Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Adrb3. (This text reflects annotations as of Wednesday, January 23, 2013.)

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. [provided by RefSeq, Feb 2009]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Adrb3
  • participates in the following biological processes:
    • adenylate cyclase-activating G-protein coupled receptor signaling pathway ^[4]
    • vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure ^[5]
  • performs the following molecular functions:
    • beta-3 adrenergic receptor binding ^{[2, 4]}
  • is located in the following cellular components:
    • membrane ^[4]
• Researchers have inferred, based on genetic interactions, that the gene product of Adrb3
  • participates in the following biological processes:
    • brown fat cell differentiation based on interactions with Adrb1, Adrb2 ^[3]
    • diet induced thermogenesis based on interactions with Adrb1, Adrb2 ^[1]
    • heat generation based on interactions with Adrb1, Adrb2 ^[1]
    • negative regulation of multicellular organism growth based on interactions with Adrb1, Adrb2 ^[3]
    • response to cold based on interactions with Adrb1, Adrb2 ^{[1, 3]}

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Adrb3:
  • participates in the following biological processes:
    • activation of adenylate cyclase activity
    • adenylate cyclase-activating G-protein coupled receptor signaling pathway
    • eating behavior
    • positive regulation of MAPK cascade
  • performs the following molecular functions:
    • beta-adrenergic receptor activity
    • beta3-adrenergic receptor activity
    • epinephrine binding
    • norepinephrine binding
    • protein homodimerization activity
  • is located in the following cellular components:
    • nucleus
    • receptor complex

---

Summary text based on GO annotations supported by structural data

• Adrb3 encodes a protein or proteins that contain the following InterPro domains: Adrenergic receptor, Adrenergic receptor, beta 3, GPCR, rhodopsin-like, GPCR, rhodopsin-like, 7TM, indicating that the gene product:
  • participates in the following biological processes:
    • adrenergic receptor signaling pathway
    • G-protein coupled receptor signaling pathway
  • performs the following molecular functions:
    • adrenergic receptor activity
  • is located in the following cellular components:
    • integral to membrane

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Adrb3 indicates that it:
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway
    • signal transduction
  • performs the following molecular functions:
    • G-protein coupled receptor activity
    • signal transducer activity
  • is located in the following cellular components:
    • integral to membrane
    • plasma membrane

---

References

1. Bachman ES et al. (2002) betaAR signaling required for diet-induced thermogenesis and obesity resistance. Science, 297:843-5. (PubMed:12161655)
2. Hadri KE et al. (1997) Differential regulation by tumor necrosis factor-alpha of beta1-, beta2-, and beta3-adrenoreceptor gene expression in 3T3-F442A adipocytes. J Biol Chem, 272:24514-21. (PubMed:9305915)
3. Jimenez M et al. (2002) beta(1)/beta(2)/beta(3)-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting. FEBS Lett, 530:37. (PubMed:12387862)
4. Rohlfs EM et al. (1995) Regulation of the uncoupling protein gene (Ucp) by beta 1, beta 2, and beta 3-adrenergic receptor subtypes in immortalized brown adipose cell lines. J Biol Chem, 270:10723-32. (PubMed:7738011)
5. Rohrer DK et al. (1999) Cardiovascular and metabolic alterations in mice lacking both beta1- and beta2-adrenergic receptors. J Biol Chem, 274:16701-8. (PubMed:10358009)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---