Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Chrnd. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

This gene encodes the delta subunit of the muscle-derived nicotinic acetylcholine receptor, a pentameric neurotransmitter receptor and member of the ligand-gated ion channel superfamily. The delta subunit together with the alpha subunit forms the ligand-binding site. [provided by RefSeq, Nov 2012]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Chrnd
  • is located in the following cellular components:
    • acetylcholine-gated channel complex ^[2]
    • plasma membrane ^[3]
• The gene product of Chrnd has been shown to bind to the gene products of Canx, Chrnb1, Chrng. ^[2] Researchers have inferred, based on physical interactions, that the gene product of Chrnd
  • performs the following molecular functions:
  • is located in the following cellular components:
    • acetylcholine-gated channel complex ^[4]
• Researchers have inferred, based on genetic interactions, that the gene product of Chrnd
  • participates in the following biological processes:
    • cation transport based on interactions with Chrnb1, Chrng ^[2]
    • ion transmembrane transport based on interactions with Chrnb1, Chrng ^[2]
    • regulation of membrane potential based on interactions with Chrna1, Chrnb1, Chrne, Chrng ^{[1, 2]}
  • performs the following molecular functions:
    • acetylcholine binding based on interactions with Chrna1 ^[4]
    • acetylcholine-activated cation-selective channel activity based on interactions with Chrna1, Chrnb1, Chrne, Chrng ^{[1, 2]}

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Chrnd:
  • participates in the following biological processes:
    • musculoskeletal movement
    • skeletal muscle tissue growth
  • performs the following molecular functions:
    • acetylcholine-activated cation-selective channel activity
    • ligand-gated ion channel activity

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Summary text based on GO annotations supported by structural data

• Chrnd encodes a protein or proteins that contain the following InterPro domains: Neurotransmitter-gated ion-channel, Neurotransmitter-gated ion-channel ligand-binding, Neurotransmitter-gated ion-channel transmembrane domain, Neurotransmitter-gated ion-channel, conserved site, Nicotinic acetylcholine receptor, indicating that the gene product:
  • participates in the following biological processes:
    • ion transport
    • transport
  • performs the following molecular functions:
    • extracellular ligand-gated ion channel activity
    • ion channel activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane
    • postsynaptic membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Chrnd indicates that it:
  • participates in the following biological processes:
    • ion transport
    • transport
  • performs the following molecular functions:
    • ion channel activity
  • is located in the following cellular components:
    • cell junction
    • integral to membrane
    • membrane
    • postsynaptic membrane
    • synapse

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References

1. Gu Y et al. (1990) Properties of embryonic and adult muscle acetylcholine receptors transiently expressed in COS cells. Neuron, 5:147-57. (PubMed:2383398)
2. Keller SH et al. (1996) Involvement of the chaperone protein calnexin and the acetylcholine receptor beta-subunit in the assembly and cell surface expression of the receptor. J Biol Chem, 271:22871-7. (PubMed:8798466)
3. Marchand S et al. (2002) Rapsyn escorts the nicotinic acetylcholine receptor along the exocytic pathway via association with lipid rafts. J Neurosci, 22:8891-901. (PubMed:12388596)
4. Wang ZZ et al. (1996) Assembly of the nicotinic acetylcholine receptor. The first transmembrane domains of truncated alpha and delta subunits are required for heterodimer formation in vivo. J Biol Chem, 271:27575-84. (PubMed:8910344)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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