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Gene Ontology Classifications
thymoma viral proto-oncogene 1

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Akt1. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

This gene encodes the founding member of the Akt serine-threonine protein kinase gene family that also includes Akt2 and Akt3. This kinase is a major downstream effector of the phosphatidylinositol 3-kinase (PI3K) pathway that mediates the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). It is activated through recruitment to cellular membranes by PI3K lipid products and by phosphorylation by 3-phosphoinositide dependent kinase-1. It then further phosphorylates different downstream proteins in response to various extracellular signals and thus plays a pivotal role in mediating a variety of cellular processes, such as glucose metabolism, glycogen biosynthesis, protein synthesis and turn over, inflammatory response, cell survival (anti-apoptosis) and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Anai M et al. (2005) A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis. J Biol Chem, 280:18525-35. (PubMed:15753085)
  2. Auger R et al. (2005) A role for mitogen-activated protein kinase(Erk1/2) activation and non-selective pore formation in P2X7 receptor-mediated thymocyte death. J Biol Chem, 280:28142-51. (PubMed:15937334)
  3. Baki L et al. (2004) PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations. EMBO J, 23:2586-96. (PubMed:15192701)
  4. Beaulieu JM et al. (2005) An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. Cell, 122:261-73. (PubMed:16051150)
  5. Campbell PA et al. (2013) Oct4 interaction with hmgb2 regulates akt signaling and pluripotency. Stem Cells, 31:1107-20. (PubMed:23495099)
  6. Cariaga-Martinez AE et al. (2014) Phosphoinositide 3-kinase p85beta regulates invadopodium formation. Biol Open, 3:924-36. (PubMed:25217619)
  7. Cong LN et al. (1997) Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells. Mol Endocrinol, 11:1881-90. (PubMed:9415393)
  8. Cotter L et al. (2010) Dlg1-PTEN interaction regulates myelin thickness to prevent damaging peripheral nerve overmyelination. Science, 328:1415-8. (PubMed:20448149)
  9. De Miguel MP et al. (2002) Dissection of the c-Kit signaling pathway in mouse primordial germ cells by retroviral-mediated gene transfer. Proc Natl Acad Sci U S A, 99:10458-63. (PubMed:12140361)
  10. Di-Poi N et al. (2005) Epithelium-mesenchyme interactions control the activity of peroxisome proliferator-activated receptor beta/delta during hair follicle development. Mol Cell Biol, 25:1696-712. (PubMed:15713628)
  11. Ding J et al. (2009) ClipR-59 interacts with Akt and regulates Akt cellular compartmentalization. Mol Cell Biol, 29:1459-71. (PubMed:19139280)
  12. Du K et al. (2003) TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. Science, 300:1574-7. (PubMed:12791994)
  13. Facchinetti V et al. (2008) The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J, 27:1932-43. (PubMed:18566586)
  14. Festuccia WT et al. (2014) Myeloid-specific Rictor deletion induces M1 macrophage polarization and potentiates in vivo pro-inflammatory response to lipopolysaccharide. PLoS One, 9:e95432. (PubMed:24740015)
  15. Fisher D et al. (2011) Leukocyte Common Antigen-Related Phosphatase Is a Functional Receptor for Chondroitin Sulfate Proteoglycan Axon Growth Inhibitors. J Neurosci, 31:14051-14066. (PubMed:21976490)
  16. Fox CJ et al. (2003) The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor. Genes Dev, 17:1841-54. (PubMed:12869584)
  17. Fuentes-Calvo I et al. (2013) The small GTPase N-Ras regulates extracellular matrix synthesis, proliferation and migration in fibroblasts. Biochim Biophys Acta, 1833:2734-44. (PubMed:23871832)
  18. Fukasaka M et al. (2013) Critical role of AZI2 in GM-CSF-induced dendritic cell differentiation. J Immunol, 190:5702-11. (PubMed:23610142)
  19. Galic M et al. (2012) External push and internal pull forces recruit curvature-sensing N-BAR domain proteins to the plasma membrane. Nat Cell Biol, 14:874-81. (PubMed:22750946)
  20. Giorgi C et al. (2010) PML regulates apoptosis at endoplasmic reticulum by modulating calcium release. Science, 330:1247-51. (PubMed:21030605)
  21. Giovannone B et al. (2009) GIGYF2 gene disruption in mice results in neurodegeneration and altered insulin-like growth factor signaling. Hum Mol Genet, 18:4629-39. (PubMed:19744960)
  22. Gleason CE et al. (2009) Role of Insulin-Like Growth Factor-Binding Protein 5 (IGFBP5) in Organismal and Pancreatic {beta}-Cell Growth. Mol Endocrinol, null:null. (PubMed:19897600)
  23. Gotz R et al. (2005) Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells. Nat Neurosci, 8:1169-78. (PubMed:16116448)
  24. Haddad G et al. (2014) Phosphoinositide 3-kinase beta mediates microvascular endothelial repair of thrombotic microangiopathy. Blood, 124:2142-9. (PubMed:25139353)
  25. Harrington LS et al. (2004) The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J Cell Biol, 166:213-23. (PubMed:15249583)
