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Gene Ontology Classifications
adrenergic receptor, beta 2

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GO curators for mouse genes have assigned the following annotations to the gene product of Adrb2. (This text reflects annotations as of Tuesday, May 26, 2015.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of December 28, 2005. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq

This intronless gene belongs to the G-protein-coupled receptor superfamily, which includes transmembrane proteins that play a role in signal transduction across biological membranes resulting in a variety of physiological responses. The encoded protein is a beta-2 adrenergic receptor which is activated by catecholamine ligands such as adrenaline and epinephrine. The protein participates in the classical signaling pathway involving G protein, adenylyl cyclase, cAMP (3'-5'-cyclic adenosine monophosphate) and protein kinase A (PKA). In humans, this gene is implicated in susceptibility to nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Apr 2013]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Allen JM et al. (1988) Isoproterenol response following transfection of the mouse beta 2-adrenergic receptor gene into Y1 cells. EMBO J, 7:133-8. (PubMed:2834198)
  2. Bachman ES et al. (2002) betaAR signaling required for diet-induced thermogenesis and obesity resistance. Science, 297:843-5. (PubMed:12161655)
  3. Chruscinski A et al. (2001) Differential distribution of beta-adrenergic receptor subtypes in blood vessels of knockout mice lacking beta(1)- or beta(2)-adrenergic receptors. Mol Pharmacol, 60:955-62. (PubMed:11641423)
  4. Chruscinski AJ et al. (1999) Targeted disruption of the beta2 adrenergic receptor gene. J Biol Chem, 274:16694-700. (PubMed:10358008)
  5. Cikos S et al. (2005) Expression of beta adrenergic receptors in mouse oocytes and preimplantation embryos. Mol Reprod Dev, 71:145-53. (PubMed:15791602)
  6. De Arcangelis V et al. (2009) Differential association of phosphodiesterase 4D isoforms with beta2-adrenoceptor in cardiac myocytes. J Biol Chem, 284:33824-32. (PubMed:19801680)
  7. Elefteriou F et al. (2005) Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature, 434:514-20. (PubMed:15724149)
  8. Hadri KE et al. (1997) Differential regulation by tumor necrosis factor-alpha of beta1-, beta2-, and beta3-adrenoreceptor gene expression in 3T3-F442A adipocytes. J Biol Chem, 272:24514-21. (PubMed:9305915)
  9. Huang T et al. (2003) Foxj1 is required for apical localization of ezrin in airway epithelial cells. J Cell Sci, 116:4935-45. (PubMed:14625387)
  10. Jimenez M et al. (2002) beta(1)/beta(2)/beta(3)-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting. FEBS Lett, 530:37. (PubMed:12387862)
  11. Klein U et al. (1997) A novel interaction between adrenergic receptors and the alpha-subunit of eukaryotic initiation factor 2B. J Biol Chem, 272:19099-102. (PubMed:9235896)
  12. Lavine N et al. (2002) G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase. J Biol Chem, 277:46010-9. (PubMed:12297500)
  13. Markovac J et al. (1983) Genetic variation in beta-adrenergic receptors in mice: a magnesium effect determined by a single gene. Genet Res, 42:159-68. (PubMed:6321299)
  14. McGraw DW et al. (2001) Targeted transgenic expression of beta(2)-adrenergic receptors to type II cells increases alveolar fluid clearance. Am J Physiol Lung Cell Mol Physiol, 281:L895-903. (PubMed:11557593)
  15. McGraw DW et al. (2003) Antithetic regulation by beta-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway beta-agonist paradox. J Clin Invest, 112:619-26. (PubMed:12925702)
  16. Mutlu GM et al. (2004) Upregulation of alveolar epithelial active Na+ transport is dependent on beta2-adrenergic receptor signaling. Circ Res, 94:1091-100. (PubMed:15016730)
  17. Rohlfs EM et al. (1995) Regulation of the uncoupling protein gene (Ucp) by beta 1, beta 2, and beta 3-adrenergic receptor subtypes in immortalized brown adipose cell lines. J Biol Chem, 270:10723-32. (PubMed:7738011)
  18. Rohrer DK et al. (1996) Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects. Proc Natl Acad Sci U S A, 93:7375-80. (PubMed:8693001)
  19. Rohrer DK et al. (1999) Cardiovascular and metabolic alterations in mice lacking both beta1- and beta2-adrenergic receptors. J Biol Chem, 274:16701-8. (PubMed:10358009)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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