Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; low-density lipoprotein particle receptor binding activity; and signaling receptor activator activity. Involved in several processes, including cellular metal ion homeostasis; nervous system development; and regulation of gene expression. Localizes to several cellular components, including cytoplasmic vesicle; cytoskeleton; and neuromuscular junction. Predicted to colocalize with several cellular components, including high-density lipoprotein particle; low-density lipoprotein particle; and very-low-density lipoprotein particle. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; neurogenic placode; and sensory organ. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in APP-related cerebral amyloid angiopathy; Alzheimer's disease; Alzheimer's disease 1; cognitive disorder; and visual epilepsy. Orthologous to human APP (amyloid beta precursor protein).