  26. Hauge H et al. (2009) Evidence for the involvement of FAM110C protein in cell spreading and migration. Cell Signal, 21:1866-73. (PubMed:19698782)
  27. Khattar E et al. (2012) Akt augments the oncogenic potential of the HBx protein of hepatitis B virus by phosphorylation. FEBS J, 279:1220-30. (PubMed:22309289)
  28. Kim EK et al. (2011) Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis. Oncogene, 30:2954-63. (PubMed:21339740)
  29. Kim JY et al. (2009) DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212. Neuron, 63:761-73. (PubMed:19778506)
  30. Lee IH et al. (2007) Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2. J Biol Chem, 282:29866-73. (PubMed:17715136)
  31. Li W et al. (2014) PTEN degradation after ischemic stroke: a double-edged sword. Neuroscience, 274:153-61. (PubMed:24875179)
  32. Liang Y et al. (2013) The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells. Nat Immunol, 14:858-66. (PubMed:23793062)
  33. Lin HK et al. (2002) Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase. EMBO J, 21:4037-48. (PubMed:12145204)
  34. Lin ST et al. (2013) MicroRNA-23a promotes myelination in the central nervous system. Proc Natl Acad Sci U S A, 110:17468-73. (PubMed:24101522)
  35. Liu J et al. (2004) Serine-threonine kinases and transcription factors active in signal transduction are detected at high levels of phosphorylation during mitosis in preimplantation embryos and trophoblast stem cells. Reproduction, 128:643-654. (PubMed:15509711)
  36. Luque RM et al. (2006) Impact of obesity on the growth hormone axis: evidence for a direct inhibitory effect of hyperinsulinemia on pituitary function. Endocrinology, 147:2754-63. (PubMed:16513828)
  37. Mahajan K et al. (2010) Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation. PLoS One, 5:e9646. (PubMed:20333297)
  38. Mukherjee A et al. (2009) Akt promotes BMP2-mediated osteoblast differentiation and bone development. J Cell Sci, 122:716-26. (PubMed:19208758)
  39. Nawa M et al. (2008) A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB. Cell Signal, 20:493-505. (PubMed:18160256)
  40. Nawa M et al. (2013) KCTD20, a relative of BTBD10, is a positive regulator of Akt. BMC Biochem, 14:27. (PubMed:24156551)
  41. Palamarchuk A et al. (2005) Akt phosphorylates and regulates Pdcd4 tumor suppressor protein. Cancer Res, 65:11282-6. (PubMed:16357133)
  42. Rahman P et al. (2011) Silencer of death domains (SODD) inhibits skeletal muscle and kidney enriched inositol 5-phosphatase (SKIP) and regulates phosphoinositide 3-kinase (PI3K)/Akt signaling to the actin cytoskeleton. J Biol Chem, 286:29758-70. (PubMed:21712384)
  43. Ren H et al. (2008) IGFBP-5 regulates muscle cell differentiation by binding to IGF-II and switching on the IGF-II auto-regulation loop. J Cell Biol, 182:979-91. (PubMed:18762576)
  44. Song J et al. (2004) The costimulation-regulated duration of PKB activation controls T cell longevity. Nat Immunol, 5:150-8. (PubMed:14730361)
  45. Sun X et al. (2008) Akt activation prevents Apop-1-induced death of cells. Biochem Biophys Res Commun, 377:1097-101. (PubMed:18977203)
  46. Traves PG et al. (2013) Selective Impairment of P2Y Signaling by Prostaglandin E2 in Macrophages: Implications for Ca2+-Dependent Responses. J Immunol, 190:4226-35. (PubMed:23479225)
  47. Tuhackova Z et al. (2004) IL2-dependent phosphorylation of 40S ribosomal protein S6 is controlled by PI-3K/mTOR signalling in CTLL2 cells. Int J Mol Med, 13:601-5. (PubMed:15010863)
  48. Tunggal JA et al. (2005) E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J, 24:1146-56. (PubMed:15775979)
  49. Urschel S et al. (2005) Phosphorylation of grb10 regulates its interaction with 14-3-3. J Biol Chem, 280:16987-93. (PubMed:15722337)
  50. Wakatsuki S et al. (2011) ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation. Nat Cell Biol, 13:1415-23. (PubMed:22057101)
  51. Wu X et al. (2006) Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin. Genes Dev, 20:571-85. (PubMed:16510873)
  52. Xu J et al. (2002) The role of Asp-462 in regulating Akt activity. J Biol Chem, 277:35561-6. (PubMed:12124386)
  53. Yamashita K et al. (2001) Reperfusion-activated Akt kinase prevents apoptosis in transgenic mouse hearts overexpressing insulin-like growth factor-1. Circ Res, 88:609-14. (PubMed:11282895)
  54. Yang ZZ et al. (2003) Protein kinase B alpha/Akt1 regulates placental development and fetal growth. J Biol Chem, 278:32124-31. (PubMed:12783884)
  55. Yasui T et al. (2012) Protein kinase N1, a cell inhibitor of Akt kinase, has a central role in quality control of germinal center formation. Proc Natl Acad Sci U S A, 109:21022-7. (PubMed:23223530)
  56. Zhu D et al. (2009) Growth arrest induces primary-cilium formation and sensitizes IGF-1-receptor signaling during differentiation induction of 3T3-L1 preadipocytes. J Cell Sci, 122:2760-8. (PubMed:19596798)

Go Annotations in Tabular Form (Text View) (GO Graph)

Filter Markers by: Category  Evidence Code 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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