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Gene Ontology Classifications
Symbol
Name
ID
Apob
apolipoprotein B
MGI:88052

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Apob. (This text reflects annotations as of Thursday, July 24, 2014.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of January 25, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq


This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100. Unlike the apoB-48 and apoB-100 structural equivalents in human, which are synthesized exclusively in the gut and liver, respectively, the mouse apoB-48 isoform is also found in mouse liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2179 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Chen Z et al. (2004) Hepatic secretion of apoB-100 is impaired in hypobetalipoproteinemic mice with an apoB-38.9-specifying allele. J Lipid Res, 45:155-63. (PubMed:13130124)
  2. Chen Z et al. (2000) A targeted apolipoprotein B-38.9-producing mutation causes fatty livers in mice due to the reduced ability of apolipoprotein B-38.9 to transport triglycerides J Biol Chem, 275:32807-15. (PubMed:10893242)
  3. Farese RV Jr et al. (1995) Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotes. Proc Natl Acad Sci U S A, 92:1774-8. (PubMed:7878058)
  4. Homanics GE et al. (1993) Targeted modification of the apolipoprotein B gene results in hypobetalipoproteinemia and developmental abnormalities in mice. Proc Natl Acad Sci U S A, 90:2389-93. (PubMed:8460149)
  5. Huang LS et al. (1995) apo B gene knockout in mice results in embryonic lethality in homozygotes and neural tube defects, male infertility, and reduced HDL cholesterol ester and apo A-I transport rates in heterozygotes. J Clin Invest, 96:2152-61. (PubMed:7593600)
  6. Huang LS et al. (1996) A novel functional role for apolipoprotein B in male infertility in heterozygous apolipoprotein B knockout mice. Proc Natl Acad Sci U S A, 93:10903-7. (PubMed:8855280)
  7. Kim E et al. (1998) A gene-targeted mouse model for familial hypobetalipoproteinemia. Low levels of apolipoprotein B mRNA in association with a nonsense mutation in exon 26 of the apolipoprotein B gene. J Biol Chem, 273:33977-84. (PubMed:9852051)
  8. Kim E et al. (1998) Dual mechanisms for the low plasma levels of truncated apolipoprotein B proteins in familial hypobetalipoproteinemia. Analysis of a new mouse model with a nonsense mutation in the Apob gene. J Clin Invest, 101:1468-77. (PubMed:9502790)
  9. Kulinski A et al. (2002) Microsomal Triacylglycerol Transfer Protein Is Required for Lumenal Accretion of Triacylglycerol Not Associated with ApoB, as Well as for ApoB Lipidation. J Biol Chem, 277:31516-25. (PubMed:12072432)
  10. Lagor WR et al. (2012) The effects of apolipoprotein F deficiency on high density lipoprotein cholesterol metabolism in mice. PLoS One, 7:e31616. (PubMed:22363685)
  11. Leung GK et al. (2000) A deficiency of microsomal triglyceride transfer protein reduces apolipoprotein B secretion. J Biol Chem, 275:7515-20. (PubMed:10713055)
  12. Lin X et al. (2005) Reduced intestinal fat absorptive capacity but enhanced susceptibility to diet-induced fatty liver in mice heterozygous for ApoB38.9 truncation. Am J Physiol Gastrointest Liver Physiol, 289:G146-52. (PubMed:15790761)
  13. Lin X et al. (2006) A targeted apoB38.9 mutation in mice is associated with reduced hepatic cholesterol synthesis and enhanced lipid peroxidation. Am J Physiol Gastrointest Liver Physiol, 290:G1170-6. (PubMed:16455790)
  14. Srivastava RA et al. (1999) Regulation of the apolipoprotein B in heterozygous hypobetalipoproteinemic knock-out mice expressing truncated apoB, B81. Low production and enhanced clearance of apoB cause low levels of apoB. Mol Cell Biochem, 202:37-46. (PubMed:10705993)
  15. Tirziu D et al. (2005) Delayed arteriogenesis in hypercholesterolemic mice. Circulation, 112:2501-9. (PubMed:16230502)
  16. Toth LR et al. (1996) Two distinct apolipoprotein B alleles in mice generated by a single 'in-out' targeting. Gene, 178:161-8. (PubMed:8921909)
  17. Veniant MM et al. (1997) Susceptibility to atherosclerosis in mice expressing exclusively apolipoprotein B48 or apolipoprotein B100. J Clin Invest, 100:180-8. (PubMed:9202070)
  18. Veniant MM et al. (2000) Defining the atherogenicity of large and small lipoproteins containing apolipoprotein B100 J Clin Invest, 106:1501-10. (PubMed:11120757)
  19. Wu D et al. (2005) Heterozygous mutation of ataxia-telangiectasia mutated gene aggravates hypercholesterolemia in apoE-deficient mice. J Lipid Res, 46:1380-7. (PubMed:15863839)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory