Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ace. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq, May 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Ace
  • participates in the following biological processes:
    • hormone catabolic process ^[3]
    • regulation of blood pressure ^[3]
  • performs the following molecular functions:
    • metallopeptidase activity ^[3]
    • peptidyl-dipeptidase activity ^[3]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Ace
  • participates in the following biological processes:
    • heart contraction ^[2]
    • kidney development ^[4]
    • metabolic process ^[5]
    • neutrophil mediated immunity ^[1]
    • positive regulation of systemic arterial blood pressure ^{[4, 5]}
    • spermatogenesis ^[4]
  • performs the following molecular functions:
    • peptidase activity ^[5]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Ace:
  • participates in the following biological processes:
    • angiogenesis involved in coronary vascular morphogenesis
    • arachidonic acid secretion
    • eating behavior
    • hormone catabolic process
    • kidney development
    • lung alveolus development
    • organ regeneration
    • peptide catabolic process
    • peptide metabolic process
    • positive regulation of apoptotic process
    • positive regulation of inflammatory response
    • positive regulation of neurogenesis
    • proteolysis
    • regulation of blood pressure
    • regulation of smooth muscle cell migration
    • response to lipopolysaccharide
    • sensory perception of pain
    • vasoconstriction
  • performs the following molecular functions:
    • actin binding
    • bradykinin receptor binding
    • chloride ion binding
    • drug binding
    • endopeptidase activity
    • metallopeptidase activity
    • peptide binding
    • peptidyl-dipeptidase activity
    • zinc ion binding
  • is located in the following cellular components:
    • endosome
    • external side of plasma membrane
    • extracellular space
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Ace encodes a protein or proteins that contain the following InterPro domains: Peptidase M2, peptidyl-dipeptidase A, indicating that the gene product:
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ace indicates that it:
  • participates in the following biological processes:
    • metabolic process
  • performs the following molecular functions:
    • carboxypeptidase activity
    • hydrolase activity
    • metal ion binding
  • is located in the following cellular components:
    • extracellular region
    • integral to membrane
    • membrane

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References

1. Arndt PG et al. (2006) Systemic inhibition of the angiotensin-converting enzyme limits lipopolysaccharide-induced lung neutrophil recruitment through both bradykinin and angiotensin II-regulated pathways. J Immunol, 177:7233-41. (PubMed:17082641)
2. Itoh S et al. (2006) Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium. Circulation, 113:1787-98. (PubMed:16585392)
3. Junot C et al. (2001) RXP 407, a selective inhibitor of the N-domain of angiotensin I-converting enzyme, blocks in vivo the degradation of hemoregulatory peptide acetyl-Ser-Asp-Lys-Pro with no effect on angiotensin I hydrolysis. J Pharmacol Exp Ther, 297:606-11. (PubMed:11303049)
4. Kessler SP et al. (2007) Vascular expression of germinal ACE fails to maintain normal blood pressure in ACE-/- mice. FASEB J, 21:156-66. (PubMed:17135368)
5. Tian B et al. (1997) Blood pressures and cardiovascular homeostasis in mice having reduced or absent angiotensin-converting enzyme gene function. Hypertension, 30:128-33. (PubMed:9231832)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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