Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ak1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Adenylate kinase is an enzyme involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate group among adinine nucleotides. Three isozymes of adenylate kinase have been identified in vertebrates, adenylate isozyme 1 (AK1), 2 (AK2) and 3 (AK3). AK1 is found in the cytosol of skeletal muscle, brain and erythrocytes, whereas AK2 and AK3 are found in the mitochondria of other tissues including liver and heart. AK1 was identified because of its association with a rare genetic disorder causing nonspherocytic hemolytic anemia where a mutation in the AK1 gene was found to reduce the catalytic activity of the enzyme. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Ak1
  • participates in the following biological processes:
    • cell cycle arrest ^[2]
    • nucleotide phosphorylation ^{[3, 4, 5]}
  • performs the following molecular functions:
    • adenylate kinase activity ^{[3, 4, 5]}
  • is located in the following cellular components:
    • cytoplasm ^[2]
    • outer dense fiber ^[1]
    • plasma membrane ^[2]
    • sperm flagellum ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Ak1:
  • participates in the following biological processes:
    • ADP biosynthetic process
    • AMP metabolic process
    • inosine biosynthetic process
    • positive regulation of glucose transport
  • performs the following molecular functions:
    • adenylate kinase activity
    • phosphotransferase activity, phosphate group as acceptor
  • is located in the following cellular components:
    • cytoplasm
    • neuron projection
    • perinuclear region of cytoplasm
    • sarcomere

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Summary text based on GO annotations supported by structural data

• Ak1 encodes a protein or proteins that contain the following InterPro domains: Adenylate kinase, Adenylate kinase, isozyme 1, indicating that the gene product:
  • participates in the following biological processes:
    • ATP metabolic process
    • nucleobase-containing compound metabolic process
  • performs the following molecular functions:
    • ATP binding
    • nucleobase-containing compound kinase activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ak1 indicates that it:
  • participates in the following biological processes:
    • phosphorylation
  • performs the following molecular functions:
    • ATP binding
    • kinase activity
    • nucleotide binding
    • transferase activity

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References

1. Cao W et al. (2006) Adenylate kinases 1 and 2 are part of the accessory structures in the mouse sperm flagellum. Biol Reprod, 75:492-500. (PubMed:16790685)
2. Collavin L et al. (1999) wt p53 dependent expression of a membrane-associated isoform of adenylate kinase. Oncogene, 18:5879-88. (PubMed:10557075)
3. Francke U et al. (1977) Gene mapping in Mus musculus by interspecific cell hybridization: assignment of the genes for tripeptidase-1 to chromosome 10, dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome 12, and adenylate kinase-1 to chromosome 2. Cytogenet Cell Genet, 19:57-84. (PubMed:198184)
4. Schafer R et al. (1980) Assignment of the gene for cytoplasmic glutamate-oxaloacetate transaminase to mouse chromosome 19 using chinese hamster x mouse somatic cell hybrids. Somatic Cell Genet, 6:709-17. (PubMed:7444718)
5. Stallings RL et al. (1981) Confirmational, provisional, and/or regional assignment of 15 enzyme loci onto Chinese hamster autosomes 1, 2, and 7. Somatic Cell Genet, 7:683-98. (PubMed:7323947)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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