Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Agtr1b. (This text reflects annotations as of Thursday, July 24, 2014.)

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Agtr1b
  • participates in the following biological processes:
    • drinking behavior ^[1]
• Researchers have inferred, based on genetic interactions, that the gene product of Agtr1b
  • participates in the following biological processes:
    • blood vessel development based on interactions with Agtr1a ^[3]
    • drinking behavior based on interactions with Agtr1a ^[1]
    • inflammatory response based on interactions with Agtr1a, Agtr2 ^[2]
    • kidney development based on interactions with Agtr1b ^[3]
    • regulation of systemic arterial blood pressure by circulatory renin-angiotensin based on interactions with Agtr1a ^[3]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Agtr1b:
  • participates in the following biological processes:
    • cellular response to dexamethasone stimulus
    • G-protein coupled receptor signaling pathway
    • phospholipase C-activating angiotensin-activated signaling pathway
    • positive regulation of branching involved in ureteric bud morphogenesis
    • positive regulation of cytosolic calcium ion concentration
    • response to estrogen
  • performs the following molecular functions:
    • angiotensin type I receptor activity
    • peptide hormone binding
    • protein self-association
  • is located in the following cellular components:
    • basolateral plasma membrane
    • vesicle lumen
    • vesicle membrane

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Summary text based on GO annotations supported by structural data

• Agtr1b encodes a protein or proteins that contain the following InterPro domains: Angiotensin II receptor family, Angiotensin II receptor type 1, G protein-coupled receptor, rhodopsin-like, GPCR, rhodopsin-like, 7TM, indicating that the gene product:
  • participates in the following biological processes:
    • regulation of vasoconstriction
  • performs the following molecular functions:
    • angiotensin type II receptor activity
    • G-protein coupled receptor activity
  • is located in the following cellular components:
    • integral component of membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Agtr1b indicates that it:
  • participates in the following biological processes:
    • signal transduction
  • performs the following molecular functions:
    • G-protein coupled receptor activity
    • signal transducer activity
  • is located in the following cellular components:
    • integral component of membrane
    • membrane
    • plasma membrane

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References

1. Davisson RL et al. (2000) Divergent functions of angiotensin II receptor isoforms in the brain. J Clin Invest, 106:103-6. (PubMed:10880053)
2. Esteban V et al. (2009) Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammation. PLoS ONE, 4:e5406. (PubMed:19404405)
3. Tsuchida S et al. (1998) Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes. J Clin Invest, 101:755-60. (PubMed:9466969)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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