Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ang. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of December 14, 2007. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

---

Summary from NCBI RefSeq

This gene encodes a member of the pancreatic ribonuclease A superfamily and is a potent inducer of neovascularization. The encoded protein is a secreted multifunctional tRNA-specific ribonuclease that promotes angiogenesis in response to angiogenetic stimuli such as hypoxia, mediates stress-induced translational repression by cleaving cellular tRNAs, stimulates cell proliferation by mediating rRNA transcription in prostate cancer cells, and is involved in neurite pathfinding. This gene resides in a cluster of highly related genes. It shares dual promoters and 5' exons with the ribonuclease, RNase A family 4 gene. Two alternatively spliced variants, with different 5' exons but the same coding exon, have been identified. Multiple pseudogenes have been found for this gene. [provided by RefSeq, Jun 2009]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Ang
  • performs the following molecular functions:
    • ribonuclease activity ^[1]
  • is located in the following cellular components:
    • growth cone ^[2]
    • neuronal cell body ^[2]
• Based on the experimental annotations above, MGI curators have inferred, that the gene product of Ang
  • performs the following molecular functions:
    • RNA binding ^[1]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Ang:
  • participates in the following biological processes:
    • activation of phospholipase A2 activity
    • activation of phospholipase C activity
    • activation of protein kinase B activity
    • angiogenesis
    • cell migration
    • diacylglycerol biosynthetic process
    • negative regulation of smooth muscle cell proliferation
    • positive regulation of endothelial cell proliferation
    • positive regulation of phosphorylation
    • positive regulation of protein secretion
    • response to hormone stimulus
    • response to hypoxia
    • rRNA transcription
  • performs the following molecular functions:
    • actin binding
    • copper ion binding
    • heparin binding
    • peptide binding
    • receptor binding
    • ribonuclease activity
  • is located in the following cellular components:
    • angiogenin-PRI complex
    • basal lamina
    • extracellular space
    • nucleus

---

Summary text based on GO annotations supported by structural data

• Ang encodes a protein or proteins that contain the following InterPro domains: Ribonuclease A, Ribonuclease A, active site, Ribonuclease A, domain, indicating that the gene product:
  • performs the following molecular functions:
    • nucleic acid binding
    • pancreatic ribonuclease activity

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ang indicates that it:
  • participates in the following biological processes:
    • cell differentiation
    • multicellular organismal development
    • negative regulation of translation
  • performs the following molecular functions:
    • endonuclease activity
    • hydrolase activity
    • nuclease activity
  • is located in the following cellular components:
    • extracellular region

---

References

1. Bond MD et al. (1993) Characterization and sequencing of rabbit, pig and mouse angiogenins: discernment of functionally important residues and regions. Biochim Biophys Acta, 1162:177-86. (PubMed:8448182)
2. Subramanian V et al. (2007) A new role for angiogenin in neurite growth and pathfinding: implications for amyotrophic lateral sclerosis. Hum Mol Genet, 16:1445-53. (PubMed:17468498)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---