Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Apoc3. (This text reflects annotations as of Thursday, July 24, 2014.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of October 26, 2007. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

This gene encodes an apolipoprotein which is the major protein component of very-low-density lipoproteins (VLDL) and a minor component of high-density lipoproteins (HDL). The encoded protein is thought to regulate the metabolism of triglyceride-rich lipoproteins and play a role in lipid storage and the mobilization of fat cells. This gene is clustered with three other apolipoprotein genes on chromosome 9 and is associated with coronary disease. Mice lacking this gene have lower levels of total cholesterol in the plasma. Mutations in the human genes causes hyperalphalipoproteinemia 2, a disorder of lipid metabolism which results in a favorable lipid profile (lower LDL-cholesterol, higher HDL-cholesterol and lower levels of serum triglycerides when fasting and after a meal). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Apoc3
  • participates in the following biological processes:
    • cholesterol metabolic process ^{[1, 3, 4]}
    • triglyceride catabolic process ^[3]
    • triglyceride metabolic process ^{[3, 4]}
    • triglyceride mobilization ^{[1, 2]}

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Apoc3:
  • participates in the following biological processes:
    • cellular response to glucose stimulus
    • lipoprotein transport
    • response to peptide hormone
  • is located in the following cellular components:
    • extracellular space

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Summary text based on GO annotations supported by structural data

• Apoc3 encodes a protein or proteins that contain the following InterPro domains: Apolipoprotein CIII, indicating that the gene product:
  • participates in the following biological processes:
    • lipid transport
    • lipoprotein metabolic process
  • performs the following molecular functions:
    • lipid binding
  • is located in the following cellular components:
    • extracellular region

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Apoc3 indicates that it:
  • participates in the following biological processes:
    • lipid catabolic process
    • lipid metabolic process
    • lipid transport
    • transport
  • is located in the following cellular components:
    • chylomicron
    • extracellular region
    • very-low-density lipoprotein particle

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References

1. Aalto-Setala K et al. (1996) Further characterization of the metabolic properties of triglyceride-rich lipoproteins from human and mouse apoC-III transgenic mice. J Lipid Res, 37:1802-11. (PubMed:8864964)
2. Hirano T et al. (2001) Apoprotein C-III deficiency markedly stimulates triglyceride secretion in vivo: comparison with apoprotein E. Am J Physiol Endocrinol Metab, 281:E665-9. (PubMed:11551841)
3. Jong MC et al. (2001) Apolipoprotein C-III deficiency accelerates triglyceride hydrolysis by lipoprotein lipase in wild-type and apoE knockout mice. J Lipid Res, 42:1578-85. (PubMed:11590213)
4. Maeda N et al. (1994) Targeted disruption of the apolipoprotein C-III gene in mice results in hypotriglyceridemia and protection from postprandial hypertriglyceridemia. J Biol Chem, 269:23610-6. (PubMed:8089130)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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