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Gene Ontology Classifications
adenosine deaminase

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ada. (This text reflects annotations as of Tuesday, May 26, 2015.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of January 26, 2009. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been described for this gene and have been linked to human diseases. Deficiency in this enzyme causes a form of severe combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production of immunoglobulins, whereas elevated levels of this enzyme have been associated with congenital hemolytic anemia. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. al-Ubaidi MR et al. (1990) Structural and functional analysis of the murine adenosine deaminase gene. Genomics, 7:476-85. (PubMed:2387582)
  2. Aldrich MB et al. (2003) Impaired germinal center maturation in adenosine deaminase deficiency. J Immunol, 171:5562-70. (PubMed:14607964)
  3. Apasov S et al. (2000) A(2A) receptor dependent and A(2A) receptor independent effects of extracellular adenosine on murine thymocytes in conditions of adenosine deaminase deficiency Blood, 95:3859-67. (PubMed:10845921)
  4. Apasov SG et al. (2001) Adenosine deaminase deficiency increases thymic apoptosis and causes defective T cell receptor signaling. J Clin Invest, 108:131-41. (PubMed:11435465)
  5. Blackburn MR et al. (2000) Metabolic consequences of adenosine deaminase deficiency in mice are associated with defects in alveogenesis, pulmonary inflammation, and airway obstruction J Exp Med, 192:159-70. (PubMed:10899903)
  6. Blackburn MR et al. (1998) Adenosine deaminase-deficient mice generated using a two-stage genetic engineering strategy exhibit a combined immunodeficiency. J Biol Chem, 273:5093-100. (PubMed:9478961)
  7. Blackburn MR et al. (1995) Tissue-specific rescue suggests that placental adenosine deaminase is important for fetal development in mice. J Biol Chem, 270:23891-4. (PubMed:7592575)
  8. Blackburn MR et al. (1996) Metabolic and immunologic consequences of limited adenosine deaminase expression in mice. J Biol Chem, 271:15203-10. (PubMed:8663040)
  9. Blackburn MR et al. (1997) Genetically engineered mice demonstrate that adenosine deaminase is essential for early postimplantation development. Development, 124:3089-97. (PubMed:9272950)
  10. Bodine DM et al. (1993) Long-term in vivo expression of a murine adenosine deaminase gene in rhesus monkey hematopoietic cells of multiple lineages after retroviral mediated gene transfer into CD34+ bone marrow cells. Blood, 82:1975-80. (PubMed:7691243)
  11. Chunn JL et al. (2001) Adenosine-dependent airway inflammation and hyperresponsiveness in partially adenosine deaminase-deficient mice. J Immunol, 167:4676-85. (PubMed:11591798)
  12. Gao X et al. (1994) Activation of apoptosis in early mouse embryos by 2'-deoxyadenosine exposure. Teratology, 49:1-12. (PubMed:8171392)
  13. Jinnah HA et al. (1993) Brain purines in a genetic mouse model of Lesch-Nyhan disease. J Neurochem, 60:2036-45. (PubMed:8492116)
  14. Knudsen TB et al. (1991) Ontogeny of adenosine deaminase in the mouse decidua and placenta: immunolocalization and embryo transfer studies. Biol Reprod, 44:171-84. (PubMed:2015347)
  15. Mi T et al. (2008) Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling. J Clin Invest, 118:1491-501. (PubMed:18340377)
  16. Migchielsen AA et al. (1996) Full genetic rescue of adenosine deaminase-deficient mice through introduction of the human gene. Hum Mol Genet, 5:1523-32. (PubMed:8894685)
  17. Migchielsen AA et al. (1995) Adenosine-deaminase-deficient mice die perinatally and exhibit liver-cell degeneration, atelectasis and small intestinal cell death. Nat Genet, 10:279-87. (PubMed:7670465)
  18. Mohsenin A et al. (2007) Genetic removal of the A2A adenosine receptor enhances pulmonary inflammation, mucin production, and angiogenesis in adenosine deaminase-deficient mice. Am J Physiol Lung Cell Mol Physiol, 293:L753-61. (PubMed:17601796)
  19. Sideraki V et al. (1996) Probing the functional role of two conserved active site aspartates in mouse adenosine deaminase. Biochemistry, 35:7862-72. (PubMed:8672487)
  20. Sun CX et al. (2005) A protective role for the A1 adenosine receptor in adenosine-dependent pulmonary injury. J Clin Invest, 115:35-43. (PubMed:15630442)
  21. Sun CX et al. (2006) Role of A2B adenosine receptor signaling in adenosine-dependent pulmonary inflammation and injury. J Clin Invest, 116:2173-2182. (PubMed:16841096)
  22. Thompson LF et al. (2000) Metabolites from apoptotic thymocytes inhibit thymopoiesis in adenosine deaminase-deficient fetal thymic organ cultures. J Clin Invest, 106:1149-57. (PubMed:11067867)
  23. Van De Wiele CJ et al. (2002) Adenosine kinase inhibition promotes survival of fetal adenosine deaminase-deficient thymocytes by blocking dATP accumulation. J Clin Invest, 110:395-402. (PubMed:12163459)
  24. Van De Wiele CJ et al. (2006) Further differentiation of murine double-positive thymocytes is inhibited in adenosine deaminase-deficient murine fetal thymic organ culture. J Immunol, 176:5925-33. (PubMed:16670300)
  25. Wakamiya M et al. (1995) Disruption of the adenosine deaminase gene causes hepatocellular impairment and perinatal lethality in mice. Proc Natl Acad Sci U S A, 92:3673-7. (PubMed:7731963)
  26. Werling U et al. (2002) Transcription factor gene AP-2 gamma essential for early murine development. Mol Cell Biol, 22:3149-56. (PubMed:11940672)
  27. Willems L et al. (2006) Effects of adenosine deaminase and A1 receptor deficiency in normoxic and ischaemic mouse hearts. Cardiovasc Res, 71:79-87. (PubMed:16626672)
  28. Winston JH et al. (1992) 5' flanking sequences of the murine adenosine deaminase gene direct expression of a reporter gene to specific prenatal and postnatal tissues in transgenic mice. J Biol Chem, 267:13472-9. (PubMed:1618849)
  29. Xu PA et al. (2000) Function of murine adenosine deaminase in the gastrointestinal tract. Biochem Biophys Res Commun, 269:749-57. (PubMed:10720488)
  30. Yasue M et al. (1991) Chromosomal assignments of 23 biochemical loci of the rat by using rat x mouse somatic cell hybrids. Cytogenet Cell Genet, 57:142-8. (PubMed:1914521)
  31. Young HW et al. (2004) A3 adenosine receptor signaling contributes to airway inflammation and mucus production in adenosine deaminase-deficient mice. J Immunol, 173:1380-9. (PubMed:15240734)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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