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Gene Ontology Classifications
activin receptor IIB

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GO curators for mouse genes have assigned the following annotations to the gene product of Acvr2b. (This text reflects annotations as of Tuesday, May 26, 2015.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of April 16, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Andersson O et al. (2006) Growth differentiation factor 11 signals through the transforming growth factor-beta receptor ALK5 to regionalize the anterior-posterior axis. EMBO Rep, 7:831-7. (PubMed:16845371)
  2. Andersson O et al. (2007) Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development. Dev Biol, 311:500-11. (PubMed:17936261)
  3. Attisano L et al. (1992) Novel activin receptors: distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors. Cell, 68:97-108. (PubMed:1310075)
  4. Dudas M et al. (2006) Epithelial and ectomesenchymal role of the type I TGF-beta receptor ALK5 during facial morphogenesis and palatal fusion. Dev Biol, 296:298-314. (PubMed:16806156)
  5. Ferguson CA et al. (2001) The role of effectors of the activin signalling pathway, activin receptors IIA and IIB, and Smad2, in patterning of tooth development. Development, 128:4605-13. (PubMed:11714685)
  6. Goto Y et al. (2007) Genetic interactions between activin type IIB receptor and Smad2 genes in asymmetrical patterning of the thoracic organs and the development of pancreas islets. Dev Dyn, 236:2865-74. (PubMed:17849440)
  7. Greenwald J et al. (2004) A flexible activin explains the membrane-dependent cooperative assembly of TGF-beta family receptors. Mol Cell, 15:485-9. (PubMed:15304227)
  8. Kim SK et al. (2000) Activin receptor patterning of foregut organogenesis. Genes Dev, 14:1866-71. (PubMed:10921901)
  9. Lee SJ et al. (2005) Regulation of muscle growth by multiple ligands signaling through activin type II receptors. Proc Natl Acad Sci U S A, 102:18117-22. (PubMed:16330774)
  10. Lee SJ et al. (2001) Regulation of myostatin activity and muscle growth. Proc Natl Acad Sci U S A, 98:9306-11. (PubMed:11459935)
  11. Lee YJ et al. (2006) Generation of activin receptor type IIB isoform-specific hypomorphic alleles. Genesis, 44:487-94. (PubMed:16991118)
  12. Matsuzaki T et al. (2002) Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway. J Biol Chem, 277:19008-18. (PubMed:11882656)
  13. Nakamura T et al. (1992) Isolation and characterization of activin receptor from mouse embryonal carcinoma cells. Identification of its serine/threonine/tyrosine protein kinase activity. J Biol Chem, 267:18924-8. (PubMed:1326537)
  14. Niessen K et al. (2010) ALK1 signaling regulates early postnatal lymphatic vessel development. Blood, 115:1654-61. (PubMed:19903896)
  15. Oh SP et al. (1997) The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse. Genes Dev, 11:1812-26. (PubMed:9242489)
  16. Oh SP et al. (2002) Activin type IIA and IIB receptors mediate Gdf11 signaling in axial vertebral patterning. Genes Dev, 16:2749-54. (PubMed:12414726)
  17. Park S et al. (2004) B-cell translocation gene 2 (Btg2) regulates vertebral patterning by modulating bone morphogenetic protein/smad signaling. Mol Cell Biol, 24:10256-62. (PubMed:15542835)
  18. Song J et al. (1999) The type II activin receptors are essential for egg cylinder growth, gastrulation, and rostral head development in mice. Dev Biol, 213:157-69. (PubMed:10452853)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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