Automated description from the Alliance of Genome Resources (Release 3.0)
Exhibits several functions, including beta-catenin binding activity; dynein complex binding activity; and enzyme binding activity. Involved in several processes, including animal organ development; cell surface receptor signaling pathway; and regionalization. Localizes to several cellular components, including Scrib-APC-beta-catenin complex; axonal growth cone; and cell projection membrane. Colocalizes with cytoplasmic microtubule and microtubule plus-end. Used to study breast cancer; familial adenomatous polyposis; gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endometrial cancer (multiple); familial adenomatous polyposis 1; hereditary desmoid disease; and medulloblastoma. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; peripheral nervous system ganglion; and retina. Orthologous to human APC (APC regulator of WNT signaling pathway).