Profiles of amyloid precursor and presenilin 2-like proteins are correlated during development of the mouse hypothalamus. J Neuroendocrinol, 10:101-9. (PubMed:9535056)
  3. Bai Y et al. (2008) The in vivo brain interactome of the amyloid precursor protein. Mol Cell Proteomics, 7:15-34. (PubMed:17934213)
  4. Bellingham SA et al. (2004) Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cellular copper levels in primary mouse cortical neurons and embryonic fibroblasts. J Neurochem, 91:423-8. (PubMed:15447675)
  5. Cao Q et al. (2005) Amyloid precursor proteins anchor CPEB to membranes and promote polyadenylation-induced translation. Mol Cell Biol, 25:10930-9. (PubMed:16314516)
  6. Dawson GR et al. (1999) Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the beta-amyloid precursor protein. Neuroscience, 90:1-13. (PubMed:10188929)
  7. Duce JA et al. (2010) Iron-export ferroxidase activity of beta-amyloid precursor protein is inhibited by zinc in Alzheimer's disease. Cell, 142:857-67. (PubMed:20817278)
  8. Fukami S et al. (2002) Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology. Neurosci Res, 43:39-56. (PubMed:12074840)
  9. Hashimoto Y et al. (2005) Transforming growth factor beta2 is a neuronal death-inducing ligand for amyloid-beta precursor protein. Mol Cell Biol, 25:9304-17. (PubMed:16227582)
  10. Herms J et al. (2003) Capacitive calcium entry is directly attenuated by mutant presenilin-1, independent of the expression of the amyloid precursor protein. J Biol Chem, 278:2484-9. (PubMed:12431992)
  11. Herms J et al. (2004) Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members. EMBO J, 23:4106-15. (PubMed:15385965)
  12. Homayouni R et al. (1999) Disabled-1 binds to the cytoplasmic domain of amyloid precursor-like protein 1. J Neurosci, 19:7507-15. (PubMed:10460257)
  13. Jin LW et al. (1994) Peptides containing the RERMS sequence of amyloid beta/A4 protein precursor bind cell surface and promote neurite extension. J Neurosci, 14:5461-70. (PubMed:8083748)
  14. Kamal A et al. (2001) Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP. Nature, 414:643-8. (PubMed:11740561)
  15. Lazarov O et al. (2005) Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited. J Neurosci, 25:2386-95. (PubMed:15745965)
  16. Liang Y et al. (2013) The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells. Nat Immunol, 14:858-66. (PubMed:23793062)
  17. Liu Q et al. (2007) Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1. Neuron, 56:66-78. (PubMed:17920016)
  18. Lopez-Sanchez N et al. (2005) Lengthening of G2/mitosis in cortical precursors from mice lacking beta-amyloid precursor protein. Neuroscience, 130:51-60. (PubMed:15561424)
  19. Ma QH et al. (2008) A TAG1-APP signalling pathway through Fe65 negatively modulates neurogenesis. Nat Cell Biol, 10:283-94. (PubMed:18278038)
  20. Magara F et al. (1999) Genetic background changes the pattern of forebrain commissure defects in transgenic mice underexpressing the beta-amyloid-precursor protein. Proc Natl Acad Sci U S A, 96:4656-61. (PubMed:10200318)
  21. Mameza MG et al. (2007) Characterization of the adaptor protein ARH expression in the brain and ARH molecular interactions. J Neurochem, 103:927-41. (PubMed:17727637)
  22. Matsuda S et al. (2001) c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK. J Neurosci, 21:6597-607. (PubMed:11517249)
  23. Merte J et al. (2010) Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure. Nat Cell Biol, 12:41-6; sup pp 1-8. (PubMed:19966784)
  24. Minopoli G et al. (2007) Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage. J Biol Chem, 282:831-5. (PubMed:17121854)
  25. Mohmmad Abdul H et al. (2006) Mutations in amyloid precursor protein and presenilin-1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid beta-peptide (1-42), HO and kainic acid: implications for J Neurochem, 96:1322-35. (PubMed:16478525)
  26. Muller U et al. (1994) Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene. Cell, 79:755-65. (PubMed:8001115)
  27. Muresan Z et al. (2005) Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1. J Cell Biol, 171:615-25. (PubMed:16301330)
