Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Acadm. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

This gene encodes a homotetrameric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum length between C6- and C12-acylCoA. In mice, deficiency of this gene can cause neonatal mortality as well as fasting and cold intolerance. This gene has multiple, intronless pseudogenes. [provided by RefSeq, Nov 2012]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Acadm
  • is located in the following cellular components:
    • mitochondrion ^{[2, 3]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Acadm
  • participates in the following biological processes:
    • cardiac muscle cell differentiation ^[4]
    • carnitine metabolic process ^[4]
    • carnitine metabolic process, CoA-linked ^[1]
    • fatty acid beta-oxidation using acyl-CoA dehydrogenase ^[1]
    • glycogen biosynthetic process ^[1]
    • heart development ^[4]
    • liver development ^[4]
    • medium-chain fatty acid metabolic process ^[1]
    • organic acid metabolic process ^[4]
    • post-embryonic development ^[4]
    • regulation of gluconeogenesis ^[1]
    • response to cold ^[4]
    • response to starvation ^[4]
  • performs the following molecular functions:
    • medium-chain-acyl-CoA dehydrogenase activity ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Acadm:
  • participates in the following biological processes:
    • carnitine biosynthetic process
    • carnitine metabolic process, CoA-linked
    • fatty acid beta-oxidation
    • fatty acid beta-oxidation using acyl-CoA dehydrogenase
    • medium-chain fatty acid catabolic process
    • medium-chain fatty acid metabolic process
    • oxidation-reduction process
    • protein homotetramerization
  • performs the following molecular functions:
    • acyl-CoA dehydrogenase activity
    • fatty-acyl-CoA binding
    • flavin adenine dinucleotide binding
    • identical protein binding
    • isomerase activity
    • medium-chain-acyl-CoA dehydrogenase activity
  • is located in the following cellular components:
    • axon
    • mitochondrial matrix
    • mitochondrial membrane
    • mitochondrion

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Summary text based on GO annotations supported by structural data

• Acadm encodes a protein or proteins that contain the following InterPro domains: Acyl-CoA dehydrogenase, conserved site, Acyl-CoA dehydrogenase, N-terminal, Acyl-CoA dehydrogenase/oxidase, Acyl-CoA dehydrogenase/oxidase C-terminal, Acyl-CoA dehydrogenase/oxidase, N-terminal, Acyl-CoA oxidase/dehydrogenase, central domain, Acyl-CoA oxidase/dehydrogenase, type 1, indicating that the gene product:
  • participates in the following biological processes:
    • metabolic process
    • oxidation-reduction process
  • performs the following molecular functions:
    • oxidoreductase activity, acting on the CH-CH group of donors

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Acadm indicates that it:
  • participates in the following biological processes:
    • fatty acid metabolic process
    • lipid metabolic process
    • oxidation-reduction process
  • performs the following molecular functions:
    • oxidoreductase activity
• Acadm has been associated with the Enzyme Commission numbers: 1.3.8.7, which implies that the gene product:
  • participates in the following biological processes:
    • oxidation-reduction process

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References

1. Herrema H et al. (2008) Disturbed hepatic carbohydrate management during high metabolic demand in medium-chain acyl-CoA dehydrogenase (MCAD)-deficient mice. Hepatology, 47:1894-904. (PubMed:18459129)
2. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell, 115:629-40. (PubMed:14651853)
3. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)
4. Tolwani RJ et al. (2005) Medium-chain acyl-CoA dehydrogenase deficiency in gene-targeted mice. PLoS Genet, 1:e23. (PubMed:16121256)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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