Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Adra2c. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Adra2c
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway ^[1]
  • performs the following molecular functions:
    • G-protein coupled receptor activity ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Adra2c:
  • participates in the following biological processes:
    • activation of MAPK activity by adrenergic receptor signaling pathway
    • activation of protein kinase B activity
    • epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
    • female pregnancy
    • negative regulation of uterine smooth muscle contraction
    • positive regulation of neuron differentiation
    • positive regulation of vasoconstriction
    • regulation of sensory perception of pain
  • performs the following molecular functions:
    • alpha-2A adrenergic receptor binding
    • alpha2-adrenergic receptor activity
    • epinephrine binding
    • protein heterodimerization activity
    • protein homodimerization activity
  • is located in the following cellular components:
    • axon
    • axon terminus
    • cytoplasm
    • integral to plasma membrane

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Summary text based on GO annotations supported by structural data

• Adra2c encodes a protein or proteins that contain the following InterPro domains: Adrenergic receptor, Adrenergic receptor, alpha-2C, GPCR, rhodopsin-like, GPCR, rhodopsin-like, 7TM, indicating that the gene product:
  • performs the following molecular functions:
    • adrenergic receptor activity
  • is located in the following cellular components:
    • integral to membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Adra2c indicates that it:
  • participates in the following biological processes:
    • signal transduction
  • performs the following molecular functions:
    • signal transducer activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane
    • plasma membrane

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References

1. Weissman JT et al. (2004) G-protein-coupled receptor-mediated activation of rap GTPases: characterization of a novel Galphai regulated pathway. Oncogene, 23:241-9. (PubMed:14712229)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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