Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Mat1a. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Mat1a:
  • participates in the following biological processes:
    • protein homooligomerization
    • protein homotetramerization
    • S-adenosylmethionine biosynthetic process
  • performs the following molecular functions:
    • ADP binding
    • amino acid binding
    • ATP binding
    • identical protein binding
    • magnesium ion binding
    • methionine adenosyltransferase activity
    • protein homodimerization activity

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Summary text based on GO annotations supported by structural data

• Mat1a encodes a protein or proteins that contain the following InterPro domains: S-adenosylmethionine synthetase, S-adenosylmethionine synthetase superfamily, S-adenosylmethionine synthetase, C-terminal, S-adenosylmethionine synthetase, central domain, S-adenosylmethionine synthetase, conserved site, S-adenosylmethionine synthetase, N-terminal, indicating that the gene product:
  • participates in the following biological processes:
    • methanogenesis

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Mat1a indicates that it:
  • participates in the following biological processes:
    • one-carbon metabolic process
  • performs the following molecular functions:
    • metal ion binding
    • nucleotide binding
    • transferase activity

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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