  28. Pardossi-Piquard R et al. (2005) Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP. Neuron, 46:541-54. (PubMed:15944124)
  29. Perez RG et al. (1997) The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity. J Neurosci, 17:9407-14. (PubMed:9390996)
  30. Pham E et al. (2010) Progressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins. FEBS J, 277:3051-67. (PubMed:20573181)
  31. Phinney AL et al. (1999) No hippocampal neuron or synaptic bouton loss in learning-impaired aged beta-amyloid precursor protein-null mice. Neuroscience, 90:1207-16. (PubMed:10338291)
  32. Ranganathan S et al. (2011) LRAD3, A Novel Low-Density Lipoprotein Receptor Family Member That Modulates Amyloid Precursor Protein Trafficking. J Neurosci, 31:10836-10846. (PubMed:21795536)
  33. Rouvinski A et al. (2003) Both raft- and non-raft proteins associate with CHAPS-insoluble complexes: some APP in large complexes. Biochem Biophys Res Commun, 308:750-8. (PubMed:12927782)
  34. Salbaum JM et al. (1994) Embryonic expression pattern of amyloid protein precursor suggests a role in differentiation of specific subsets of neurons. J Exp Zool, 269:116-27. (PubMed:8207383)
  35. Seabrook GR et al. (1999) Mechanisms contributing to the deficits in hippocampal synaptic plasticity in mice lacking amyloid precursor protein. Neuropharmacology, 38:349-59. (PubMed:10219973)
  36. Snyder EM et al. (2005) Regulation of NMDA receptor trafficking by amyloid-beta. Nat Neurosci, 8:1051-8. (PubMed:16025111)
  37. Soba P et al. (2005) Homo- and heterodimerization of APP family members promotes intercellular adhesion. EMBO J, 24:3624-34. (PubMed:16193067)
  38. Stemmer N et al. (2013) Generation of amyloid-beta is reduced by the interaction of calreticulin with amyloid precursor protein, presenilin and nicastrin. PLoS One, 8:e61299. (PubMed:23585889)
  39. Steuble M et al. (2010) Molecular characterization of a trafficking organelle: dissecting the axonal paths of calsyntenin-1 transport vesicles. Proteomics, 10:3775-88. (PubMed:20925061)
  40. Tarr PE et al. (2002) Tyrosine phosphorylation of the Beta -amyloid precursor protein cytoplasmic tail promotes interaction with shc. J Biol Chem, 277:16798-804. (PubMed:11877420)
  41. Tremml P et al. (1998) Neurobehavioral development, adult openfield exploration and swimming navigation learning in mice with a modified beta-amyloid precursor protein gene. Behav Brain Res, 95:65-76. (PubMed:9754878)
  42. Tummala H et al. (2010) Interaction of a novel mitochondrial protein, 4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (NIPSNAP1), with the amyloid precursor protein family. Eur J Neurosci, 31:1926-34. (PubMed:20497468)
  43. Vetrivel KS et al. (2005) Spatial segregation of gamma-secretase and substrates in distinct membrane domains. J Biol Chem, 280:25892-900. (PubMed:15886206)
  44. von Koch CS et al. (1997) Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice. Neurobiol Aging, 18:661-9. (PubMed:9461064)
  45. Vossel KA et al. (2010) Tau reduction prevents Abeta-induced defects in axonal transport. Science, 330:198. (PubMed:20829454)
  46. Wang P et al. (2005) Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2. J Neurosci, 25:1219-25. (PubMed:15689559)
  47. White AR et al. (1999) Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice. Brain Res, 842:439-44. (PubMed:10526140)
  48. Yang J et al. (2005) The ciliary rootlet interacts with kinesin light chains and may provide a scaffold for kinesin-1 vesicular cargos. Exp Cell Res, 309:379-89. (PubMed:16018997)
  49. Yang Y et al. (2004) Presenilin-1 and intracellular calcium stores regulate neuronal glutamate uptake. J Neurochem, 88:1361-72. (PubMed:15009636)
  50. Yun M et al. (2003) Crystal structures of the Dab homology domains of mouse disabled 1 and 2. J Biol Chem, 278:36572-81. (PubMed:12826668)
  51. Zhang YW et al. (2007) Presenilin/{gamma}-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression. Proc Natl Acad Sci U S A, 104:10613-8. (PubMed:17556541)
  52. Zheng H et al. (1995) beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity. Cell, 81:525-31. (PubMed:7758106)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory