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Gene Ontology Classifications
alcohol dehydrogenase 1 (class I)

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Adh1. (This text reflects annotations as of Tuesday, May 26, 2015.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of September 10, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Algar EM et al. (1985) Mouse mitochondrial aldehyde dehydrogenase isozymes: purification and molecular properties. Int J Biochem, 17:51-60. (PubMed:3996732)
  2. Asadi FK et al. (1994) Androgen regulation of gene expression in primary epithelial cells of the mouse kidney. Endocrinology, 134:1179-87. (PubMed:8119157)
  3. Balak KJ et al. (1982) Genetic and developmental regulation of mouse liver alcohol dehydrogenase. J Biol Chem, 257:15000-7. (PubMed:6816803)
  4. Deltour L et al. (1997) Localization of class I and class IV alcohol dehydrogenases in mouse testis and epididymis: potential retinol dehydrogenases for endogenous retinoic acid synthesis. Biol Reprod, 56:102-9. (PubMed:9002638)
  5. Deltour L et al. (1999) Metabolic deficiencies in alcohol dehydrogenase Adh1, Adh3, and Adh4 null mutant mice. Overlapping roles of Adh1 and Adh4 in ethanol clearance and metabolism of retinol to retinoic acid. J Biol Chem, 274:16796-801. (PubMed:10358022)
  6. Holmes RS. (1979) Genetics and ontogeny of alcohol dehydrogenase isozymes in the mouse: evidence for a cis-acting regulator gene (Adt-i) controlling C2 isozyme expression in reproductive tissues and close linkage of Adh-3 and Adt-i on chromosome 3. Biochem Genet, 17:461-72. (PubMed:518534)
  7. Holmes RS et al. (1981) Mouse alcohol dehydrogenase isozymes: products of closely localized duplicate genes exhibiting divergent kinetic properties. J Exp Zool, 217:151-7. (PubMed:7026729)
  8. Molotkov A et al. (2002) Excessive vitamin A toxicity in mice genetically deficient in either alcohol dehydrogenase Adh1 or Adh3. Eur J Biochem, 269:2607-12. (PubMed:12027900)
  9. Molotkov A et al. (2003) Genetic evidence that retinaldehyde dehydrogenase Raldh1 (Aldh1a1) functions downstream of alcohol dehydrogenase Adh1 in metabolism of retinol to retinoic acid. J Biol Chem, 278:36085-90. (PubMed:12851412)
  10. Molotkov A et al. (2004) Opposing actions of cellular retinol-binding protein and alcohol dehydrogenase control the balance between retinol storage and degradation. Biochem J, 383:295-302. (PubMed:15193143)
  11. Rex DK et al. (1984) Purification and characterization of mouse alcohol dehydrogenase from two inbred strains that differ in total liver enzyme activity. Biochem Genet, 22:115-24. (PubMed:6370228)
  12. Shean ML et al. (1993) The role of alcohol dehydrogenase in retinoic acid homeostasis and fetal alcohol syndrome. Alcohol Alcohol Suppl, 2:51-6. (PubMed:7748347)
  13. Xie D et al. (1996) Ten kilobases of 5'-flanking region confers proper regulation of the mouse alcohol dehydrogenase-1 (Adh-1) gene in kidney and adrenal of transgenic mice. Gene, 181:173-8. (PubMed:8973327)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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