Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Agtr1b. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Agtr1b
  • participates in the following biological processes:
    • drinking behavior ^[1]
• Researchers have inferred, based on genetic interactions, that the gene product of Agtr1b
  • participates in the following biological processes:
    • blood vessel development based on interactions with Agtr1a ^[3]
    • drinking behavior based on interactions with Agtr1a ^[1]
    • inflammatory response based on interactions with Agtr1a, Agtr2 ^[2]
    • kidney development based on interactions with Agtr1b ^[3]
    • regulation of systemic arterial blood pressure by circulatory renin-angiotensin based on interactions with Agtr1a ^[3]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Agtr1b:
  • participates in the following biological processes:
    • calcium-mediated signaling
    • cell chemotaxis
    • cellular response to dexamethasone stimulus
    • elevation of cytosolic calcium ion concentration
    • elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
    • G-protein coupled receptor signaling pathway
    • kidney development
    • phospholipase C-activating angiotensin-mediated signaling pathway
    • positive regulation of branching involved in ureteric bud morphogenesis
    • positive regulation of cellular protein metabolic process
    • positive regulation of cholesterol esterification
    • positive regulation of phospholipase A2 activity
    • regulation of vasoconstriction
    • response to estrogen stimulus
    • Rho protein signal transduction
  • performs the following molecular functions:
    • acetyltransferase activator activity
    • angiotensin type I receptor activity
    • angiotensin type II receptor activity
    • bradykinin receptor binding
    • peptide hormone binding
    • protein heterodimerization activity
    • protein self-association
  • is located in the following cellular components:
    • basolateral plasma membrane
    • plasma membrane
    • vesicle lumen
    • vesicle membrane

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Summary text based on GO annotations supported by structural data

• Agtr1b encodes a protein or proteins that contain the following InterPro domains: Angiotensin II receptor, AT1 angiotensin II receptor, GPCR, rhodopsin-like, GPCR, rhodopsin-like, 7TM, indicating that the gene product:
  • is located in the following cellular components:
    • integral to membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Agtr1b indicates that it:
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway
    • signal transduction
  • performs the following molecular functions:
    • G-protein coupled receptor activity
    • signal transducer activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Davisson RL et al. (2000) Divergent functions of angiotensin II receptor isoforms in the brain. J Clin Invest, 106:103-6. (PubMed:10880053)
2. Esteban V et al. (2009) Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammation. PLoS ONE, 4:e5406. (PubMed:19404405)
3. Tsuchida S et al. (1998) Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes. J Clin Invest, 101:755-60. (PubMed:9466969)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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