Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Apoa4. (This text reflects annotations as of Thursday, July 24, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Apoa4
  • is located in the following cellular components:
    • extracellular space ^{[1, 2, 4]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Apoa4
  • participates in the following biological processes:
    • innate immune response in mucosa ^[3]
    • regulation of intestinal cholesterol absorption ^[5]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Apoa4:
  • participates in the following biological processes:
    • cholesterol efflux
    • cholesterol homeostasis
    • cholesterol metabolic process
    • hydrogen peroxide catabolic process
    • innate immune response in mucosa
    • leukocyte cell-cell adhesion
    • lipid homeostasis
    • lipid transport
    • multicellular organismal lipid catabolic process
    • negative regulation of plasma lipoprotein particle oxidation
    • phosphatidylcholine metabolic process
    • phospholipid efflux
    • positive regulation of cholesterol esterification
    • positive regulation of fatty acid biosynthetic process
    • positive regulation of lipoprotein lipase activity
    • positive regulation of triglyceride catabolic process
    • protein-lipid complex assembly
    • regulation of cholesterol transport
    • removal of superoxide radicals
    • response to lipid hydroperoxide
    • reverse cholesterol transport
    • very-low-density lipoprotein particle remodeling
  • performs the following molecular functions:
    • antioxidant activity
    • cholesterol transporter activity
    • copper ion binding
    • lipid binding
    • phosphatidylcholine binding
    • phosphatidylcholine-sterol O-acyltransferase activator activity
    • protein homodimerization activity
  • is located in the following cellular components:
    • blood microparticle
    • cell surface
    • chylomicron
    • extracellular space
    • extracellular vesicular exosome
    • high-density lipoprotein particle
    • very-low-density lipoprotein particle

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Summary text based on GO annotations supported by structural data

• Apoa4 encodes a protein or proteins that contain the following InterPro domains: Apolipoprotein A1/A4/E, indicating that the gene product:
  • participates in the following biological processes:
    • lipoprotein metabolic process
  • is located in the following cellular components:
    • extracellular region

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Apoa4 indicates that it:
  • participates in the following biological processes:
    • transport
  • is located in the following cellular components:
    • extracellular region

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References

1. Goodrum JF et al. (1995) Nerve regeneration and cholesterol reutilization occur in the absence of apolipoproteins E and A-I in mice. J Neurochem, 64:408-16. (PubMed:7798939)
2. Plump AS et al. (1997) ApoA-I knockout mice: characterization of HDL metabolism in homozygotes and identification of a post-RNA mechanism of apoA-I up-regulation in heterozygotes. J Lipid Res, 38:1033-47. (PubMed:9186920)
3. Vowinkel T et al. (2004) Apolipoprotein A-IV inhibits experimental colitis. J Clin Invest, 114:260-9. (PubMed:15254593)
4. Webb NR et al. (1997) Adenoviral vector-mediated overexpression of serum amyloid A in apoA-I-deficient mice. J Lipid Res, 38:1583-90. (PubMed:9300780)
5. Weinstock PH et al. (1997) Decreased HDL cholesterol levels but normal lipid absorption, growth, and feeding behavior in apolipoprotein A-IV knockout mice. J Lipid Res, 38:1782-94. (PubMed:9323588)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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