Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Acads. (This text reflects annotations as of Wednesday, January 23, 2013.)

---

Summary from NCBI RefSeq

This gene encodes a homotetrameric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the Acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum at C(four)-CoA. In mice, deficiency of this gene has been linked to cold sensitivity and increased high-density lipoprotein levels. [provided by RefSeq, Nov 2012]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Acads
  • is located in the following cellular components:
    • mitochondrion ^{[1, 2]}

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Acads:
  • participates in the following biological processes:
    • butyrate catabolic process
    • fatty acid beta-oxidation using acyl-CoA dehydrogenase
    • protein homotetramerization
  • performs the following molecular functions:
    • acyl-CoA dehydrogenase activity
    • butyryl-CoA dehydrogenase activity
    • fatty-acyl-CoA binding
    • flavin adenine dinucleotide binding
  • is located in the following cellular components:
    • mitochondrial matrix
    • mitochondrial membrane
    • mitochondrion

---

Summary text based on GO annotations supported by structural data

• Acads encodes a protein or proteins that contain the following InterPro domains: Acyl-CoA dehydrogenase, conserved site, Acyl-CoA dehydrogenase, N-terminal, Acyl-CoA dehydrogenase/oxidase, Acyl-CoA dehydrogenase/oxidase C-terminal, Acyl-CoA dehydrogenase/oxidase, N-terminal, Acyl-CoA oxidase/dehydrogenase, central domain, Acyl-CoA oxidase/dehydrogenase, type 1, indicating that the gene product:
  • participates in the following biological processes:
    • metabolic process
    • oxidation-reduction process
  • performs the following molecular functions:
    • oxidoreductase activity, acting on the CH-CH group of donors

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Acads indicates that it:
  • participates in the following biological processes:
    • fatty acid metabolic process
    • lipid metabolic process
    • oxidation-reduction process
  • performs the following molecular functions:
    • oxidoreductase activity

---

References

1. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell, 115:629-40. (PubMed:14651853)
2. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---